Nutrition, Biostatistics and Bioinformatics

营养学、生物统计学和生物信息学

• 批准号: 8542494
• 负责人: Raymond J. Carroll
• 金额: $ 54万
• 依托单位: TEXAS A&M UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8542494
• 关键词: American; Area; Bioinformatics; Biology; Biometry; Cancer Etiology; Cancer Research Project; Cancer and Nutrition; Computers; Computing Methodologies; Consult; DNA Sequence; Data; Department of Defense; Diet; Doctor of Philosophy; Educational Curriculum; Electrical Engineering; Emerging Technologies; Engineering; Enrollment; Environment; Faculty; Foundations; Funding; Genomics; Goals; Individual; Institutes; Laboratories; Learning; Mentors; National Cancer Institute; Nature; Nutritionist; Phenotype; Postdoctoral Fellow; Principal Investigator; Proteomics; Qualifying; Regulator Genes; Research; Research Personnel; Rotation; Science; Scientist; Statistical Methods; Texas; Time; Training; Training Programs; Universities; anticancer research; base; cancer chemoprevention; cancer prevention; college; computer science; computerized data processing; design; experience; experimental analysis; graduate student; high throughput analysis; malignant breast neoplasm; meetings; member; multidisciplinary; nutrition; post-doctoral training; programs; research study; statistics

DESCRIPTION (provided by applicant): Our goal in this continuation proposal is to train statistically and computationally oriented individuals (Biostatisticians, Statisticians, Electrical Engineers, Computer Scientists, etc.) to function as independent researchers in a multidisciplinary environment focusing on cancer research, researchers who are trained in the fundamentals of Nutrition and Cancer. To achieve this goal we have assembled a team specializing in Biostatistics/Statistics, Bioinformatics, Computer Science, Genomic Signal Processing and the biology of Nutrition and Cancer. 1) The training is fully multidisciplinary. a) We focus on training statistically and computationally oriented individuals in the biology of Nutrition and Cancer, creating researchers who understand the underlying mechanisms of action in the relationship between Nutrition and Cancer. Such understanding will allow our trainees to contribute at the highest level to the design and analysis of experiments in the area, and to develop fine-tuned statistical methods truly appropriate for the experimental data. b) The training will include initial rotations through 3 laboratories, as well as a rotation with the Texas A&M Genomics Facility, the co-director of which is a diet chemoprevention cancer biologist in our training program, followed by intensive long-term training in a single laboratory. c) We now include formal training specific to our program that emphasizes Fundamental Principles of Nutrition and Emerging Technologies and their Applications. 2) Each trainee will have at least two mentors. a) A Nutritionist whose research focuses on cancer etiology and prevention. The trainee will be expected to become a full member of the nutritionist's laboratory, including spending significant time in the laboratory, attending laboratory meetings, consulting for the graduate students and postdoctoral researchers in the laboratory, supervising the analysis of experimental data and eventually posing new problems and approaches. b) A Biostatistician, an Electrical Engineer or a Computer Scientist. Our team includes experts in the analysis of experimental data arising from Nutrition and Cancer, particularly those of a longitudinal nature; the analysis of high throughput expression data, DNA sequencing and phenotype data; the analysis of proteomics data; the construction and the control of gene regulatory networks, etc.

描述（由申请人提供）：我们在该延续建议中的目标是在统计和以计算为导向的人（生物统计学家，统计学家，电气工程师，计算机科学家等）上培训，以在关注癌症研究的多学科研究中充当独立研究人员，在营养和癌症基础上接受了培训的研究人员。为了实现这一目标，我们组建了一个专门研究生物统计学/统计学，生物信息学，计算机科学，基因组信号处理以及营养和癌症生物学的团队。 1）培训是完全多学科的。 a）我们专注于营养和癌症生物学上的统计和计算方向的个体，创造了研究人员，这些研究人员了解营养与癌症之间关系中的基本作用机制。这种理解将使我们的学员能够为该地区的实验设计和分析以最高级别的贡献，并开发出适合实验数据的微调统计方法。 b）培训将包括通过3个实验室进行初始旋转，以及与德克萨斯A＆M基因组学设施的旋转，该设施的联合导演是我们的培训计划中的饮食化学预防癌生物学家，然后在单个实验室中进行了深入的长期培训。 c）现在，我们包括针对我们计划的正式培训，该培训强调了营养和新兴技术及其应用的基本原理。 2）每个学员至少有两名导师。 a）一位营养师的研究侧重于癌症的病因和预防。预计学员将成为营养学家实验室的正式成员，包括在实验室中度过大量时间，参加实验室会议，咨询研究生和实验室的博士后研究人员，监督对实验数据的分析并最终提出新问题和方法。 b）生物统计学家，电气工程师或计算机科学家。我们的团队包括对营养和癌症产生的实验数据的专家，尤其是纵向性质的专家；高吞吐量数据，DNA测序和表型数据的分析；蛋白质组学数据的分析；基因调节网络的构建和控制等。