Image-Guided Photodynamic Therapy of Lung Cancer

影像引导肺癌光动力治疗

基本信息

批准号：
8902062
负责人：
CHUKWUMERE E. NWOGU
金额：
$ 22.9万
依托单位：
ROSWELL PARK CANCER INSTITUTE CORP
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-08-01 至 2017-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8902062
关键词：
4T1 Abbreviations Accounting Adjuvant Adjuvant Chemotherapy Animal Model Animals Area Award Breast Cancer Model Cancer Etiology Cancer Model Canis familiaris Cessation of life Chlorophyll Chronic Obstructive Airway Disease Clinic Clinical Clinical Trials Colon Comorbidity Detection Development Diagnosis Diagnostic Neoplasm Staging Disease Distant Drainage procedure Excision FDA approved Family suidae Fluorescence Funding Goals Health Human Image Invaded Ipsilateral Label Laboratories Lesion Light Local Therapy Lung Lung Neoplasms Malignant Neoplasms Malignant neoplasm of lung Microscopic Modality Modeling Morbidity - disease rate Neoplasm Metastasis Nodal Non-Small-Cell Lung Carcinoma Operative Surgical Procedures Outcome PUVA Photochemotherapy Patients Phase Photosensitizing Agents Porfimer Sodium Positron-Emission Tomography Primary Neoplasm Radiation therapy Radioactive Radioisotopes Radiosurgery Recurrence Research Resectable Resected Residual Tumors Respiratory physiology SCID Mice Skin Structure Structure of lymph node of thorax Structure of parenchyma of lung Surgical margins Therapeutic Tobacco use Toxic effect Translating Treatment Efficacy Tumor stage United States Woman Xenograft procedure absorption analog base bone chemotherapy compare effectiveness disorder control effective therapy falls fluorescence imaging fluorodeoxyglucose image guided imaging agent improved lymph nodes meetings men novel novel therapeutics operation pre-clinical tumor

项目摘要

DESCRIPTION (provided by applicant): This Exploratory/Developmental Research Award will provide the funds for Drs. Nwogu and Pandey to study a novel "Multifunctional Agent" for image guided (PET/fluorescence) surgery and photodynamic therapy (PDT) in preclinical animal models. Translating this to the clinic will markedly change the treatment paradigm for locoregional non-small cell lung cancer and result in improved outcomes for patients. Detection of occult lymph node disease will be enhanced and intraoperative adjuvant photodynamic therapy can be accomplished. Additionally, patients whose comorbidities preclude surgical resection can have a repeatable, effective therapy (PDT). In order to achieve our imaging and therapeutic goals, this study is divided into following aims: 1) Compare the effectiveness of 124I-PS2 and 18F-Fluorodeoxyglucose (FDG) in imaging of lung tumors and lymph node metastases using an orthotopic lung cancer model in SCID mice. 2) Compare the effectiveness of photodynamic therapy using PS2 and Porfimer Sodium (Photofrin(R)) in human NSCLC xenografts established subcutaneously in SCID mice. On completion of the proposed project, we plan to study the therapeutic efficacy of this novel multifunctional radioisotope in a larger animal orthotopic lung cancer model such as dogs or pigs. PDT to both the lung tumor and its nodal drainage basin will be better refined in such larger animal models. This will be followed by phase I human clinical trials. The target subset of patients to whom this would be applicable include those with resectable primary NSCLC who are undergoing surgery to resect lesions that are larger than 3 cm or invading surrounding structures, or any patients with clinical ipsilateral thoracic lymph node disease. A local therapy to the regional lymph node basin and surgical margins that can be delivered with minimal morbidity immediately following resection of a primary tumor and its draining lymph nodes could dramatically reduce disease recurrence and improve long term survival. This is a novel therapeutic paradigm.

描述（由申请人提供）：该探索性/发展性研究奖将为博士提供资金。 Nwogu 和 Pandey 研究一种新型“多功能制剂”，用于临床前动物模型中的图像引导（PET/荧光）手术和光动力治疗（PDT）。将其转化为临床将显着改变局部非小细胞肺癌的治疗模式，并改善患者的预后。将加强对隐匿性淋巴结疾病的检测，并可以完成术中辅助光动力治疗。此外，患有合并症而无法进行手术切除的患者可以获得可重复的有效治疗（PDT）。为了实现我们的成像和治疗目标，本研究分为以下目标： 1) 使用原位肺癌模型比较 124I-PS2 和 18F-氟脱氧葡萄糖 (FDG) 在肺肿瘤和淋巴结转移成像中的有效性SCID小鼠。 2) 比较使用 PS2 和 Porfimer Sodium (Photofrin(R)) 进行光动力治疗在 SCID 小鼠皮下建立的人类 NSCLC 异种移植物中的有效性。拟议项目完成后，我们计划研究这种新型多功能放射性同位素在较大动物原位肺癌模型（如狗或猪）中的治疗效果。在此类较大的动物模型中，对肺肿瘤及其淋巴结引流盆的 PDT 将得到更好的改进。随后将进行一期人体临床试验。适用的目标患者亚组包括那些患有可切除的原发性 NSCLC 且正在接受手术切除大于 3 cm 或侵入周围结构的病灶的患者，或任何患有临床同侧胸部淋巴结疾病的患者。在切除原发性肿瘤及其引流淋巴结后立即对区域淋巴结盆地和手术边缘进行局部治疗，可显着减少疾病复发并提高长期生存率。这是一种新颖的治疗范例。