Metabolism Core

新陈代谢核心

基本信息

批准号：
7333100
负责人：
DAVID B ALLISON
金额：
$ 13.62万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-01 至 2012-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7333100
关键词：
Acquired Immunodeficiency Syndrome Aging Alabama Animals Area Arthritis Award Back Baptist Church Biology Biomedical Research Biometry Body Composition Budgets Burn Centers Cardiovascular system Cities Class Clinical Clinical Nutrition Clinical Research Collaborations Community Health Community Outreach Complement Comprehensive Cancer Center Contracts Cystic Fibrosis Dentistry Development Diabetes Mellitus Direct Costs Discipline Discipline of Nursing Disease Education Elderly Energy Metabolism Enrollment Environment Epidemiology Extramural Activities Faculty Food Interactions Fostering Free Radicals Funding Genes Genetic Grant Growth Health Health Maintenance Organizations Health Occupations Health Professional Health Promotion Health Resources Health Services Research Healthcare Industry Hospitals Immunity Immunobiology Industry Infection Institution Interdisciplinary Study Investigation Laboratories Laboratory Personnel Leadership Measures Medical center Medicine Metabolism Methodist Church Micronutrients Mission National Center for Research Resources National Institute of Diabetes and Digestive and Kidney Diseases Neurobiology Nurses Nutrient Nutritional Study Obesity Optometry Organ Transplantation Oxidative Stress Pediatric Hospitals Phenotype Process Productivity Public Health Public Health Education Recording of previous events Recovery Recruitment Activity Reporting Research Research Infrastructure Research Personnel Research Project Grants Research Training Resource Development Resources Schools Scientist Series Services Sexually Transmitted Diseases Sickle Cell Social Medicine Students System Technology Title Training Training Programs United States National Institutes of Health Universities Vaccines Veterans Work base cancer prevention college cost falls gene interaction instrumentation interest international center member multidisciplinary nutrition post-doctoral training pre-doctoral programs success symposium trend

项目摘要

We request renewed funding to continue the documented success achieved in the first cycle of UAB's Clinical Nutrition Research Unit (CNRU). Inaugurated through NIH funding in 2000 and supported by UAB's formal system of University-wide Interdisciplinary Research Centers, our CNRU fosters multidisciplinary, collaborative approaches to basic clinical and translational nutrition research, with emphasis on obesity. In 1996, UAB established an intramurally-funded University-Wide Obesity-Nutrition Research Center which, with NIH funding, evolved into the present CNRU. Since first funded by NIDDK, our research base has grown from $44M (88% federal; 11 R01s) to $72M (92% federal; 40 R01s) in annual direct funding for nutrition/obesity studies¿an overall increase of 61% in research funding. UAB's CNRU has directly helped recruit at least 16 new and established obesity and nutrition investigators in the past funding cycle. Currently, our CNRU leadership oversees an NIDDK-funded T32 post-doctoral training grant for obesity research, a newly awarded industry sponsored pre-doctoral obesity training grant, an NIH-funded R25 Cancer Prevention and Control Training Program emphasizing nutrition, an endowed professorship and endowed chair in nutrition sciences, an NIH-funded U54 Center for Nutrient-Gene Interaction, and an annual series of NIH-funded nutrition and obesity-related short courses and conferences. Our CNRU funds at least four P/F studies per year, a New Investigator, and an extensive Enrichment Program. UAB has granted the CNRU over $1.6M since its inception as an NIH-funded CNRU, developing CNRU Cores in Energy Metabolism/Body Composition, Genetics, Small Animal Phenotyping and Biostatistics, for shared instrumentation, operating expenses and recruitment, resulting in cost-effective research and enhanced access to cutting-edge technology. Approximately 85% of the funded nutrition/obesity studies in our research base use CNRU Cores. Our secondary foci or points of converging research interests including gene-nutrient interaction, dietary effects on oxidative stress, and health effects of phytonutrients and micronutrients are nurtured in synergistic collaboration with other centers on campus including our NCI-funded Comprehensive Cancer Center and our Center for Free-Radical Biology. Backed by exceptional institutional support and academic infrastructure, we request renewed funding to continue our successful nutrition/obesity research.

我们要求更新的资金继续在UAB的第一个周期中取得的有记录的成功临床营养研究部门（CNRU）。 2000年通过NIH资金开幕，并得到UAB的支持大学范围跨学科研究中心的形式系统，我们的CNRU养育了多学科的培训，基本临床和翻译营养研究的协作方法，重点是肥胖。在 1996年，UAB建立了一个由校内资助的大学范围内的肥胖症研究中心，该研究中心，该中心，有了NIH资金，演变为当前的CNRU。自Niddk首次资助以来，我们的研究基础已经从4,400万美元（88％的联邦； 11 R01）到7200万美元（92％的联邦； 40 R01）的年度直接资金营养/肥胖研究的研究资金总体上增加了61％。 UAB的CNRU直接帮助了在过去的融资周期中，至少招募了至少16名新的肥胖和营养研究者。现在，我们的CNRU领导层监督了NIDDK资助的T32肥胖研究博士后培训补助金新授予的行业赞助的博士前肥胖培训补助金是NIH资助的R25癌症预防和控制培训计划强调营养，赋予教授职位并赋予营养科学主席，NIH资助的U54营养互动中心和一系列年度系列 NIH资助的营养和与肥胖有关的短期课程和会议。我们的CNRU资金至少四个P/F 每年研究，新的研究者和广泛的丰富计划。 UAB已授予CNRU 自从其成立为NIH资助的CNRU以来，超过160万美元，开发了CNRU核心代谢/身体组成，遗传学，小动物表型和生物统计学，用于共享仪器，运营费用和招聘，导致成本效益的研究并增强访问尖端技术。我们研究中约有85％的资助营养/肥胖研究基本使用CNRU内核。我们的次要焦点或包括基因营养素在内的研究兴趣点相互作用，对氧化应激的饮食影响以及植物营养素和微量营养素的健康影响是与校园其他中心协同合作进行了协同合作，包括我们的NCI资助的综合癌症中心和我们的自由基生物学中心。得到卓越的机构支持和学术基础设施，我们要求续签资金，以继续我们成功的营养/肥胖研究。