CLINICAL CORE

临床核心

• 批准号: 7644964
• 负责人: Joseph J Eron
• 金额: $ 35.72万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7644964
• 关键词: AIDS prevention; AIDS/HIV problem; Access to Information; Acquired Immunodeficiency Syndrome; Acute; Affect; Anti-Retroviral Agents; Award; Behavioral; Biology of HIV Transmission; Cellular Immunology; Clinic; Clinical; Clinical Data; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Services; Clinical Trials; Collaborations; Communication; Communication Research; Communities; Complement; Computers; Consent; Data; Data Analyses; Data Linkages; Databases; Development; Elements; Epidemiologist; Evaluation; Evolution; Family health status; Feasibility Studies; Goals; Grant; HIV; HIV Infections; HIV vaccine; Hearing; Human Resources; Individual; Industry; Institutes; Institution; International; Investigation; K-Series Research Career Programs; Knowledge; Laboratories; Leadership; Link; Local Area Networks; Medical; Minority; Nature; Orphan Drugs; Participant; Patient Recruitments; Patients; Persons; Postdoctoral Fellow; Prema; Productivity; Recruitment Activity; Research; Research Design; Research Ethics Committees; Research Infrastructure; Research Personnel; Research Project Grants; Resistance; Resources; Retrieval; Sampling; Scientist; Services; Specialist; Specimen; Students; Surveys; Testing; Time; Time Study; Training; Translational Research; United States Food and Drug Administration; United States National Institutes of Health; Universities; Work; base; database design; design; experience; member; multidisciplinary; novel; outreach; programs; repository; skills; symposium; translational study; vaccine development

The primary goal of the UNC CFAR Clinical Core (Core C) is to facilitate and enhance clinical and translational HIV/AIDS research at UNC, Family Health International (FHI) and Research Triangle Institute (RTI). Core C accomplishes this goal by serving CFAR members who are established in HIV clinical and translational research and seeking out and assisting new investigators including experienced HIV basic scientists new to translational research, experienced clinical investigators new to HIV/AIDS and especially junior investigators establishing themselves in HIV research. Core C is composed of Dr. Joseph Eron (Director), Ms. Prema Menezes (Associate Core Director), Dr. Sonia Napravnik, (Epidemiologist), Dr. Christopher Pilcher (Core Investigator), Dr. Evelyn Quinlivan (Core Investigator), a part time study coordinator, two full time research assistants, one full-time clinic screener, a part time research assistant, and two part time programmers / computer specialists. Specific services offered include: assistance with design, development and conduct of clinical and translational studies including subject identification, recruitment and consent, project coordination, obtaining clinical samples, database design and management; NIH grant submission, IRB, GCRC and FDA investigational and orphan drug application support; access to the UNC CFAR HIV/AIDS Clinical Research Database (UNC CFAR-DB) and linked specimen repository including over 1700 consented participants to date; access to comprehensive data from the Clinical Socio-Demographic in-person survey including detailed behavioral information; access to the UNC Acute HIV Infection Clinical Research Program expertise and data; and access to HIV basic and clinical investigators on the three UNC CFAR campuses and from outside institutions. Core C has used these services to support a large variety of studies including HIV vaccine development (AI46023, AI50246), cellular immunology (AI20288, GM67143), the biology of HIV transmission (DK49381), acute HIV infection (MH68686), V3 (envelope) evolution (AI44667), HIV resistance (AI50845), HIV prevention (AI46749, MH69989), and antiretroviral and other HIV clinical trials (AI25868). Core C has provided leadership in HIV/AIDS Research communication by establishing a CFAR-wide local area network (LAN), the comprehensive UNC CFAR-DB and linked specimen repository, a monthly collaborative research meeting and a yearly AIDS symposium. Core C enhances training of medical and graduate students, post doctoral fellows and junior investigators as evidenced by support of student research projects, CFAR developmental awards and K-23 awards. Core C also helped establish productive collaborations with outside institutions and industry. Outreach efforts to international collaborators, and to HIV investigators, clinicians and HIV-infected individuals in the community are ongoing.

UNC CFAR临床核心（核心C）的主要目标是促进和增强临床和 UNC，Family Health International（FHI）和研究三角研究所的转化艾滋病毒/艾滋病研究 （RTI）。核心C通过为在HIV临床和 翻译研究并寻求和协助新的研究人员，包括经验丰富的HIV基本 转化研究的新手，经验丰富的临床研究者，艾滋病毒/艾滋病，尤其是 初级调查人员在艾滋病毒研究中建立自己。 Core C由Joseph Eron博士组成 （董事），Prema Menezes女士（副总监），Sonia Napravnik博士（流行病学家），博士 克里斯托弗·皮尔彻（Christopher Pilcher）（核心调查员），伊夫琳·昆利文（Evelyn Quinlivan）博士（核心调查员），兼职研究 协调员，两名全职研究助理，一名全日制诊所筛选员，一名兼职研究助理， 和两个兼职程序员 /计算机专家。 提供的特定服务包括：在临床设计，开发和行为方面的协助和 翻译研究，包括主题识别，招聘和同意，项目协调，获得 临床样本，数据库设计和管理； NIH Grant提交，IRB，GCRC和FDA 调查和孤儿药物申请支持；进入UNC CFAR HIV/AIDS临床研究 数据库（UNC CFAR-DB）和链接的标本存储库，包括1700多名同意参与者 日期;从临床社会人口统计学面对面调查中获取综合数据，包括 详细的行为信息；进入UNC急性HIV感染临床研究计划专业知识 和数据；并在三个UNC CFAR校园以及来自 外部机构。 Core C使用这些服务来支持包括艾滋病毒在内的大量研究 疫苗开发（AI46023，AI50246），细胞免疫学（AI20288，GM67143），HIV的生物学 传播（DK49381），急性HIV感染（MH68686），V3（信封）进化（AI44667），HIV抗性 （AI50845），HIV预防（AI46749，MH69989）和抗逆转录病毒和其他HIV临床试验（AI25868）。 Core C通过建立CFAR范围内提供了艾滋病毒/艾滋病研究传播领导 局域网（LAN），综合UNC CFAR-DB和链接的标本存储库，每月 协作研究会议和每年的艾滋病研讨会。核心C增强医学培训和 研究生，博士后研究员和初级调查人员，可以支持学生研究 项目，CFAR发展奖和K-23奖项。核心C也有助于建立富有成效的 与外部机构和行业的合作。向国际合作者和 艾滋病毒的调查人员，临床医生和社区中的艾滋病毒感染者正在进行中。