Imaging Core

成像核心

• 批准号: 7499278
• 负责人: Robert H Brown
• 金额: $ 36.06万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-14 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7499278
• 关键词: Area; Canis familiaris; Chronic Obstructive Airway Disease; Databases; Development; Economic Inflation; Generations; Helium; Human; Image; Link; Lung; Magnetic Resonance Imaging; Measurement; Measures; Publications; Publishing; Pulmonary Emphysema; Range; Research Personnel; Resolution; Sheep; Structure of parenchyma of lung; Techniques; Thick; Work; airway remodeling; density; in vivo; indexing; lung imaging; lung volume; pulmonary function; response; size; tool

CORES: The imaging acquisition and analysis core was established in response to the growing need of several investigators for High-resolution CT image acquisition and analysis across a range of species. Since our publication of the first use of HRCT to assess airway reactivity in dogs, we have published several subsequent studies, using HRCT to measure airway walls and airway size changes in dogs, in sheep, and in humans. Due to developing needs, we have hired Dr. Masaru Ishii to expanding the imaging acquisition and analysis core unit to include Magnetic Resonance imaging, specifically hyperpolarized helium (3He) imaging acquisition and analysis. The strength of the imaging core has been demonstrated by our ability to acquire highly reproducible lung images for quantitative analysis of airways and parenchyma. Conventional pulmonary function measurements are unable to assess airway stiffness or reduced maximum airway size, as measured by changes in airway size with lung inflation. HRCT is a direct, noninvasive, radiological technique that can accurately and reliably measure airway luminal area and airway wall thickness in human airways in vivo. Using HRCT, one can make repeated airway luminal and airway wall thickness measurements of multiple airways at different lung volumes in vivo. In the proposed work, we will use HRCT to make repeated measures of airway size at various lung volumes, airway wall thickness in multiple airways (2nd to 8th generation airways), and lung parenchyma! density in subjects with COPD as an index of airway remodeling. Furthermore, the development of a consistent database of airway images will be instrumental in linking projects related to progression of COPD. HRCT also has been demonstrated to be a precise tool for the quantification of emphysema by measurement of lung parenchyma! density. In order to increase the sensitivity of this measurement of treatment and harmful exposures, we plan to evaluate regions of lung with low destructive index as a measure of COPD progression. The Core will support Projects 2 and 5 and will interact with Core C.

核心： 图像采集和分析核心的建立是为了满足一些日益增长的需求 研究人员对一系列物种进行高分辨率 CT 图像采集和分析。自从我们的 首次使用 HRCT 评估狗的气道反应性，我们已经发表了几篇 随后的研究，使用 HRCT 测量狗、羊和动物的气道壁和气道尺寸变化 人类。由于发展需要，我们聘请Masaru Ishii博士来扩大图像采集和 分析核心单元包括磁共振成像，特别是超极化氦 (3He) 成像 采集和分析。成像核心的实力已经通过我们获取数据的能力得到了证明 高度可重复的肺部图像，用于气道和实质的定量分析。传统的 肺功能测量无法评估气道硬度或最大气道尺寸的减小， 通过气道大小随肺膨胀的变化来测量。 HRCT 是一种直接、无创、放射学检查 能够准确可靠地测量人体气道管腔面积和气道壁厚度的技术 体内气道。使用HRCT，可以重复测量气道管腔和气道壁厚度 体内不同肺容量的多个气道的测量。在拟议的工作中，我们将使用 HRCT 重复测量不同肺容量的气道尺寸、多个气道的气道壁厚度 （第二代至第八代气道）和肺实质！作为气道指标的 COPD 受试者的密度 重塑。此外，开发一致的气道图像数据库将有助于 将与慢性阻塞性肺病进展相关的项目联系起来。 HRCT 也已被证明是一种精确的工具 通过测量肺实质来量化肺气肿！密度。为了增加 由于这种治疗和有害暴露测量的敏感性，我们计划用以下方法评估肺部区域： 低破坏指数作为 COPD 进展的衡量标准。核心将支持项目 2 和 5，并将 与 Core C 交互。