Depression and Disability in Older Persons: Untangling Complexities

老年人的抑郁和残疾：理清复杂性

• 批准号: 7531363
• 负责人: LISA C BARRY
• 金额: $ 12.57万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7531363
• 关键词: Accounting; Address; Age; Aging; Clinical Trials; Complement; Complex; Data; Data Collection; Development; Elderly; Epidemiologist; Epidemiology; Event; Feedback; Funding; Gender; Goals; Grant; Hand; Knowledge; Lead; Leadership; Learning; Light; Link; Longitudinal Studies; Mediating; Mediator of activation protein; Mental Depression; Mentored Research Scientist Development Award; Methodology; Nature; Numbers; Participant; Pattern; Principal Investigator; Psychosocial Factor; Reporting; Research; Research Personnel; Research Training; Testing; Thinking; Time; Training; Woman; Work; Writing; base; career; clinically relevant; community living; design; disability; disability burden; experience; functional decline; functional status; geriatric depression; improved; innovation; knowledge base; medical schools; men; older women; prevent; programs; psychosocial; skills; trait

DESCRIPTION (provided by applicant): This amended proposal is for a K01 Mentored Research Scientist Development Award. The applicant is an epidemiologist and developing investigator at the Yale School of Medicine. Her goal is to become an expert and leader in the epidemiology of aging at the interface of psychosocial epidemiology and functional status. Her approach to achieving this goal is to learn advanced statistical methodology to elucidate the relationship between depression and disability over time in light of the emerging paradigm of disability as dynamic and highly complex. The proposed training and research plans are designed to complement and reinforce one another. The specific training objectives are to (1) acquire expertise in the epidemiology of disability and depression and obtain new skills in primary data collection; (2) develop expertise in the analysis of complex longitudinal data; (3) develop and refine a set of "survival" skills that are critical for a successful career as an independent investigator (e.g., grant writing); and (4) enhance her knowledge base regarding innovative research in aging. A secondary goal is to gain "hands-on" knowledge of the development and implementation of clinical trials research. The proposed research is designed to rigorously evaluate the reciprocal nature of the relationship between depression and disability, operationalized as disability burden and clinically-meaningful subtypes. Additionally, the applicant proposes to systematically determining the mechanisms that underlie the reciprocal relationship between depression and disability, and to evaluate if this relationship differs according to gender. The research will be conducted using data from the Yale PEP (Precipitating Events Project) Study, an ongoing NIA-funded, longitudinal study of 754 initially non-disabled community-living older persons. The conceptual and methodological challenges of using these data to test hypotheses directed at determining if a feedback loop exists between depression and disability over time will reinforce the applicant's formal training. Research that improves our understanding of how depression influences the complex trajectory of disability is highly significant to the field of aging; it will highlight a factor that, if adequately identified and managed, could help to prevent the development and progression of disability. Alternately, improving our understanding of this relationship may help to identify opportunities to prevent the development and progression of depression.

描述（由申请人提供）：该修订的建议是为K01指导的研究科学家发展奖。申请人是耶鲁大学医学院的流行病学家和开发研究人员。她的目标是成为心理社会流行病学和功能状况界面衰老流行病学的专家和领导者。她实现这一目标的方法是学习先进的统计方法论，以鉴于新兴的残疾范式是动态和高度复杂的新兴范式。拟议的培训和研究计划旨在补充和加强彼此。具体的培训目标是（1）获得残疾和抑郁症流行病学方面的专业知识，并获得主要数据收集的新技能； （2）在分析复杂纵向数据时发展专业知识； （3）发展和完善一组“生存”技能，这对于成功作为独立研究者的职业至关重要（例如，授予写作）； （4）增强她有关衰老创新研究的知识基础。第二个目标是获得有关临床试验研究的发展和实施的“动手”知识。拟议的研究旨在严格评估抑郁与残疾之间关系的相互性质，该性质是残疾负担和临床上含量的亚型。此外，申请人建议系统地确定抑郁与残疾之间相互关系的机制，并评估这种关系是否根据性别有所不同。这项研究将使用耶鲁PEP（促进事件项目）研究的数据进行，这是一项持续的NIA资助，纵向研究，对754个最初是非可残疾的社区生活的老年人。使用这些数据来测试旨在确定抑郁症和残疾之间是否存在反馈回路的概念和方法论挑战将加强申请人的正式培训。提高我们对抑郁症如何影响残疾复杂轨迹的研究对衰老领域非常重要。它将突出一个因素，如果得到充分识别和管理，可以帮助防止残疾的发展和发展。另外，提高我们对这种关系的理解可能有助于确定防止抑郁症发展和发展的机会。