International Population Study on Macronutrients and BP - INTERMAP

关于常量营养素和血压的国际人口研究 - INTERMAP

• 批准号: 7910478
• 负责人: Martha L Daviglus
• 金额: $ 61.14万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-07-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7910478
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DESCRIPTION (provided by applicant): This application requests support for data analyses/ biochemical analyses - - particularly on foods/food groups/food subgroups/their combinations (patterns)/food preparation methods/eating patterns/food- related urinary metabolites and blood pressure (BP) (hypothesis testing and exploratory analyses) - - in the international cooperative INTERMAP Study. INTERMAP is a basic epidemiologic investigation on the role of dietary factors (foods/macro-/micronutrients)/ their urinary metabolites in the etiopatho- genesis population-wide of unfavorable BP levels, including the even more adverse BP patterns of lower socioeconomic (SES) population strata, particularly African-Americans. The multidisciplinary INTERMAP research effort -- based in Chicago and London -- aims to achieve a major advance on these important issues, in a highly cost effective way, based on its vast, unique, in-hand database for 4,680 men and women ages 40-59 from 17 population samples of diverse ethnicity/ SES/ eating practices in four countries (China, Japan, UK, USA). These high-quality standardized data are from four in-depth multi-pass 24-hour dietary recalls/person with computerization of all reported foods/ dietary supplements classified into 23 groups and 119 subgroups, their conversion into nutrients (total: 83); two timed 24-hour urine collections/person with measurement of 24-hour volume, Na, K, Ca, Mg, creatinine, urea, macro-/ microalbuminuria, 23 amino acids, nuclear magnetic resonance (NMR) metabolomic scanning for metabolites, eight BP measurements/person at four visits, height, weight, extensive questionnaire data. In 2003-2008 data were reported on influences of multiple individual macro-/micronutrients /urinary metabolites on BP, and on higher BP of lower SES Americans, and northern compared to southern Chinese. Specific aims for 2009-2014 involve elucidating influences on BP of multiple foods/ food groups/ food subgroups/ their combinations (patterns)/ food preparation methods/ eating patterns/food-related urinary metabolites. Primary hypotheses are on relation of 9 foods/ food groups to BP. Analyses are also to explore relations of food intakes/ eating patterns to urinary metabolites (metabolomic analyses), and role of these food/ eating/ metabolic factors in accounting for higher BP levels of lower SES Americans, African-Americans, and northern Chinese. Findings are to be used to estimate favorable impact on BP of multiple improvements in eating patterns by populations, i.e., to enhance dietary recommendations for primary prevention/ control of prehypertension/hypertension with consequence sizable reduction in cardiovascular disease risks. PUBLIC HEALTH RELEVANCE: LAY SUMMARY Normal blood pressure is rare among Americans ages 35 years and older. Adverse blood pressure levels are due to prevailing adverse lifestyles, first and foremost unfavorable dietary patterns. The ongoing INTERMAP Study, an international cooperative study of almost 5,000 women and men ages 40-59 from the United States, China, Japan, and the United Kingdom, has been investigating the specific details of the diet-blood pressure link. INTERMAP has already contributed to the current knowledge on the role of several specific dietary factors in influencing blood pressure adversely - - high salt intake, inadequate intakes of vegetable protein, potassium/calcium/magnesium/phosphorus/iron, and also overweight/obesity, excess alcohol consumption. During the next years (2009-2014), INTERMAP aims to focus in detail on multiple specific foods, food preparation and intake patterns, food influences on body metabolism and their relations to the population-wide blood pressure problem.

描述（由申请人提供）：本申请要求支持数据分析/生化分析 - 尤其是食品/食品组/食品组/食品亚组/它们的组合（模式）/食物制备方法/饮食模式/相关的尿液代谢物和血压（BP）（BP）（BP）（假设测试和探索性分析） - 国际合作式研究。映射是对饮食因素（食物/宏观/微量营养素）/其尿尿代谢物在不利BP水平的整体种群中的作用的基本流行病学研究，包括较低的社会经济阶层（SES）种群中的较低的BP BP模式，包括更不利的BP BP模式。基于芝加哥和伦敦的多学科间绘图研究工作旨在以高度成本有效的方式在这些重要问题上取得重大进步，基于其庞大，独特的，杂乱无章的数据库，适用于40-680名40-59岁的男女，从17个人口中的17个人口样本中，有多种种族/ SES/ SES/ SES/ SES/ SES/ SES/ SES/ SES/ SES/ SES/ SES/饮食习惯（中国，日本，英国，美国）。这些高质量的标准化数据来自四个深入的多通行24小时饮食召回/人，包括所有报道的食品/饮食补充剂分为23组和119个亚组的计算机化，它们的转化为营养素（总计：83）；两个定时的24小时尿液收集/人，具有24小时体积的测量，Na，K，Ca，Mg，肌酐，肌酐，尿素，宏观/微藻尿症，23个氨基酸，核磁共振（NMR）代谢物的代谢物扫描代谢物，八个BP测量/八个BP测量/人，在四个BP测量中/vister/persive vistress/persiver/persiver，高度，高度，高度，次数，范围，次数，范围，范围，范围。在2003年至2008年，与南部中国人相比，据报道了多种单独的宏观 /微量营养素 /泌尿代谢产物对BP的影响以及较高的BP的影响，以及北部的北部。 2009 - 2014年的具体目的涉及阐明对多个食品/食物组/食物亚组/其组合（模式）/食物制备方法/饮食模式/与食物相关的尿相关代谢物的BP的影响。主要的假设是关于BP的9种食物/食品组的关系。分析还旨在探索食物摄入量/饮食模式与泌尿代谢产物（代谢组分析）的关系，以及这些食物/饮食/饮食/代谢因素的作用在计算较高的BP水平较高的下SES美国人，非裔美国人和北方中国人。调查结果应用于估计人群对饮食模式的多种改进的BP的有利影响，即增强饮食建议，以促进饮食建议，以降低高血压前/高血压的一级预防/控制，并在心血管疾病风险中大大降低。公共卫生相关性：总结正常血压在35岁及以上的美国人中很少见。不良血压水平是由于盛行的不利生活方式，首先是不利的饮食模式。这项正在进行的Intermap研究是一项国际合作研究，对来自美国，中国，日本和英国的近5,000名40-59岁男性和男性的国际合作研究一直在研究饮食饮食压力链接的具体细节。 Intermap已经有助于当前关于几种特定饮食因素在影响血压的作用的知识 - 高盐的摄入量，植物蛋白的摄入量不足，钾/钙/钙/磷/磷/铁，超重/肥胖，过多的酒精消耗。在未来几年（2009-2014）中，Intermap旨在详细关注多种特定食物，食物制备和摄入量，食物对人体代谢的影响以及它们与人口范围的血压问题的关系。