International Population Study on Macronutrients and BP - INTERMAP

关于常量营养素和血压的国际人口研究 - INTERMAP

• 批准号: 8077968
• 负责人: Martha L Daviglus
• 金额: $ 60.87万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-07-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8077968
• 关键词: Accounting; Achievement; African American; Age; Alcohol consumption; Alcohols; American; Amino Acids; Apple; Banana; Berry; Biochemical; Biometry; Blood Pressure; Bread; Butter; Calcium; Calories; Carthamus tinctorius; Cellular Structures; Cereals; Cherry - dietary; Chicago; China; Chinese People; Citrus; Collection; Cottonseed; Country; Creatinine; Dairy Products; Data; Data Analyses; Data Set; Databases; Diet; Dietary Factors; Dietary Fiber; Dietary Practices; Domestic Fowls; Eating; Epidemiologic Studies; Ethnic Origin; Excretory function; Fabaceae; Family; Fatty acid glycerol esters; Figs - dietary; Fishes; Flax; Food; Food Patterns; Food Processing; Fresh Water; Friends; Fruit; Furuncles; Gender; Grant; Hand; Health Professional; Heavy Drinking; Height; Home environment; Hour; Hypertension; Ice Cream; Individual; Intake; International; Iron; Japan; Joints; Journals; Juice; Knowledge; Life Style; Link; Liquid substance; London; Macronutrients Nutrition; Magnesium; Marines; Measurement; Meat; Melons; Metabolic; Metabolism; Methods; Microalbuminuria; Micronutrients; National Heart, Lung, and Blood Institute; Nature; Not Hispanic or Latino; Nuclear Magnetic Resonance; Nurses; Nutrient; Nuts; Obesity; Olives - dietary; Overweight; Participant; Pattern; Peach; Pear; Peer Review; Persons; Phase; Phosphorus; Pineapple (Fruit); Plum; Population; Population Study; Potassium; Preparation; Primary Prevention; Process; Progress Reports; Publishing; Questionnaires; Recommendation; Reporting; Request for Applications; Research; Rice; Role; Sampling; Scanning; Seafood; Seeds; Shellfish; Site; Specimen; Steam; Subgroup; Sunflowers; Techniques; Testing; Time; United Kingdom; United States; Urea; Urine; Vegetable Oils; Vegetable Proteins; Vegetables; Visit; Weight; Woman; Work; base; beef; cardiovascular disorder risk; caucasian American; cooking; cooperative study; cost effective; density; dietary supplements; egg; food preparation; fruits and vegetables; lard; meetings; men; metabolomics; microwave electromagnetic radiation; multidisciplinary; salt intake; socioeconomics; soy; sugar; urinary

DESCRIPTION (provided by applicant): This application requests support for data analyses/ biochemical analyses - - particularly on foods/food groups/food subgroups/their combinations (patterns)/food preparation methods/eating patterns/food- related urinary metabolites and blood pressure (BP) (hypothesis testing and exploratory analyses) - - in the international cooperative INTERMAP Study. INTERMAP is a basic epidemiologic investigation on the role of dietary factors (foods/macro-/micronutrients)/ their urinary metabolites in the etiopatho- genesis population-wide of unfavorable BP levels, including the even more adverse BP patterns of lower socioeconomic (SES) population strata, particularly African-Americans. The multidisciplinary INTERMAP research effort -- based in Chicago and London -- aims to achieve a major advance on these important issues, in a highly cost effective way, based on its vast, unique, in-hand database for 4,680 men and women ages 40-59 from 17 population samples of diverse ethnicity/ SES/ eating practices in four countries (China, Japan, UK, USA). These high-quality standardized data are from four in-depth multi-pass 24-hour dietary recalls/person with computerization of all reported foods/ dietary supplements classified into 23 groups and 119 subgroups, their conversion into nutrients (total: 83); two timed 24-hour urine collections/person with measurement of 24-hour volume, Na, K, Ca, Mg, creatinine, urea, macro-/ microalbuminuria, 23 amino acids, nuclear magnetic resonance (NMR) metabolomic scanning for metabolites, eight BP measurements/person at four visits, height, weight, extensive questionnaire data. In 2003-2008 data were reported on influences of multiple individual macro-/micronutrients /urinary metabolites on BP, and on higher BP of lower SES Americans, and northern compared to southern Chinese. Specific aims for 2009-2014 involve elucidating influences on BP of multiple foods/ food groups/ food subgroups/ their combinations (patterns)/ food preparation methods/ eating patterns/food-related urinary metabolites. Primary hypotheses are on relation of 9 foods/ food groups to BP. Analyses are also to explore relations of food intakes/ eating patterns to urinary metabolites (metabolomic analyses), and role of these food/ eating/ metabolic factors in accounting for higher BP levels of lower SES Americans, African-Americans, and northern Chinese. Findings are to be used to estimate favorable impact on BP of multiple improvements in eating patterns by populations, i.e., to enhance dietary recommendations for primary prevention/ control of prehypertension/hypertension with consequence sizable reduction in cardiovascular disease risks.

描述（由申请人提供）：此申请要求支持数据分析/生化分析 - 尤其是食品/食品组/食品亚组/它们的组合（模式）/食品制备方法/饮食模式/相关的尿液代谢物和血压（BP）（假设检验和探索性分析） - 在国际合作Intermap研究中。映射是对饮食因素（食物/宏观/微量营养素）/其尿液代谢物在不利的BP水平范围内的尿中代谢物的基本流行病学研究，包括较低社会经济学（SES）（SES）的不良BP模式，包括更加不良的BP模式。人口层，特别是非裔美国人。总部位于芝加哥和伦敦的多学科互化研究工作旨在以高度成本效益的方式取得重大进步，以其庞大，独特的，独特的，手中的数据库，适用于40岁的40岁的男女-59在四个国家（中国，日本，英国，美国）的17种种族/ SES/饮食实践的17个人口样本中。这些高质量的标准化数据来自四个深入的多通行24小时饮食召回/人，包括所有报道的食品/饮食补充剂分为23组和119个亚组的计算机化，它们的转化为营养素（总计：83）；两个定时的24小时尿液收集/人，测量为24小时的体积，Na，K，Ca，mg，肌酐，肌酐，尿素，宏观/微藻尿症，23个氨基酸，核磁共振（NMR）代谢物的代谢物，八个代谢物，八个BP测量/人员四次访问，身高，体重，广泛的问卷数据。在2003年至2008年，与南部中国人相比，据报道了多种单独的宏观 /微量营养素 /泌尿代谢产物对BP的影响以及较高的BP的影响，以及北部的北部。 2009 - 2014年的具体目的涉及阐明对多个食品/食物组/食物亚组/其组合（模式）/食物制备方法/饮食模式/与食物相关的尿相关代谢物的BP的影响。主要的假设是关于BP的9种食物/食品组的关系。分析还旨在探索食物摄入量/饮食模式与泌尿代谢产物（代谢组分析）的关系，以及这些食物/饮食/饮食/代谢因素的作用在计算较高的BP水平较高的下SES美国人，非裔美国人和北方中国人。调查结果应用于估计人群对饮食模式的多种改进的BP的有利影响，即增强饮食建议，以促进饮食建议，以降低高血压前/高血压的一级预防/控制，并在心血管疾病风险中大大降低。