Mentoring and research to prepare oral PrEP delivery platforms for novel HIVprevention products

指导和研究，为新型 HIV 预防产品准备口服 PrEP 递送平台

基本信息

批准号：
10642471
负责人：
Renee A. Heffron
金额：
$ 12.71万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-01 至 2025-12-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10642471
关键词：
AIDS prevention Adherence Africa African African American population Award Behavioral Sciences Clinical Clinical Research Cognitive Communicable Diseases Communities Counseling Dapivirine Doctor of Philosophy Dose Epidemiologist Epidemiology Evaluation Faculty Female Funding Grant HIV HIV Infections HIV risk Home Hour Incidence Injectable International Interview Kenya Lesotho Manuscripts Mentors Methods Modality Oral Persons Phase III Clinical Trials Postdoctoral Fellow Preparation Prevention Research Provider Qualitative Research Reproductive Health Research Research Assistant Research Personnel Safety Science Scientist South Africa Structure Tenofovir Time Training Translational Research Uganda Underrepresented Populations United States National Institutes of Health Universities Vaginal Ring Vision Washington Woman Work base career design doctoral student experience experimental study global health implementation research implementation science informant meetings mid-career faculty next generation novel patient oriented research phase III trial pill pre-doctoral pre-exposure prophylaxis preference programs side effect skills social theories uptake young woman

项目摘要

ABSTRACT This is a career mentoring award to support Dr. Renee Heffron, Associate Professor at the University of Washington, with protected time to create a more structured approach to mentoring for herself and her colleagues and to increase the number of mentees that she has by at least 50%. Mentees will be among the next generation of researchers focused on HIV prevention, oral pre-exposure prophylaxis (PrEP), and novel PrEP products. Dr. Heffron, PhD, MPH is a clinical epidemiologist with advanced training in implementation science, behavioral science, and qualitative research. Dr. Heffron's mentoring style is grounded in the Social Cognitive Career Theory and includes emphasis on developing mentee's science identify. Mentees will work alongside Dr. Heffron on the newly proposed research in the K24 in the realm of implementation science as well as on her four ongoing NIH-funded studies in Uganda, Kenya, and South Africa. Mentoring aims are to: 1. Support and grow the next generation of US- and Africa-based leaders conducting patient-oriented research focused on delivery of oral PrEP and novel PrEP products through the provision of structured mentoring to a total of 20-40 (~5 new mentees/year) pre-doctoral students, postdoctoral fellows, junior faculty, and other junior investigators, including subsets who are female and identify as being from URG. 2. Establish and refine a structured mentoring program within the International Clinical Research Center, my research home within the University of Washington Department of Global Health. Newly proposed research provides opportunity for Dr. Heffron to grow her repertoire of work in implementation science, in order to identify best practices to integrate novel PrEP products into existing platforms for oral PrEP delivery by conducting 60 key informant qualitative interviews with experts developing novel PrEP products, PrEP program implementers, and end users who discontinued or rejected use of oral PrEP. A discrete choice experiment will be conducted with young women in Uganda to identify their preferences for different attributes of HIV prevention counseling and whether counseling scenarios would facilitate uptake of a PrEP product. Research specific aims are to: 1. Define a preliminary strategy for the integration of novel PrEP products (e.g., injectable Cabotegravir, Dapivirine intravaginal ring, TFV/LNG intravaginal ring) into existing oral PrEP programs by conducting qualitative interviews with experts in novel PrEP products, oral PrEP programs, and end users 2. Among young women who have discontinued or never initiated oral PrEP, to determine preferences for attributes of HIV prevention counseling that would support them to initiate and sustain use of a PrEP product

抽象的这是一项职业指导奖，旨在支持大学副教授Renee Heffron博士华盛顿，有了受保护的时间，为自己和她创造更结构化的指导方法同事，并增加了至少50％的受训者人数。受训将是下一代研究人员专注于预防艾滋病毒，口服预防预防（PREP）和新颖准备产品。 Heffron博士博士，MPH是一名临床流行病学家，接受了实施的高级培训科学，行为科学和定性研究。 Heffron博士的指导风格基于社会认知职业理论，包括强调发展受训者的科学认同。受训者将工作与Heffron博士一起，在实施科学领域的K24新提出的研究中就像她在乌干达，肯尼亚和南非正在进行的四项NIH资助的研究一样。指导目的是： 1。支持和发展下一代美国和非洲的领导者进行以患者为导向的研究专注于通过提供结构化指导的口服准备和新型准备产品共有20-40（〜5名新的受训者/年）博士学前学生，博士后研究员，初级教师和其他初级调查人员，包括女性的子集，并确定为来自URG。 2。在国际临床研究中心建立并完善结构化指导计划，我华盛顿大学全球卫生系的研究家。新提出的研究为Heffron博士提供了发展其实施工作曲目的机会科学，为了确定最佳实践，将新颖的准备产品整合到现有的口头准备平台中通过对开发新型准备产品的专家进行60次关键线人定性访谈，交付准备程序实施者以及中断或拒绝使用口服准备的最终用户。一个离散的选择实验将与乌干达的年轻妇女进行，以确定她们对不同属性的偏好艾滋病毒预防咨询以及咨询场景是否有助于吸收准备产品。研究特定目的是： 1。定义新型准备产品整合的初步策略（例如，可注射的Cabotegravir， dapivirine静脉内环，TFV/LNG静脉内环）通过进行现有口服准备程序与新型预备产品，口头准备计划和最终用户的专家的定性访谈 2。在停止或从未开始口服准备的年轻妇女中，以确定对艾滋病毒预防咨询的属性将支持他们启动和维持使用准备产品