CORE--Shared Resources Chemical Library

核心--共享资源化学库

• 批准号: 7231446
• 负责人: Jeffrey W Smith
• 金额: $ 14.29万
• 依托单位: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7231446
• 关键词: biomedical facility; chemical registry /resource; combinatorial chemistry; neoplastic process; small molecule

DESCRIPTION (provided by applicant): The long-term objective of the Cancer Center's Chemical Library Screening Facility is to provide new chemical tools for elucidating the basic mechanisms that underlie tumor onset and progression, and to provide lead chemical compounds for initiation of the development of anti-tumor drugs. Small molecule agonists and antagonists have proven to be invaluable tools for solving problems in biology. Since high-throughput screening is not widely available at academic institutions, this facility will provide a new and unique approach toward understanding and combating cancer. The Cancer Center's Chemical Library Screening Facility was founded in mid-2002. The facility was built with funds provided by the Institute and from the fund-raising efforts of Principle Investigators. At the present time the Facility is not funded by the CCSG. The rapid success of the Facility, and the anticipated heavy demand for its services provide the rationale for the funding that is requested. The Specific Aims of the Chemical Library Screening Facility are to: 1) Establish and maintain a large chemical library, and an accompanying database, for screening against molecular targets in cancer; 2) Provide consultation to the Faculty of the Cancer Center in the design of high-throughput assays; 3) Provide high throughput screening services to the Faculty of the Cancer Center; and 4) Provide virtual screening capabilities to the Faculty of the Cancer Center.

描述（由申请人提供）：癌症中心化学的长期目标 图书馆筛查设施是为阐明肿瘤发作和进展的基本机制提供新的化学工具，并提供铅化合物以启动抗肿瘤药物的发展。事实证明，小分子激动剂和拮抗剂是解决生物学问题的宝贵工具。由于高通量筛查在学术机构不广泛使用，因此该设施将为理解和打击癌症提供一种新的独特方法。癌症中心的化学图书馆筛查设施成立于2002年中。该设施是由研究所提供的资金以及主要调查人员的筹款工作。目前，该设施尚未由CCSG资助。该设施的快速成功以及预期的对服务的大量需求为要求的资金提供了理由。化学文库筛选设施的具体目的是：1）建立和维护一个大型化学文库以及随附的数据库，以筛选癌症中的分子靶标； 2）在高通量测定法设计时向癌症中心教师提供咨询； 3） 向癌症中心的教职员工提供高通量筛查服务； 4）为癌症中心的学院提供虚拟筛查功能。