Erice School of Biophysics Conference on Channels and Transporters

埃里斯生物物理学院通道和转运蛋白会议

基本信息

批准号：
7608708
负责人：
LOUIS J DE FELICE
金额：
--
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-04-15 至 2011-03-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): We request support for the third International School of Biophysics conference on "Transporters and Channels" to be held in Erice, Sicily, 12-18 May 2008. We also request a continuation meeting to be held in 2011. The 2008 meeting is a sequel to the 2002 and NIMH-supported 2005 meetings. The 2008 meeting was planned to occur just before a complementary meeting organized by Frances Ashcroft in London. Students and speakers from the Erice conference may thus continue to London. Few meetings pay exclusive attention to the relationship between transporters and channels, but focus instead on transporters or channels with little crosstalk. Numerous reviews, new research, and recent conferences like ours have changed this landscape. Nevertheless, young researchers may be unaware of career opportunities offered by a comprehensive and comparative view of transporters and channels. Channel- and transporter-related diseases, protein regulation, molecular dynamics, and drug discovery are a few examples of intersecting research areas. Thus, there is a continuing need for a meeting with lecturers and participants from both disciplines. The Erice meeting - which is modeled after Gordon Research Conferences but with emphasis on an interdisciplinary, early career audience - offers unprecedented opportunities for interactions between channel and transporter researchers for professional contacts and opportunities. Transporters and channels are crucial for virtually every cell function, including synaptic transmission, metabolic and nutrient transport, water and ion homeostasis, and excitability. The list of diseases linked to transporter and channel mutations is growing. Transporters also have current-generating conformations, but little is understood about the physiological role of the endogenous channel states in transporters or about the structural correlates of these channel states. The series of lectures we propose includes background sessions, workshops, and seminars. Leading researchers from ion channel and transporter fields have agreed to take part, and we will accept students from all fields with a view toward information exchange and cross-fertilization. The program will cover ligand- and voltage-gated ion channels, Na-coupled neurotransmitter transporters, H-coupled neurotransmitter, nutrient and drug transporters, H/Cl exchangers, K+, H+, and Ca++ channels, Cl- channels, crystal structures of channels and transporters, computational molecular dynamics, and mathematical models of transport. Workshops on patch clamp, amperometry, and fluorescent imaging are supplemental. The meeting consists of 3 plenary speakers, 20 lectures, 3 workshops, and 2 poster sessions. A late-invitation speaker is planned for breaking news. All speakers are committed to prepare their lectures for a diverse audience of graduate students, postdoctoral fellows, early career academics, and pharmaceutical researchers. Recruitment will pay attention to women and under-represented groups, and, in keeping with the Erice tradition, there will ample time for informal discussions. Transporters and channels are crucial for many cell functions including synaptic transmission, metabolic and nutrient transport, water and ion homeostasis, and excitability, and the list of diseases linked to transporter and channel mutations is growing. Transporters and channels are different yet they have many common properties; e.g., transporters have channel conformations but little is understood about the significance of these states for human diseases, drug abuse, and possible therapies. This conference includes background sessions and advanced seminars in these two fields so that leading researchers from the channel and transporter fields, as well as younger students and early career scientists, can benefit from cross-fertilization of these important research areas with potential benefit to biomedical research.

说明（由申请人提供）：我们请求支持将于 2008 年 5 月 12 日至 18 日在西西里岛埃里斯举行的第三届国际生物物理学院会议“转运蛋白和通道”。我们还请求于 2011 年举行后续会议。 2008 年会议是 2002 年会议和 NIMH 支持的 2005 年会议的续集。 2008 年的会议计划在 Frances Ashcroft 在伦敦组织的补充会议之前举行。埃里斯会议的学生和演讲者可能会继续前往伦敦。很少有会议专门关注传输者和渠道之间的关系，而是关注很少串扰的传输者或渠道。大量的评论、新的研究和最近召开的像我们这样的会议已经改变了这一局面。然而，年轻的研究人员可能没有意识到对运输者和渠道的全面和比较的看法所提供的职业机会。通道和转运蛋白相关疾病、蛋白质调控、分子动力学和药物发现是交叉研究领域的几个例子。因此，持续需要与两个学科的讲师和参与者举行会议。埃里斯会议以戈登研究会议为蓝本，但重点关注跨学科的早期职业观众，为通道和转运蛋白研究人员之间的互动提供了前所未有的机会，以实现专业接触和机会。转运蛋白和通道对于几乎所有细胞功能都至关重要，包括突触传递、代谢和营养物质运输、水和离子稳态以及兴奋性。与转运蛋白和通道突变相关的疾病清单正在不断增加。转运蛋白也具有产生电流的构象，但人们对转运蛋白中内源通道状态的生理作用或这些通道状态的结构相关性知之甚少。我们建议的系列讲座包括背景会议、研讨会和研讨会。来自离子通道和转运蛋白领域的顶尖研究人员已同意参加，我们将接受来自各个领域的学生，以实现信息交流和交叉受精。该计划将涵盖配体门控和电压门控离子通道、Na耦合神经递质转运蛋白、H耦合神经递质、营养物和药物转运蛋白、H/Cl交换器、K+、H+和Ca++通道、Cl-通道、通道的晶体结构和转运蛋白、计算分子动力学和转运数学模型。关于膜片钳、电流分析法和荧光成像的研讨会是补充。会议由3位主讲嘉宾、20场讲座、3场研讨会和2场海报会议组成。计划晚邀请一位演讲者来发布突发新闻。所有演讲者都致力于为研究生、博士后研究员、早期职业学者和药物研究人员等不同受众准备演讲。招聘将关注女性和代表性不足的群体，并且按照埃里斯的传统，将有充足的时间进行非正式讨论。转运蛋白和通道对于许多细胞功能至关重要，包括突触传递、代谢和营养运输、水和离子稳态以及兴奋性，与转运蛋白和通道突变相关的疾病清单正在不断增加。转运蛋白和通道是不同的，但它们有许多共同的属性；例如，转运蛋白具有通道构象，但人们对这些状态对人类疾病、药物滥用和可能的疗法的重要性了解甚少。本次会议包括这两个领域的背景会议和高级研讨会，以便来自通道和转运蛋白领域的领先研究人员以及年轻学生和早期职业科学家能够从这些重要研究领域的交叉授精中受益，并为生物医学研究带来潜在益处。