Pilot and Exploratory Core PESC

试点和探索性核心 PESC

• 批准号: 10294033
• 负责人: LISA C BARRY
• 金额: $ 31.3万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10294033
• 关键词: Address; Adult; African American; Aging; American; Applications Grants; Area; Award; Behavior Therapy; COVID-19; Capsicum; Clinical Research; Clinical Trials; Data; Data Analyses; Data Collection; Department chair; Depressed mood; Development; Educational Intervention; Elderly; Electronic Mail; Ensure; Faculty; Fostering; Functional disorder; Funding; Future; Generations; Geriatrics; Gerontology; Goals; Grant; Health; Heterogeneity; Human Subject Research; Institutional Review Boards; Interdisciplinary Study; Journals; Knowledge; Lead; Manuscripts; Mental Depression; Mental Health; Monitor; Online Systems; Outcome; Peer Review; Performance; Physical Function; Physical activity; Pilot Projects; Population Sciences; Positioning Attribute; Process; Protocols documentation; Publishing; Request for Applications; Research; Research Design; Research Personnel; Research Support; Resources; Selection Criteria; Series; Specific qualifier value; Testing; Time; United States National Institutes of Health; Universities; biomarker discovery; biomarker validation; blood-based biomarker; career; career development; clinical phenotype; cohort; disability; early detection biomarkers; education research; experience; frailty; human subject; improved; innovation; large datasets; meetings; new technology; novel; nutrition; ranpirnase; recruit; success; validation studies; web site; webinar

PESC ABSTRACT/SUMMARY The Pilot and Exploratory Studies Core (PESC) will promote the development of novel ideas and approaches to improving and sustaining independent function in older persons through Precision Gerontology. Using a rigorous application and selection process developed to maximize the pipeline of investigators pursuing Precision Gerontology, the PESC will select up to 3 pilot and exploratory studies (PES) each year of the award. Selection criteria specified in the Request for Applications (RFA) will include the potential to lead to larger high-impact projects, involvement of Pepper Cores, and responsiveness to the UConn Pepper Center focus on Precision Gerontology. PESC-funded projects can include a range of study designs from basic bench and human subject research to population science. The PESC seeks to fund three(PES) in Year 1 that each emphasize enhanced understanding of heterogeneity with aging and/or improved targeting in aging. PES1, Apathy: An Early Manifestation of Frailty and Disability in Older Adults with Depression?, will test the hypotheses that there will be differences in functional performance and blood-based biomarkers between older depressed adults with and without apathy. The results of this study will enhance understanding the pathophysiology underlying apathy and may help identify treatment targets in older depressed adults. PES2, Multicomponent web-based behavioral intervention to improve physical function and other health outcomes among African American older adults in the COVID-19 era, will develop, implement, and evaluate a multicomponent, culturally-tailored educational intervention to reengage and promote physical activity, adequate nutrition, and optimal mental health for African American older adults. PES3, The Heterogeneity of Vulnerabilities in Aging Cohort (HVAC): A new resource for early biomarker discovery and validation, seeks to provide junior faculty with: (1) experience in preparing an IRB protocol, recruiting human subjects, and assessing frailty; and (2) the opportunity to generate data that can be used to develop a platform for biomarker discovery and for future NIH grant applications. These goals will be accomplished using a cohort of well-defined geriatric clinical phenotypes that are associated with particular types of vulnerability or frailty. Metrics of success for each PES will include generation of preliminary data to support external NIH grant applications and dissemination of knowledge via presentations and manuscripts. Overall success of the PESC Core will be assessed in terms of responsiveness to the RFA and number of peer-reviewed manuscripts, submitted applications, and external funding generated from PESC-funded studies.

PESC摘要/摘要 飞行员和探索性研究核心（PESC）将促进新思想和方法的发展 通过精确的老年医学来改善和维持老年人的独立功能。使用严格 开发的应用和选择过程是为了最大程度地提高调查人员的渠道 老年医学，PESC每年将在奖项的每年选择最多3个试点和探索性研究（PES）。选择 申请请求（RFA）中指定的标准将包括导致更大高影响力的潜力 项目，胡椒核的参与以及对UConn Pepper中心的响应能力专注于精确度 老年学。 PESC资助的项目可以包括基本基础和人类主题的一系列研究设计 研究人口科学。 PESC试图在第1年的三（PES）资助每个人都强调增强 了解异质性通过衰老和/或改善衰老的靶向靶向。 PES1，冷漠：早期 抑郁症老年人的脆弱和残疾表现？ 年龄较大的成年人和患有血液的功能性能和基于血液的生物标志物的差异和 没有冷漠。这项研究的结果将增强理解冷漠的病理生理学和 可能有助于识别老年抑郁症的治疗靶标。 PES2，基于多组件的基于Web的行为 干预以改善非裔美国人老年人的身体机能和其他健康状况 COVID-19时代将开发，实施和评估多组分的文化教育 干预以重新接触和促进体育锻炼，适当的营养以及为非洲的最佳心理健康 美国老年人。 PES3，衰老队列中脆弱性的异质性（HVAC）：一种新资源 早期的生物标志物发现和验证，试图为初级教师提供：（1）准备IRB的经验 协议，招募人类受试者和评估脆弱； （2）生成可以成为的数据的机会 用于开发生物标志物发现和未来NIH赠款应用程序的平台。这些目标将是 使用与特定类型相关的一系列定义明确的老年临床表型完成 脆弱性或脆弱性。每个PES成功的指标将包括生成初步数据以支持 外部NIH授予应用程序和通过演示和手稿传播知识。全面的 PESC核心的成功将根据对RFA的响应能力和同行评审的数量进行评估 由PESC资助的研究产生的手稿，提交的申请和外部资金。