NCCTG Biospecimen Resource

NCCTG 生物样本资源

基本信息

批准号：
7282444
负责人：
JAN C BUCKNER
金额：
$ 85.78万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-08-17 至 2010-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7282444
关键词：
Agreement Apple Blood and Blood Products Cancer Patient Clinic Clinical Clinical Trials Cooperative Group Collection Commit Communities Compatible Condition Confusion Data Databases Development Disease Outcome Enrollment Evaluation Facility Construction Funding Category Feces Formalin Freezing Genomics Geographic Locations Goals Indium Link Mainstreaming Measures Methodology Methods Mission North Central Cancer Treatment Group Numbers Oranges Paraffin Embedding Pathologic Patients Procedures Process Protocols documentation Qualifying Quality of life RNA Recommendation Research Research Personnel Resources Retrieval Saliva Services Specimen Sputum Standards of Weights and Measures System Technology Tissue Microarray Tissues Translational Research Urine cancer Biomedical Informatics Grid improved indexing neoplastic cell response sample collection translational study

项目摘要

DESCRIPTION (provided by applicant): The mission of the North Central Cancer Treatment Group (NCCTG) is to improve the duration and quality of life of cancer patients by performing high-quality clinical and translational research in the community setting. The NCCTG (Biospecimen Resource will support the NCCTG mission by providing superior biospecimens from patients enrolled on NCCTG trials that 1) are fully and consistently annotated, 2) have been collected under optimized standard conditions, 3) have undergone quality assessment, and 4) are stored under controlled conditions allowing efficient retrieval for distribution to qualified researchers. The five specific aims of this application are 1) To maximize collection of biospecimens from patients enrolled on NCCTG and other cooperative group clinical trials. This aim will serve to increase the numbers of biospecimens available for translational research so that more studies with sufficient statistical power can be accommodated; 2) To consistently and completely annotate biospecimens collected. This aim will serve to provide a crucial element in translational research, namely to define the context of standard clinical-pathologic indices, treatments, response to treatment, and disease outcome within which the significance of the measured biologic parameters of translational studies will be evaluated; 3) To develop standard operating procedures (SOP) for collecting, processing, and storing biospecimens. The use of SOPs will enhance the Biospecimen Resource by providing uniformity so that biospecimens for a given translational study are comparable with one another; 4) To develop new methods for analysis of biospecimens. Technologies are constantly developing that expand our ability to analyze biospecimens. In this aim we describe three technologies that we are refining (tissue microarray construction) and developing (analysis of circulating tumor cells and extraction of RNA from formalin-fixed paraffin embedded tissue blocks) as examples of new methodologies that expand the use of biospecimens; and 5) To provide oversight to the resource and a mechanism for access to the resource for the research community. This aim will describe the oversight of the Biospecimen Resource and how we will provide a public link to the mechanism for requesting biospecimens. A prioritization system and evaluation criteria are defined.

描述（由申请人提供）：北中央癌症治疗组（NCCTG）的任务是通过在社区环境中进行高质量的临床和转化研究来改善癌症患者的持续时间和质量。 NCCTG（Biospecimen资源将通过提供NCCTG试验的患者的出色生物测量来支持NCCTG任务，该试验已完全且一致地注释，2）在优化的标准条件下收集了2），3）3）进行了质量评估，4）AH）。存储在受控条件下，允许有效检索到合格的研究人员。本应用的五个具体目的是1）最大化参加NCCTG和其他合作组临床试验的患者的生物测量收集。该目标将有助于增加可用于转化研究的生物测量数量，以便可以容纳更多具有足够统计能力的研究； 2）一贯并完全注释收集的生物测量。该目标将在转化研究中提供关键因素，即定义标准临床病理指数，治疗，对治疗的反应以及疾病结果的背景，其中将评估转化研究的生物学生物学参数的重要性； 3）开发用于收集，加工和存储生物测量的标准操作程序（SOP）。 SOP的使用将通过提供均匀性来增强生物测量资源，从而使给定翻译研究的生物测量彼此相媲美。 4）开发新方法以分析生物测量。技术正在不断发展，以扩大我们分析生物测量的能力。在此目的中，我们将我们正在精炼的三种技术（组织微阵列结构）和发展（分析循环肿瘤细胞的分析以及从福尔马林固定的石蜡嵌入的组织块中提取RNA）是扩大生物蛋白质使用的新方法的典范； 5）为了提供资源的监督，以及用于访问研究界资源的机制。这个目标将描述对生物测量资源的监督，以及我们将如何提供与请求生物测量机制的公共联系。定义了优先级系统和评估标准。