Nutrition, Biostatistics and Bioinformatics

营养学、生物统计学和生物信息学

基本信息

批准号：
7460525
负责人：
Raymond J. Carroll
金额：
$ 52.43万
依托单位：
TEXAS A&M UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-07-01 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7460525
关键词：
Affect American Animals Apoptosis Applications Grants Area Assimilations Biochemical Biochemistry Bioinformatics Biological Biology Biometry Biostatistical Methods Cancer Etiology Cancer and Nutrition Cell Cycle Cell physiology Cellular Structures Cellular biology Chemicals Chemistry Chronic Disease Class Classification Clinical Nutrition Complex Computational Biology Computer software Consult Core Facility Critiques Data Data Analyses Depth Development Diet Digestion Disease Doctor of Philosophy Down-Regulation Educational Curriculum Educational process of instructing Electrical Engineering Elements Emerging Technologies Engineering Environment Enzymes Ethical Issues Ethics Evaluation Evolution Experimental Designs Faculty Food Food Additives Funding GNAS gene Gene Expression Gene Expression Regulation Genes Genetic Genetic screening method Genomics Goals Grant Guidelines Head Heredity Home environment Human Image Immunity Individual Institutes Instruction Interview Joints Journals Knowledge Label Laboratories Lead Learning Life Literature Malignant Neoplasms Medicine Mentors Metabolism Methodology Methods Microarray Analysis Minerals Modeling Molecular Molecular Biology Molecular Toxicology Network-based Neurosciences Nucleotides Nutrient Nutrition aspect of cancer Nutritional Nutritional Biochemistry Nutritional Study Nutritionist Oligonucleotides Operative Surgical Procedures Oral Paper Phase Physiological Polymerase Chain Reaction Population Genetics Postdoctoral Fellow Preparation Prevention Principal Investigator Process Proteomics Publishing Purpose Quantitative Genetics Reading Recommendation Regulation Regulator Genes Reporting Reproductive Technology Research Research Methodology Research Personnel Research Project Grants Research Proposals Resolution Resources Risk Assessment Role Rotation Running Rural Health Sample Size Schedule Science Scientific Misconduct Scientist Series Signal Transduction Societies Specialist Statistical Data Interpretation Statistical Methods Structure Students Surveys System Techniques Technology Texas Thinking Time Toxicogenetics Toxicology Toxin Training Training Programs Treatment Protocols United States National Institutes of Health Universities Vertebrates Veterinary Medicine Vocabulary Water-Soluble Vitamin Week Work Writing absorption anticancer research base bioimaging carcinogenesis college computer science computerized data processing concept data mining day design desire diet and cancer expectation experience experimental analysis falls instructor interest lectures lipid metabolism member microbial multidisciplinary neurotoxicology nutrient metabolism nutrition post-doctoral training pre-doctoral programs reproductive research study skills statistics symposium vitamin metabolism

项目摘要

DESCRIPTION (provided by applicant): The goal of this continuation proposal is to train statistically oriented individuals (Biostatisticians, Statisticians, Electrical Engineers, etc.) to function as independent researchers in a multidisciplinary environment focusing on Nutrition and cancer. To achieve this goal we have assembled a team of researchers specializing in Biostatistics, Bioinformatics, Genomic Signal Processing and the biology of Nutrition and cancer. Our basic premise is that multidisciplinary teams working on Nutrition and cancer will benefit enormously by inclusion of biologically knowledgeable biostatisticians, and especially biostatisticians who are familiar at a fairly deep level with the biological mechanisms of cancer of most interest to nutritionists. This basic premise is supplemented by our observation that there exist few biostatisticians of the desired type. We will continue to create a cadre of statistically oriented researchers who understand the mechanisms of action in the relationship between Nutrition and cancer. Such understanding will allow our trainees to contribute at the highest level to the design and analysis of experiments in the area, and to develop fine-tuned statistical methods truly appropriate for the experimental data. Through a combination of didactic coursework, seminars and research experiences, we expect our trainees to be able to make important contributions in the development of statistical methods targeted to experiments in nutrition and cancer, and to function as a true collaborator in teams of biologists, instead of merely as a specialist in setting sample sizes and performing data analysis of simple experiments. The program plan is designed to (a) provide via courses and seminars systematic training in biology as it relates to nutrition and cancer; (b) provide intensive laboratory experience, with a rotation through a genomics facility, initial laboratory rotations followed by long-term work with one of the Human Nutrition laboratories, including attending weekly laboratory meetings but more generally becoming a full member of the laboratory team; and (c) provide directed research experience with either a biostatistical or electrical engineering mentor in combination with nutritionist mentors from the Faculty of Nutrition.

描述（由申请人提供）：该延续提案的目标是培训统计学的个人（生物统计学家，统计学家，电气工程师等），以在关注营养和癌症的多学科环境中充当独立研究人员。为了实现这一目标，我们组建了一组研究人员，专门研究生物统计学，生物信息学，基因组信号处理以及营养和癌症的生物学。我们的基本前提是，从事营养和癌症的多学科团队将通过纳入生物学知识渊博的生物统计学家，尤其是生物统计学家，这些团队将在熟悉的生物学家熟悉的生物学机制中熟悉最重要的生物学机制，从而大大受益。我们的观察结果补充了这一基本前提。我们将继续创建一组面向统计学的研究人员，他们了解营养与癌症之间关系中的作用机理。这种理解将使我们的学员能够为该地区的实验设计和分析以最高级别的贡献，并开发出适合实验数据的微调统计方法。通过教学课程，研讨会和研究经验的结合，我们希望学员能够在开发针对营养和癌症实验的统计方法方面做出重要贡献，并在生物学家团队中充当真正的合作者，而不是仅仅是在设置样本大小和执行简单实验分析的专家方面的专家。该计划计划旨在（a）通过与营养和癌症有关的生物学的课程和研讨会系统培训；（b）提供密集的实验室经验，并通过基因组学设施进行轮换，最初的实验室轮换，然后与人类营养实验室之一进行长期工作，包括参加每周的每周实验室会议，但通常会成为实验室的正式成员；（c）与营养学院的营养学家指导者结合使用生物统计学或电气工程导师提供有导的研究经验。