PrEP US NoW: PrEP Utilization Through Increasing Social Capital Among YBMSM Networks with Women

PrEP 现在美国：通过增加 YBMSM 女性网络中的社会资本来利用 PrEP

基本信息

批准号：
10456206
负责人：
Latesha Ellen Elopre
金额：
$ 22.06万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-23 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10456206
关键词：
AIDS prevention AIDS/HIV problem Access to Information Acquired Immunodeficiency Syndrome Address Adoption Affect Alabama Attitude Behavior Belief Black American Caring Charge Communication Complex Data Development Diagnosis Elements Emotional Epidemic Feedback Financial Support Funding Geography Guidelines HIV HIV diagnosis Health Health Promotion Health behavior Human immunodeficiency virus test Individual Intervention Interview Knowledge Link Maps Measurement Measures Mobile Health Application Modeling Motivation Outcome Participant Population Prevention Prevention approach Prevention strategy Process Public Health Randomized Randomized Controlled Trials Research Research Priority Resources Respondent Risk Role Sampling Services Sexual Health Site Social Network Social support Source Strategic Planning Structure Surveys Techniques Testing Time Training United States United States National Institutes of Health Woman Work acceptability and feasibility arm base black men who have sex with men black women comparative condomless anal sex effective intervention efficacy trial evidence base health knowledge homonegativity improved insight instrument intervention mapping mHealth member men mobile application novel novel strategies pilot trial pre-exposure prophylaxis programs recruit response scale up sexual identity social capital social norm social stigma tool treatment arm uptake usability virtual

AIDS prevention AIDS/HIV problem Access to Information Acquired Immunodeficiency Syndrome Address Adoption Affect Alabama Attitude Behavior Belief Black American Caring Charge Communication Complex Data Development Diagnosis Elements Emotional Epidemic Feedback Financial Support Funding Geography Guidelines HIV HIV diagnosis Health Health Promotion Health behavior Human immunodeficiency virus test Individual Intervention Interview Knowledge Link Maps Measurement Measures Mobile Health Application Modeling Motivation Outcome Participant Population Prevention Prevention approach Prevention strategy Process Public Health Randomized Randomized Controlled Trials Research Research Priority Resources Respondent Risk Role Sampling Services Sexual Health Site Social Network Social support Source Strategic Planning Structure Surveys Techniques Testing Time Training United States United States National Institutes of Health Woman Work acceptability and feasibility arm base black men who have sex with men black women comparative condomless anal sex effective intervention efficacy trial evidence base health knowledge homonegativity improved insight instrument intervention mapping mHealth member men mobile application novel novel strategies pilot trial pre-exposure prophylaxis programs recruit response scale up sexual identity social capital social norm social stigma tool treatment arm uptake usability virtual

