PULMONARY AIRWAY AND VASCULAR FUNCTION ASSESSED BY HRCT
HRCT 评估肺气道和血管功能
基本信息
- 批准号:2210581
- 负责人:
- 金额:$ 8.61万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1992
- 资助国家:美国
- 起止时间:1992-09-30 至 1997-09-29
- 项目状态:已结题
- 来源:
- 关键词:bronchoconstrictors bronchodilators computed axial tomography computer simulation dogs hypercapnia hypervolemia hypovolemia mass spectrometry mathematical model pulmonary edema pulmonary veins respiratory airway volume respiratory disorder diagnosis respiratory function respiratory hypoxia respiratory pharmacology respiratory system statistics /biometry
项目摘要
The goal of this Clinical Investigator Development Award is to further
development and training of an independent academic investigator in
anesthesiology and physiology.
The research will emphasize a new technology that permits
three-dimensional reconstruction of the pulmonary airways and vessels in
vivo. It has two primary objectives, the first to establish the local
responsiveness of conducting airways to various stimuli, the second to
determine the extent of interaction between the pulmonary vasculature and
conducting airways. Specific research aims will first be directed toward
the testing of the response of airways to a variety of interventions
relevant to standard airways function tests used to assess lung disease.
We will test the mechanism and extent of regional airway response
heterogeneity in different size airways in vivo to bronchoconstrictors
and bronchodilators that have been reported to differentially constrict
portions the airway tree or work through different pharmacologic
pathways. I will also be able to evaluate the effect of the pulmonary
vasculature on the airway tree. Preliminary data have shown that even
relatively large conducting airways can be partially obstructed when the
pulmonary vasculature pressure is increased. We hypothesize that this
interaction between the vasculature and airway tree will affect the
responses of the airways to endogenous and exogenous stimulation. To
test this hypothesis we will quantify airway and regional vascular
distensibility and their interaction using computerized reconstruction of
the in vivo airway and vascular trees. We will also determine the
progressive effects of increasing pulmonary edema on in situ airway size
and regional vascular dimensions. The airway and vascular morphometric
data will be applied to existing analytical models of the airway and
vascular tree. I will also test the extent of regional airway response
heterogeneity through the airway tree to physiologic stimuli known to
worsen pulmonary status in clinical conditions, specifically,
hypervolemia, hypovolemia, hypercapnia, and hypoxia. The results from
all of these investigations will have a significant impact on our
understanding and interpretation of pulmonary function in the clinical
setting.
该临床研究者发展奖的目标是进一步
开发和培训独立学术研究员
麻醉和生理学。
该研究将强调一种允许的新技术
肺气道和血管中的三维重建
体内。 它有两个主要目标,第一个建立本地的目标
向各种刺激进行气道的响应能力,第二
确定肺脉管系统与
进行气道。 具体的研究目标将首先针对
气道对各种干预措施的响应测试
与用于评估肺部疾病的标准气道功能测试有关。
我们将测试区域气道响应的机制和程度
在体内到支气管收集器的不同大小气道的异质性
以及已报告的支气管扩张剂
部分气道树或通过不同的药理学工作
途径。 我还将能够评估肺的影响
气道树上的脉管系统。 初步数据表明,即使
当相对较大的导电道可能会被部分阻塞
