400 MHz Nuclear Magnetic Resonance Spectrometer

400 MHz 核磁共振波谱仪

• 批准号: 7795621
• 负责人: DAVID G VANDERVELDE
• 金额: $ 31.54万
• 依托单位: CALIFORNIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-11-26 至 2010-11-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7795621
• 关键词: California; Chemical Engineering; Chemistry; Core Facility; Faculty; Funding; Institutes; Methodology; Nuclear Magnetic Resonance; Research; Research Personnel; Technology; United States National Institutes of Health; instrument; member; professor

DESCRIPTION (provided by applicant): In this proposal, a group of six faculty members in the Division of Chemistry and Chemical Engineering at the California Institute of Technology are requesting a shared 400 MHz nuclear magnetic resonance spectrometer. All are synthetic organic chemists; all but one (a recently hired assistant professor) have NIH funding. Three of the investigators (Grubbs, Reisman, Stoltz) have a strong focus on methodology; the others (Dervan, Dougherty, Hsieh-Wilson) have a more bio-organic focus. The requested instrument is intended to be a faster, more capable, and modern replacement for an antiquated 300 MHz instrument used for immediate characterization of newly synthesized compounds. It would be placed in a core facility where more than 50,000 spectra are acquired annually, but four of the seven instruments are 300 MHz spectrometers poorly matched to the needs of modern research at Caltech, and two of the three higher field instruments are quite old. The requested instrument would be a key component of a revitalized core facility at Caltech.

描述（由申请人提供）：在此提案中，加利福尼亚理工学院化学和化学工程科的六个教职员工要求共享400 MHz的核磁共振光谱仪。所有都是合成有机化学家；除了一位（最近雇用的助理教授）外，所有人都有NIH资金。三名研究人员（Grubbs，Reisman，Stoltz）非常关注方法论。其他（Dervan，Dougherty，Hsieh-Wilson）具有更大的生物有机焦点。该请求的仪器旨在用于更快，更有能力和现代的替代品，用于用于立即表征新合成化合物的过时的300 MHz仪器。它将被放置在每年获取50,000多个光谱的核心设施中，但是七种仪器中有四种是300 MHz光谱仪，与加州理工学院现代研究的需求匹配不佳，而三种高级仪器中的两种则相当古老。请求的仪器将是加州理工学院振兴核心设施的关键组成部分。

项目成果

Direct, Enantioselective Synthesis of Pyrroloindolines and Indolines From Simple Indole Derivatives.

• DOI: 10.1016/j.tet.2013.04.003
• 发表时间: 2013-07-08
• 期刊: Tetrahedron
• 影响因子: 2.1
• 作者: Ni J;Wang H;Reisman SE
• 通讯作者: Reisman SE

Trinuclear Nickel Complexes with Metal-Arene Interactions Supported by Tris- and Bis(phosphinoaryl)benzene Frameworks.

• DOI: 10.1021/om400976x
• 发表时间: 2013-12-09
• 期刊: Organometallics
• 影响因子: 2.8
• 作者: Suseno S;Horak KT;Day MW;Agapie T
• 通讯作者: Agapie T

Enantioselective total synthesis of (-)-acetylaranotin, a dihydrooxepine epidithiodiketopiperazine.

• DOI: 10.1021/ja209354e
• 发表时间: 2012-02-01
• 期刊: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
• 影响因子: 15
• 作者: Codelli, Julian A.;Puchlopek, Angela L. A.;Reisman, Sarah E.
• 通讯作者: Reisman, Sarah E.

Synthesis of Enantioenriched Indolines by a Conjugate Addition/Asymmetric Protonation/Aza-Prins Cascade Reaction.

• DOI: 10.1002/anie.201510972
• 发表时间: 2016-03-01
• 期刊: Angewandte Chemie (International ed. in English)
• 作者: Daniels BE;Ni J;Reisman SE
• 通讯作者: Reisman SE

Dinickel Bisphenoxyiminato Complexes for the Polymerization of Ethylene and α-Olefins.

• DOI: 10.1021/om2011694
• 发表时间: 2012-03-26
• 期刊: Organometallics
• 影响因子: 2.8
• 作者: Radlauer M;Day MW;Agapie T
• 通讯作者: Agapie T