Sex Differences in Drug Effects: The Adolescent Trajectory

药物作用的性别差异：青少年轨迹

• 批准号: 7333538
• 负责人: Emmalee S. Bandstra
• 金额: $ 25.25万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7333538
• 关键词: Adolescence; Adolescent; Adult; Age; Alcohols; Autoradiography; Behavior; Behavioral; Biological Assay; Brain; Cannabinoids; Clinical; Cocaine; Condition; Daily; Data; Development; Dopamine; Dopamine D2 Receptor; Drug Addiction; Drug usage; Environment; Epidemiologic Studies; Exposure to; Female; Goals; Harvest; Housing; In Situ Hybridization; Incidence; Laboratory Study; Lead; Life; Male Adolescents; Marijuana; Measures; Motor Activity; Nicotine; Nicotinic Receptors; Pattern; Pharmaceutical Preparations; Rattus; Regulation; Reporting; Research Personnel; Self Administration; Sex Characteristics; Staging; Stress; Substance abuse problem; Techniques; Testing; Time; cannabinoid receptor; cohort; day; dopamine transporter; drug of abuse; male; neurochemistry; novel; preference; programs; receptor; receptor binding; response; sex; uptake

Epidemiological studies have suggested that exposure to drugs such as nicotine and marijuana during adolescence is correlated with a significantly higher incidence of subsequent use of other drugs such as cocaine. In addition, there are different responses between female and male adolescents in response to drug use.Animal laboratory studies have shown that female and male rats respond differently to drugs and that the neurochemical adaptations that occur also differ. Studies have shown that drug administration during adolescence leads to differential neurochemical and behavioral effects than drug administration during adulthood. In addition, many of the effects of drugs during this critical developmental period have long- lasting effects that persist into adulthood. In general, the studies suggest that there may be an increased vulnerability to the effects of drugs during adolescence and that the effects differ across both sex andage. The main hypothesis of this proposal is that females and males will respond differently to drugs during different stages of development and that it may therefore be necessary to develop sex-and age-specific treatments for drug addiction. The focus of this proposal is to study the effects of nicotine, marijuana(A9- THC) and cocaine in female and male adolescent and adult rats on behavior and neurochemistry during adolescence and later during adulthood. In addition, the effects of environment on the changes produced by these drugs will be examined. An understanding of the differential effects of drugs in females and males during adolescence, and of how these changes use impact drug effects in adults may lead to sex-andage- specific treatments for drug addiction.

流行病学研究表明，在尼古丁和大麻等药物期间的暴露 青春期与随后使用其他药物（例如 可卡因。此外，女性和男性青少年之间有不同的反应 药物使用。动物实验室研究表明，雌性和雄性大鼠对药物的反应不同 发生的神经化学适应也有所不同。研究表明，药物给药期间 与药物给药相比，青春期导致差异性神经化学和行为影响 成年。此外，在这个关键发育时期，药物的许多作用具有长期 持续到成年的持久影响。通常，研究表明可能有增加 青春期药物作用的脆弱性，并且在性别和性别之间的影响有所不同。 该提议的主要假设是，女性和男性对药物的反应不同 发展的不同阶段，因此可能有必要发展性别和年龄特定 吸毒的治疗方法。该提案的重点是研究尼古丁大麻的影响（A9-- 在女性和男性青少年和成年大鼠的行为和神经化学期间的THC）和可卡因 青春期和成年后的后期。另外，环境对由 这些药物将被检查。对女性和男性药物的差异作用的理解 在青春期以及这些变化如何使用影响成人的药物影响可能会导致性别 - 药物成瘾的特定治疗方法。