肺血管压力增加。 我们假设这是
脉管系统与气道树之间的相互作用将影响
气道对内源性和外源刺激的反应。 到
检验此假设,我们将量化气道和区域血管
使用计算机化的重构
体内气道和血管树。 我们还将确定
增加肺水肿对原位气道尺寸的渐进作用
和区域血管维度。 气道和血管形态计量学
数据将应用于气道的现有分析模型和
血管树。 我还将测试区域气道响应的程度
通过气道树到已知的生理刺激的异质性
在临床条件下,肺状况恶化,特别是
高毒素,低血容量,高碳酸血症和缺氧。 结果
所有这些调查将对我们的
临床中肺功能的理解和解释
环境。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Robert H Brown其他文献
Amyotrophic Lateral Sclerosis: Fuel for the Corticofugal Feud
肌萎缩侧索硬化症:皮质不和的燃料
- DOI:
- 发表时间:
2020 - 期刊:
- 影响因子:11.2
- 作者:
B. Wainger;Robert H Brown - 通讯作者:
Robert H Brown
Arterial delivery of myoblasts to skeletal muscle
成肌细胞经动脉输送至骨骼肌
- DOI:
10.1212/wnl.42.12.2258 - 发表时间:
1992 - 期刊:
- 影响因子:9.9
- 作者:
A. Neumeyer;D. Digregorio;Robert H Brown - 通讯作者:
Robert H Brown
Superoxide dismutase and familial amyotrophic lateral sclerosis: New insights into mechanisms and treatments
超氧化物歧化酶与家族性肌萎缩侧索硬化症:机制和治疗的新见解
- DOI:
10.1002/ana.410390202 - 发表时间:
1996 - 期刊:
- 影响因子:11.2
- 作者:
Robert H Brown - 通讯作者:
Robert H Brown
A Handoffs Software Led to Fewer Errors of Omission and Better Provider Satisfaction: A Randomized Control Trial
交接软件可以减少遗漏错误并提高提供商满意度:随机对照试验
- DOI:
- 发表时间:
2017 - 期刊:
- 影响因子:2.2
- 作者:
M. Kashiouris;C. Stefanou;Deepankar Sharma;Cecilia Yshii;R. Vega;Sarah Hartigan;Charles R. Albrecht;Robert H Brown - 通讯作者:
Robert H Brown
Quantifying and Mitigating Motor Phenotypes Induced by Quantifying and Mitigating Motor Phenotypes Induced by Antisense Oligonucleotides in the Central Nervous System Antisense Oligonucleotides in the Central Nervous System
量化和减轻中枢神经系统中反义寡核苷酸诱导的运动表型 量化和减轻中枢神经系统中反义寡核苷酸诱导的运动表型
- DOI:
- 发表时间:
2022 - 期刊:
- 影响因子:0
- 作者:
Michael P. Moazami;Julia M. Rembetsy;Feng Wang;P. M. Krishnamurthy;Alexandra Weiss;M. Marosfoi;Robert M. King;M. Motwani;H. Gray;Katherine A. Fitzgerald;Robert H Brown;Jonathan K. Watts - 通讯作者:
Jonathan K. Watts
Robert H Brown的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Robert H Brown', 18)}}的其他基金
Micro Coherence Imaging Technology for Assessing Obstructive Lung Disease in vivo
用于评估体内阻塞性肺病的微相干成像技术
- 批准号:
8756282 - 财政年份:2014
- 资助金额:
$ 8.61万 - 项目类别:
Micro Coherence Imaging Technology for Assessing Obstructive Lung Disease in vivo
用于评估体内阻塞性肺病的微相干成像技术
- 批准号:
9276757 - 财政年份:2014
- 资助金额:
$ 8.61万 - 项目类别:
Mechanisms of Reduced Airway Distension in Severe Asthma
减少严重哮喘气道扩张的机制
- 批准号:
7392279 - 财政年份:2007
- 资助金额:
$ 8.61万 - 项目类别:
Mechanisms of Reduced Airway Distension in Severe Asthma
减少严重哮喘气道扩张的机制
- 批准号:
7312428 - 财政年份:2006
- 资助金额:
$ 8.61万 - 项目类别:
Mechanisms of Reduced Airway Distension in Severe Asthma
减少严重哮喘气道扩张的机制
- 批准号:
6967832 - 财政年份:2004
- 资助金额:
$ 8.61万 - 项目类别:
STRUCTURAL MECHANISMS OPERATING IN UNRESPONSIVE ASTHMA
无反应性哮喘的结构机制
- 批准号:
6638541 - 财政年份:2000
- 资助金额:
$ 8.61万 - 项目类别:
STRUCTURAL MECHANISMS OPERATING IN UNRESPONSIVE ASTHMA
无反应性哮喘的结构机制
- 批准号:
6129448 - 财政年份:2000
- 资助金额:
$ 8.61万 - 项目类别:
STRUCTURAL MECHANISMS OPERATING IN UNRESPONSIVE ASTHMA
无反应性哮喘的结构机制
- 批准号:
6390376 - 财政年份:2000
- 资助金额:
$ 8.61万 - 项目类别:
STRUCTURAL MECHANISMS OPERATING IN UNRESPONSIVE ASTHMA
无反应性哮喘的结构机制
- 批准号:
6537599 - 财政年份:2000
- 资助金额:
$ 8.61万 - 项目类别:
相似海外基金
PULMONARY AIRWAY AND VASCULAR FUNCTION ASSESSED BY HRCT
HRCT 评估肺气道和血管功能
- 批准号:
3083220 - 财政年份:1992
- 资助金额:
$ 8.61万 - 项目类别: