PULMONARY AIRWAY AND VASCULAR FUNCTION ASSESSED BY HRCT

HRCT 评估肺气道和血管功能

• 批准号: 3083220
• 负责人: Robert H Brown
• 金额: $ 8.48万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至 1997-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3083220
• 关键词: bronchoconstrictors; bronchodilators; computed axial tomography; computer simulation; dogs; hypercapnia; hypervolemia; hypovolemia; mass spectrometry; mathematical model; pulmonary edema; pulmonary veins; respiratory airway volume; respiratory disorder diagnosis; respiratory function; respiratory hypoxia; respiratory pharmacology; respiratory system; statistics /biometry

The goal of this Clinical Investigator Development Award is to further development and training of an independent academic investigator in anesthesiology and physiology. The research will emphasize a new technology that permits three-dimensional reconstruction of the pulmonary airways and vessels in vivo. It has two primary objectives, the first to establish the local responsiveness of conducting airways to various stimuli, the second to determine the extent of interaction between the pulmonary vasculature and conducting airways. Specific research aims will first be directed toward the testing of the response of airways to a variety of interventions relevant to standard airways function tests used to assess lung disease. We will test the mechanism and extent of regional airway response heterogeneity in different size airways in vivo to bronchoconstrictors and bronchodilators that have been reported to differentially constrict portions the airway tree or work through different pharmacologic pathways. I will also be able to evaluate the effect of the pulmonary vasculature on the airway tree. Preliminary data have shown that even relatively large conducting airways can be partially obstructed when the pulmonary vasculature pressure is increased. We hypothesize that this interaction between the vasculature and airway tree will affect the responses of the airways to endogenous and exogenous stimulation. To test this hypothesis we will quantify airway and regional vascular distensibility and their interaction using computerized reconstruction of the in vivo airway and vascular trees. We will also determine the progressive effects of increasing pulmonary edema on in situ airway size and regional vascular dimensions. The airway and vascular morphometric data will be applied to existing analytical models of the airway and vascular tree. I will also test the extent of regional airway response heterogeneity through the airway tree to physiologic stimuli known to worsen pulmonary status in clinical conditions, specifically, hypervolemia, hypovolemia, hypercapnia, and hypoxia. The results from all of these investigations will have a significant impact on our understanding and interpretation of pulmonary function in the clinical setting.

该临床研究者发展奖的目标是进一步 独立学术研究者的发展和培训 麻醉学和生理学。 该研究将强调一项新技术，该技术允许 肺气道和血管的三维重建 体内。 它有两个主要目标，第一个目标是建立地方 引导气道对各种刺激的反应性，其次是 确定肺血管系统和肺血管系统之间相互作用的程度 传导气道。 具体研究目标首先针对 测试气道对各种干预措施的反应 与用于评估肺部疾病的标准气道功能测试相关。 我们将测试区域气道反应的机制和程度 体内不同大小气道对支气管收缩剂的异质性 和据报道具有不同收缩作用的支气管扩张剂 分割气道树或通过不同的药理作用 途径。 我还能够评估肺部的效果 气道树上的脉管系统。 初步数据显示，即使 当相对较大的传导气道可能被部分阻塞时 肺血管压力升高。 我们假设这 脉管系统和气道树之间的相互作用会影响 气道对内源性和外源性刺激的反应。 到 为了检验这个假设，我们将量化气道和局部血管 使用计算机重建的可扩展性及其相互作用 体内气道和血管树。 我们还将确定 肺水肿增加对原位气道尺寸的渐进影响 和区域血管尺寸。 气道和血管形态测量 数据将应用于现有的气道分析模型 维管树。 我还将测试区域气道反应的程度 通过气道树到已知的生理刺激的异质性 临床状况下肺部状况恶化，具体来说， 高血容量、低血容量、高碳酸血症和缺氧。 结果来自 所有这些调查都将对我们产生重大影响 临床上对肺功能的理解和解释 环境。