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项目摘要

PROJECT SUMMARY HIV, especially in the South, disproportionately affects young Black men who have sex with men (YBMSM). Development and implementation of effective interventions to scale up HIV pre-exposure prophylaxis (PrEP) are urgently needed in this population. Prior work has focused on individual-level approaches to increasing PrEP utilization, while social network-level approaches are comparatively underutilized. Individuals within social networks have access to social capital, which can yield emotional as well as instrumental resources that influence health behaviors. Black women represent a key source of social capital within YBMSM social networks, and this unique role has not been utilized in prior PrEP interventions. We propose to leverage YBMSM’s supportive connections with Black women to develop PrEP US NoW (PrEP Utilization through increasing Social Capital among YBMSM Networks with Women), a novel mobile health intervention that will engage Black women as facilitators in existing networks of YBMSM, as a way of enhancing social capital, decreasing intersectional stigma, and promoting PrEP uptake within the network. The proposal will pursue three specific aims: (1) Qualitatively evaluate core health-promoting elements of social capital bonds between YBMSM and Black women in extant social support networks; (2) Adapt an existing, evidence-based mHealth intervention to create PrEP US NoW; and (3) Evaluate feasibility and acceptability of PrEP US NoW, as well as preliminary efficacy to increase PrEP uptake among YBMSM, in a randomized-controlled pilot trial. For Aim 1, we will conduct qualitative interviews with n=20 YBMSM and n=20 Black women to gain insights into preferred attributes of Black woman facilitators, as well as feedback on intervention content and format. In Aim 2, we will develop the PrEP US NoW mobile app. The central feature of the PrEP US NoW intervention will be real-time, virtual discussions led by a trained Black woman facilitator, delivered to an existing network of YBMSM. Additional features and content will be refined based on our Aim 1 findings. We will conduct usability testing in an iterative process with both YBMSM and Black women. In Aim 3, we will randomize YBMSM networks (up to five members each), recruited using respondent driven sampling techniques, to the intervention (PrEP US NoW) or control study arm (mHealth app without social capital components). Participants (N=60) will complete validated surveys measuring social capital, internalized homonegativity, and PrEP uptake at baseline, 1-month, and at 3-months’ time. HIV testing will be done at baseline and at 3-months’ time. We will assess feasibility, acceptability, and preliminary efficacy. This study will be conducted in an epicenter of the Southern HIV epidemic: Alabama. Upon completion of our aims, we will have collected requisite preliminary data to inform a fully powered multi-site efficacy trial. The proposed research has strong potential to inform effective HIV prevention strategies among YBMSM in the South, leading to improved individual and public health outcomes aligned with national initiatives.

项目摘要艾滋病毒，尤其是在南部，对与男性发生性关系的年轻黑人（YBMSM）的影响不成比例。开发和实施有效的干预措施以扩大艾滋病毒预防前预防（PREP）是在这个人群中迫切需要。先前的工作重点是个人级别的方法来增加准备利用率，而社交网络级别的方法相对未被充分利用。社会中的个人网络可以进入社会资本，可以产生影响的情感和工具资源健康行为。黑人妇女代表了YBMSM社交网络中社会资本的关键来源，这在事先准备干预措施中尚未使用唯一角色。我们建议利用YBMSM的支持与黑人妇女的联系立即发展我们（通过增加社会资本来准备利用在与女性的YBMSM网络中），这是一种新型的移动健康干预措施，将与黑人妇女接触 YBMSM现有网络中的促进者是增强社会资本的一种方式，减少了交叉点污名，并促进网络中的准备吸收。该提案将追求三个具体目标：（1）定性评估YBMSM和黑色之间社会资本债券的核心健康促进元素女性在额外的社会支持网络中；（2）调整现有的基于证据的MHealth干预措施来创建现在准备我们；（3）现在评估我们现在准备的可行性和可接受性，以及初步效率在一项随机控制的初步试验中，增加YBMSM之间的预备摄取。对于AIM 1，我们将进行 n = 20 ybmsm和n = 20个黑人妇女的定性访谈，以了解黑色的首选属性女性的促进者以及对干预内容和格式的反馈。在AIM 2中，我们将开发准备我们现在移动应用程序。现在，我们现在干预的中心特征将是实时的，虚拟讨论由训练有素的黑人女性主持人领导，并运送到现有的YBMSM网络。其他功能和内容将根据我们的目标1的发现进行完善。我们将在迭代过程中进行可用性测试 YBMSM和黑人妇女。在AIM 3中，我们将随机化YBMSM网络（每个最多五个成员），使用响应驱动的采样技术，干预（现在准备我们）或控制研究部门招募的招聘（没有社会资本组件的MHealth应用程序）。参与者（n = 60）将完全验证测量调查在基线，1个月以及3个月的时间时，社会资本，内部化的同性恋和预付款。艾滋病病毒测试将在基线和3个月的时间进行。我们将评估可行性，可接受性和初步功效。这项研究将在南部艾滋病毒流行病的震中：阿拉巴马州进行。完成后在我们的目标中，我们将收集必要的初步数据，以告知一项全功率的多站点效率试验。拟议的研究具有强大的潜力，可以为YBMSM中有效的HIV预防策略提供信息南部，导致改善的个人和公共卫生成果与国家倡议保持一致。