Erice School of Biophysics Conference on Channels and Transporters

埃里斯生物物理学院通道和转运蛋白会议

• 批准号: 7608708
• 负责人: LOUIS J DE FELICE
• 金额: --
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-15 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7608708
• 关键词: Area; Attention; Biomedical Research; Biophysics; Cell physiology; Commit; Discipline; Disease; Drug abuse; Educational workshop; Fertilization; Gated Ion Channel; Homeostasis; Image; International; Ion Channel; Ions; Ligands; Link; London; Metabolic; Modeling; Molecular Conformation; Mutation; Neurotransmitters; Nutrient; Participant; Pharmaceutical Preparations; Pharmacologic Substance; Physiological; Postdoctoral Fellow; Property; Proteins; Regulation; Research; Research Personnel; Role; Schools; Scientist; Series; Sicily; Structure; Students; Synaptic Transmission; Time; Water; Woman; career; comparative; drug discovery; graduate student; human disease; lecturer; lectures; mathematical model; meetings; molecular dynamics; news; patch clamp; posters; programs; symposium; voltage

DESCRIPTION (provided by applicant): We request support for the third International School of Biophysics conference on "Transporters and Channels" to be held in Erice, Sicily, 12-18 May 2008. We also request a continuation meeting to be held in 2011. The 2008 meeting is a sequel to the 2002 and NIMH-supported 2005 meetings. The 2008 meeting was planned to occur just before a complementary meeting organized by Frances Ashcroft in London. Students and speakers from the Erice conference may thus continue to London. Few meetings pay exclusive attention to the relationship between transporters and channels, but focus instead on transporters or channels with little crosstalk. Numerous reviews, new research, and recent conferences like ours have changed this landscape. Nevertheless, young researchers may be unaware of career opportunities offered by a comprehensive and comparative view of transporters and channels. Channel- and transporter-related diseases, protein regulation, molecular dynamics, and drug discovery are a few examples of intersecting research areas. Thus, there is a continuing need for a meeting with lecturers and participants from both disciplines. The Erice meeting - which is modeled after Gordon Research Conferences but with emphasis on an interdisciplinary, early career audience - offers unprecedented opportunities for interactions between channel and transporter researchers for professional contacts and opportunities. Transporters and channels are crucial for virtually every cell function, including synaptic transmission, metabolic and nutrient transport, water and ion homeostasis, and excitability. The list of diseases linked to transporter and channel mutations is growing. Transporters also have current-generating conformations, but little is understood about the physiological role of the endogenous channel states in transporters or about the structural correlates of these channel states. The series of lectures we propose includes background sessions, workshops, and seminars. Leading researchers from ion channel and transporter fields have agreed to take part, and we will accept students from all fields with a view toward information exchange and cross-fertilization. The program will cover ligand- and voltage-gated ion channels, Na-coupled neurotransmitter transporters, H-coupled neurotransmitter, nutrient and drug transporters, H/Cl exchangers, K+, H+, and Ca++ channels, Cl- channels, crystal structures of channels and transporters, computational molecular dynamics, and mathematical models of transport. Workshops on patch clamp, amperometry, and fluorescent imaging are supplemental. The meeting consists of 3 plenary speakers, 20 lectures, 3 workshops, and 2 poster sessions. A late-invitation speaker is planned for breaking news. All speakers are committed to prepare their lectures for a diverse audience of graduate students, postdoctoral fellows, early career academics, and pharmaceutical researchers. Recruitment will pay attention to women and under-represented groups, and, in keeping with the Erice tradition, there will ample time for informal discussions. Transporters and channels are crucial for many cell functions including synaptic transmission, metabolic and nutrient transport, water and ion homeostasis, and excitability, and the list of diseases linked to transporter and channel mutations is growing. Transporters and channels are different yet they have many common properties; e.g., transporters have channel conformations but little is understood about the significance of these states for human diseases, drug abuse, and possible therapies. This conference includes background sessions and advanced seminars in these two fields so that leading researchers from the channel and transporter fields, as well as younger students and early career scientists, can benefit from cross-fertilization of these important research areas with potential benefit to biomedical research.

描述（由申请人提供）：我们要求在2008年5月12日至12日在西西里岛的Erice举行的第三届国际生物物理学会议上的第三届国际生物物理学会议。我们还要求在2011年举行一次持续会议。2008年的会议是2002年和NIMH支持的2005年会议的续集。计划在伦敦弗朗西斯·阿什克罗夫特（Frances Ashcroft）举办的补充会议之前举行的2008年会议。因此，来自Erice会议的学生和演讲者可能会继续前往伦敦。很少有会议专注于转运者和渠道之间的关系，而是将重点放在几乎没有串扰的转运者或渠道上。许多评论，新的研究和像我们这样的最新会议都改变了这一景观。然而，年轻的研究人员可能不知道运输商和渠道的全面和比较观点提供的职业机会。通道和转运蛋白相关的疾病，蛋白质调节，分子动力学和药物发现是相交研究领域的一些例子。因此，持续需要与两个学科的讲师和参与者会面。 Erice会议是以Gordon研究会议为基础的，但着重于跨学科的早期职业受众 - 为渠道与运输者研究人员之间的互动提供了前所未有的机会，以提供专业的联系和机会。转运蛋白和通道对于几乎每个细胞功能都至关重要，包括突触传播，代谢和营养转运，水和离子稳态以及兴奋性。与转运蛋白和通道突变有关的疾病清单正在增长。转运蛋白也具有当前产生的构象，但是关于内源性通道状态在转运蛋白或这些通道状态的结构相关的生理作用的了解很少。我们提出的一系列讲座包括背景会议，讲习班和研讨会。来自离子频道和运输者领域的主要研究人员已同意参加，我们将接受来自所有领域的学生，以朝着信息交流和交叉施用。该程序将涵盖配体和电压门控离子通道，NA耦合的神经递质转运蛋白，H耦合神经递质，营养和药物转运蛋白，H/CL交换剂，K+，H+，H+，H+，Ca ++通道，CL-通道，CL-通道，CL-CHANNEL，CL-CHANNEL，CLENEL WANSILEL，CLYSLANES，CLYSEL SUNCELERS，CLYSELES和TRANSTERS COLLASTERS和TRANSSTORATIC MALICERATIC DYMATINATION和MERATOLICTAINTAL的晶体结构。贴片夹，安培法和荧光成像的讲习班是补充的。会议由3位全体演讲者，20个讲座，3次讲习班和2次海报会议组成。计划为突发新闻提供后期发言人。所有演讲者都致力于为多样化的研究生，博士后研究员，早期职业学者和制药研究人员准备讲座。招聘将关注妇女和代表性不足的群体，并且按照Erice的传统，将有足够的时间进行非正式的讨论。转运蛋白和通道对于许多细胞功能至关重要，包括突触传播，代谢和营养运输，水和离子稳态以及兴奋性，以及与转运蛋白和通道突变有关的疾病清单正在增长。转运蛋白和通道不同，但它们具有许多共同的特性。例如，转运蛋白具有通道的构象，但对这些状态对人类疾病，药物滥用和可能的疗法的意义知之甚少。这次会议包括背景会议和这两个领域的高级研讨会，以便从渠道和运输者领域的领先研究人员以及年轻的学生和早期职业科学家可以从这些重要研究领域的跨批准中受益，并具有潜在的生物医学研究受益。