A Dynamic COVID-19 Community-Engaged Testing Strategy in Alabama (COVID COMET AL)

阿拉巴马州动态的 COVID-19 社区参与测试策略 (COVID COMET AL)

• 批准号: 10355693
• 负责人: Renee A. Heffron
• 金额: $ 156.2万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-23 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10355693
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Aging; Alabama; Area; Award; Basic Science; Behavioral; Behavioral Sciences; Biology; Budgets; COVID-19; Caring; Clinical; Clinical Data; Clinical Research; Collaborations; Communication; Communities; Computerized Medical Record; Core Facility; Culture Techniques; Database Management Systems; Development; Discipline; Disease; Educational workshop; Effectiveness; Evolution; Extramural Activities; Faculty; Faculty Recruitment; Flow Cytometry; Fostering; Funding; Grant; HIV; Human immunodeficiency virus test; Institutes; Interdisciplinary Study; International; Intervention; Intervention Studies; Investments; Leadership; Link; Location; Mentors; Methodology; Methods; Mission; Molecular Virology; NIH Grants and Contracts; Outcomes Research; Outsourcing; Pathogenesis; Peer Review; Prevention; Prevention Research; Process; Productivity; Program Development; Publications; Research; Research Activity; Research Design; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Risk Assessment; Services; Southeastern United States; Specimen; Spirituality; Statistical Data Interpretation; Strategic Planning; Testing; Therapeutic; Tissue Procurements; Tissue Transplantation; Training; Training Support; Translational Research; Treatment Efficacy; Underrepresented Minority; United States; United States National Institutes of Health; Woman; base; community based participatory research; community engaged research; community science; coronavirus disease; epidemiology study; innovation; interest; member; minority children; minority investigator; novel; operation; population health; programs; recruit; service utilization; social stigma; transmission process; treatment research; vaccine development; virus culture; working group

PROJECT SUMMARY Overall The mission of the UAB CFAR is to support the conduct of cutting-edge research in basic science, therapeutics, prevention, community engaged research, and clinical manifestations and pathogenesis of HIV and related disorders. Five core facilities provide vital support for the Center's principal thematic areas of its scientific agenda. To optimize our CFAR operation, an intensive strategic planning process has established efficiencies through streamlining its cores from 7 to 5, taking full advantage of existing services provided by other centers on campus, outsourcing under-utilized services, and allowing for investments in new areas (Specific Aims workshops, Transplant Tissue Procurement Facility, and Ending HIV in Alabama SWG). The Center includes 185 members from over 30 divisions and departments within UAB. Over the last 4 years, the UAB CFAR has enabled research leading to FRB / total funding of $21M / $66M. The majority (62%) was newly obtained in this budget period; 57% of these are related to basic science, 18% to population health prevention and treatment research, 22% to behavioral epi and intervention research, and 3% to community engaged research. Since our last renewal, the center has increased the number of young investigators supported by training awards from 7 to 16 (14 women; 5 under-represented minorities, URMs) and invested $1.9M in new-investigator pilot awards yielding $25M in outside funding. Overall, for our ROI in pilot funding is 13:1 in new extramural grants awarded. The Center helped recruit 45 new HIV/AIDS investigators in the last 4 years (17 external, 28 new to HIV research), of whom 21 are women and 5 URMs. Across all cores the CFAR supported 61 unique, NIH-funded projects (FRB) and 404 other NIH-funded projects, of which 309 were HIV-specific resulting in over 1000 HIV publications, and in the garnering of strong Institutional support. Over the next 5 years we will: (1) Continue to enhance the productivity of ongoing research programs by enabling interdisciplinary research through the provision of critical shared resource facilities and administrative and fiscal management support to Center investigators (2) Use robust strategic planning methods to identify new research opportunities and priorities that align with existing CFAR programs and foster new research programs where none are in existence, but where faculty interest is evident; (3) Stimulate the entry of early stage and established faculty into HIV/AIDS research programs through mentoring programs for young investigators and through a robust, peer-reviewed Developmental Grants Program; (4) Provide a central focus for HIV/AIDS research activities at UAB that emphasize effective communication and collaboration among CFAR members with the wider HIV/AIDS research community; and (5) Promote faculty recruitment and program development in areas that reflect the ongoing evolution of HIV/AIDS research in Alabama, the United States, and around the world. The UAB CFAR will foster HIV/AIDS research that has high local, national, and international impact and in so doing will promote the NIH priorities of innovation and effectiveness in AIDS treatment and prevention.

项目概要 全面的 UAB CFAR 的使命是支持基础科学、治疗学、 HIV 及相关疾病的预防、社区参与研究以及临床表现和发病机制 失调。五个核心设施为其科学议程的主要专题领域提供重要支持。 为了优化我们的 CFAR 运营，密集的战略规划流程通过以下方式提高了效率： 将其核心从 7 个精简为 5 个，充分利用校园内其他中心提供的现有服务， 外包未充分利用的服务，并允许在新领域进行投资（具体目标研讨会、 移植组织采购设施，以及阿拉巴马州 SWG 终结艾滋病毒）。中心现有会员185人 来自 UAB 内 30 多个部门和部门。在过去 4 年里，UAB CFAR 推动了研究 导致 FRB / 总资金达到 2100 万美元 / 6600 万美元。大部分（62%）是在本预算期内新获得的； 其中57%与基础科学相关，18%与人口健康防治研究相关，22%与 行为外延和干预研究，3% 用于社区参与研究。自从我们上次更新以来， 中心将接受培训奖资助的年轻调查员人数从 7 名增加到 16 名（14 名女性； 5 个代表性不足的少数族裔 (URM) 并投资 190 万美元用于新研究者试点奖励，产生了 2500 万美元 外部资金。总体而言，我们的试点资金投资回报率为 13:1 的新校外拨款。中心帮助了 过去 4 年招募 45 名新的艾滋病毒/艾滋病调查员（17 名外部人员，28 名艾滋病毒研究新人），其中 21 名是 女性和 5 个 URM。在所有核心中，CFAR 支持 61 个独特的 NIH 资助项目 (FRB) 和 404 个其他项目 NIH 资助的项目，其中 309 个是针对艾滋病毒的，产生了 1000 多份艾滋病毒出版物，并且正在收集 强有力的制度支持。未来5年我们将： (1) 通过跨学科研究继续提高正在进行的研究项目的生产力 通过提供关键的共享资源设施以及行政和财政管理支持 中心研究人员 (2) 使用稳健的战略规划方法来识别新的研究机会和 与现有 CFAR 计划相一致的优先事项，并在不存在的情况下促进新的研究计划， 但教师的兴趣显而易见； (3) 促进早期和已建立的教师队伍进入艾滋病毒/艾滋病领域 通过针对年轻研究人员的指导计划以及通过强有力的同行评审的研究计划 发展补助金计划； (4) 为 UAB 的艾滋病毒/艾滋病研究活动提供一个中心重点， 强调 CFAR 成员与更广泛的艾滋病毒/艾滋病研究之间的有效沟通与合作 社区; (5) 促进反映当前领域的教师招聘和项目开发 阿拉巴马州、美国和世界各地艾滋病毒/艾滋病研究的进展。 UAB CFAR 将促进具有高度地方、国家和国际影响力的艾滋病毒/艾滋病研究，并因此 此举将促进 NIH 在艾滋病治疗和预防方面的创新和有效性优先事项。