Alliance NCORP Research Base

联盟NCORP研究基地

• 批准号: 8790220
• 负责人: JAN C BUCKNER
• 金额: $ 963.03万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8790220
• 关键词: Academic Medical Centers; Address; Affect; Aftercare; American; Behavior; Biological; Biological Markers; Blood; Cancer Burden; Cancer Patient; Clinical; Clinical Trials; Clinical Trials Network; Collection; Communities; Community Clinical Oncology Program; Community Practice; Companions; Data; Databases; Diagnosis; Disease; Economics; Education; Enrollment; Functional disorder; Funding; Genetic; Geriatric Assessment; Health; Human; Incidence; Individual; Intervention; Laboratories; Malignant Neoplasms; Manuscripts; Mission; Modeling; Monitor; Morbidity - disease rate; National Cancer Institute; Natural History; Newly Diagnosed; Organizational Change; Outcome; Outcomes Research; Patient Outcomes Assessments; Patient-Focused Outcomes; Patients; Pharmacologic Substance; Physiological; Population; Premalignant; Prevalence; Prevention strategy; Provider; Quality of life; Recurrence; Recurrent Malignant Neoplasm; Research; Research Methodology; Research Personnel; Research Priority; Risk; Role; Science; Site; Solutions; Source; Staging; Symptoms; System; Tissue Sample; Toxic effect; Translational Research; Tumor Tissue; Underrepresented Minority; United States; Woman; abstracting; base; cancer care; cancer diagnosis; cancer prevention; cancer risk; cancer therapy; care delivery; clinical practice; clinically significant; comparative effectiveness; data sharing; effectiveness research; experience; functional decline; health disparity; health economics; improved; improved functioning; innovation; member; men; mortality; multidisciplinary; older patient; oncology; population health; prevent; programs; repository; screening; survivorship; tool; translational study

DESCRIPTION (provided by applicant): The Alliance NCI Community Oncology Research Program (NCORP) Research Base conducts interventional and observational clinical trials as well as database analyses addressing important questions concerning cancer prevention, screening, symptom intervention, post-treatment surveillance/survivorship, quality of life and cancer care delivery. We place special emphasis upon issues affecting minority, underserved and elderly patient groups, and upon building strong collegial relationships with NCORP Community sites and Minority/Underserved Community sites. The Alliance for Clinical Trials in Oncology (Alliance), one of the five National Clinical Trials Network (NCTN) groups, serves as the coordinating center for the conduct of all NCORP Research Base trials. The Alliance members represent community practices and academic medical centers in approximately equal number, so the results of the trials broadly reflect the actual experience of patients across the United States. In order to improve our understanding of the biological basis of cancer risk and pre-malignant disease, biomarkers that detect pre-symptomatic newly diagnosed or recurrent malignancies, as well as the physiologic mechanisms of cancer-related symptoms and treatment-related toxicities, most of our clinical trials include translational research questions requiring the collection of tumor tissue, premalignant tissue samples, blood, or other human biospecimens. These biospecimens create an invaluable repository for understanding the associations between laboratory and clinical observations. The Alliance NCORP Research Base collaborates broadly with other NCORP Research Bases to enroll patients in trials, conduct translational studies, and share data and biospecimens for pooled analyses. We also collaborate broadly with other NCI-funded investigators and consortia, as well as investigators supported through non-NCI sources. Results of Alliance investigator efforts have resulted in more than 99 abstracts and manuscripts over the past five years, many resulting in significant beneficial changes in clinical practice. The scientific questions answered by the Alliance NCORP Research Base represent meaningful and innovative contributions to biomedical sciences, and can only be addressed through a publicly-funded research network.

描述（由申请人提供）：联盟 NCI 社区肿瘤​​学研究计划 (NCORP) 研究基地开展介入性和观察性临床试验以及数据库分析，解决有关癌症预防、筛查、症状干预、治疗后监测/生存、质量等重要问题生命和癌症护理服务。我们特别重视影响少数群体、服务不足和老年患者群体的问题，并与 NCORP 社区站点和少数群体/服务不足社区站点建立牢固的同事关系。肿瘤临床试验联盟（联盟）是五个国家临床试验网络 (NCTN) 小组之一，作为所有 NCORP 研究基地试验进行的协调中心。联盟成员代表的社区实践和学术医疗中心的数量大致相等，因此试验结果广泛反映了美国各地患者的实际经历。为了提高我们对癌症风险和癌前疾病的生物学基础、检测新诊断或复发性恶性肿瘤症状前的生物标志物，以及癌症相关症状和治疗相关毒性的生理机制的理解，大多数我们的临床试验包括需要收集肿瘤组织、癌前组织样本、血液或其他人类生物样本的转化研究问题。这些生物样本为了解实验室和临床观察之间的关联创建了宝贵的存储库。联盟 NCORP 研究基地与其他 NCORP 研究基地广泛合作，招募患者参加试验，进行转化研究，并共享数据和生物样本以进行汇总分析。我们还与其他 NCI 资助的研究人员和财团以及通过非 NCI 来源支持的研究人员广泛合作。在过去的五年里，联盟研究者的努力已经产生了超过 99 份摘要和手稿，其中许多给临床实践带来了重大的有益变化。联盟 NCORP 研究基地回答的科学问题代表了对生物医学科学的有意义和创新的贡献，并且只能通过公共资助的研究网络来解决。