Micro Coherence Imaging Technology for Assessing Obstructive Lung Disease in vivo

用于评估体内阻塞性肺病的微相干成像技术

• 批准号: 8756282
• 负责人: Robert H Brown
• 金额: $ 68.15万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8756282
• 关键词: Acute; Address; Adopted; Affect; Air; American; Asthma; Biomedical Engineering; Biomedical Research; Blood Vessels; Bronchiectasis; Caliber; Canis familiaris; Cartilage; Chronic Obstructive Airway Disease; Clinical; Development; Diagnosis; Diagnostic; Disease; Disease Progression; Endoscopes; Engineering; Etiology; Evaluation; Future; Gland; Health Care Costs; Histology; Human; Image; Imaging technology; Indium; Individual; Ionizing radiation; Lamina Propria; Lead; Lung; Lung diseases; Measurement; Modeling; Muscle Contraction; Obstructive Lung Diseases; Operating System; Optical Coherence Tomography; Optics; Outcome; Pathogenesis; Pathologic; Pathology; Patients; Penetration; Performance; Peripheral; Physiological; Physiology; Play; Pulmonary Edema; Pulmonology; Research; Resolution; Respiratory physiology; Role; Scanning; Severities; Severity of illness; Simulate; Site; Speed; Structure; System; Technology; Terminal Bronchiole; Therapeutic; Thick; Time; Tissues; Treatment outcome; Work; X-Ray Computed Tomography; base; constriction; design; direct application; imaging modality; imaging probe; improved; in vivo; in vivo Model; innovation; innovative technologies; insight; lung volume; novel; programs; public health relevance; respiratory smooth muscle; response; treatment effect; treatment response

DESCRIPTION (provided by applicant): This Biomedical Research Partnership (BRP) proposal involves a partnership among a biomedical engineering team, a pulmonary physiology team, and a clinical pulmonary medicine team. This research program will incorporate state of the art optical engineering, advanced in vivo physiologic evaluation, and direct application to human obstructive lung diseases (OLD). Optical coherence tomography (OCT) is a technology capable of real time imaging of tissue microstructures in vivo, at micron scale resolution, and without ionizing radiation. Due to existing methodological limitations, this technology has not been utilized in any diagnostic or therapeutic venue related to OLD. To overcome these limitations, our partnership will develop and optimize a miniature OCT imaging probe and OCT imaging system. We hypothesize that high-resolution, high-speed, endoscopic OCT systems will allow identification and quantification of critical changes in tissue components in the airway wall that lead to OLD, and we will demonstrate the feasibility and evaluate the resolution of this endoscopic OCT platform in vivo in a canine model. We also hypothesize that this innovative technology can be applied to human lung disease to elucidate the etiology, progression of disease, and response to therapy in humans with OLD. We will demonstrate the efficacy of OCT in subjects with COPD and asthma. This innovative BRP proposal involves a working partnership involving state of the art optical engineering, advanced in vivo physiologic evaluation, and direct application to human lung disease. The biomedical engineering team will design and fabricate an ultrathin high-resolution OCT scanning endoscope systems at two wavelengths with an optimal working distance for accurately assessing thickness and fine structures of the airway walls in the peripheral small airways in vivo. The pulmonary physiology team will determine the accuracy of OCT resolution in vivo in small size canine airways. Finally, the clinical pulmonary medicine team will determine the correlations between the structural elements in the airway wall and the severity of OLD in humans. These works determines the mechanisms of OLD and enable future evaluations of new and existing therapeutic treatments by noninvasively quantifying their effects on airway wall structures and lung function.

描述（由申请人提供）：该生物医学研究合作伙伴关系 (BRP) 提案涉及生物医学工程团队、肺生理学团队和临床肺医学团队之间的合作关系。该研究计划将结合最先进的光学工程、先进的体内生理评估以及对人类阻塞性肺疾病（OLD）的直接应用。光学相干断层扫描（OCT）是一种能够以微米级分辨率对体内组织微观结构进行实时成像且无需电离辐射的技术。由于现有方法学的限制，该技术尚未应用于任何与 OLD 相关的诊断或治疗场所。为了克服这些限制，我们的合作伙伴将开发和优化微型 OCT 成像探头和 OCT 成像系统。我们假设高分辨率、高速、内窥镜 OCT 系统将能够识别和量化气道壁组织成分的关键变化 导致 OLD，我们将在犬模型体内展示该内窥镜 OCT 平台的可行性并评估其分辨率。我们还假设这种创新技术可以应用于人类肺部疾病，以阐明老年肺病的病因、疾病进展以及对治疗的反应。我们将证明 OCT 对慢性阻塞性肺病和哮喘患者的疗效。这项创新的 BRP 提案涉及一种工作伙伴关系，涉及最先进的光学工程、先进的体内生理评估以及对人类肺部疾病的直接应用。生物医学工程团队将设计并制造两个波长、最佳工作距离的超薄高分辨率OCT扫描内窥镜系统，以准确评估体内周围小气道的气道壁厚度和精细结构。肺生理学团队将确定小尺寸犬气道体内 OCT 分辨率的准确性。最后，临床肺医学团队将确定气道壁的结构元素与人类 OLD 严重程度之间的相关性。这些工作确定了 OLD 的机制，并通过非侵入性量化新的和现有的治疗方法对气道壁结构和肺功能的影响来评估新的和现有的治疗方法。