Mechanistic-Based Non-Invasive Assessment of Retinal Damage in HAART Era

HAART时代基于机制的视网膜损伤无创评估

基本信息

批准号：
7430352
负责人：
Dirk-Uwe G Bartsch
金额：
$ 31.92万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-06-01 至 2011-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7430352
关键词：
3-Dimensional Acquired Immunodeficiency Syndrome Affect Anti-HIV Therapy Antiviral Agents Antiviral Therapy Appearance Area Biological Markers Blindness Blood Circulation Blood Vessels Blood capillaries Brain CD4 Lymphocyte Count Canada Cell Death Cells Central Nervous System Diseases Cicatrix Clinical Closure Collaborations Complex Cross-Sectional Studies Cytomegalovirus DNA Data Defect Designer Drugs Development Diabetic Angiopathies Disease Disease Progression Dropout Endothelial Cells Enzymes Etiology Evaluation Extracellular Matrix Fluorescein Angiography Fundus photography Glaucoma Glutamate Receptor Goals Grant HIV HIV Infections Hand Healed Histologic Histology Image Imaging Techniques Individual Infarction Inflammatory Injury Invasive Ischemia Lasers Lesion Life Location Longitudinal Studies Magnetic Resonance Imaging Measurement Measures Mediating Mediator of activation protein Modeling Nature Nerve Fibers Nervous System Trauma Neuraxis Neurons Neuropsychological Tests Neurotransmitters Ophthalmoscopy Optic Disk Optic Nerve Optical Coherence Tomography Organ Patients Perimetry Preparation Prevalence Primary Health Care Principal Investigator Provider Psychophysiology Qualifying Quality of life Reporting Research Research Personnel Resolution Resort Retina Retinal Retinal Defect Retinal Diseases Retinitis Scanning Schedule Serum Severities Site Staging Standards of Weights and Measures Testing Thick Three-Dimensional Image Three-Dimensional Imaging Tissues Valganciclovir Validation Viral Load result Virus Diseases Vision Visual Fields Week Work antiretroviral therapy base capillary cotton wool spots cytokine excitotoxicity ganglion cell healing improved instrument macrophage macula mathematical model murine nodule inducing virus neurobehavioral neuropathology novel optic nerve disorder polarimetry prevent programs relating to nervous system retinal damage retinal ischemia retinal nerve fiber layer white matter

项目摘要

DESCRIPTION (provided by applicant): Patients with HIV-disease have responded well to the highly activated antiretroviral therapy (HAART). However, our research group and others have shown that vision loss continues to occur despite elevated CD4 counts. In this grant we plan to assess and quantify retinal damage to the retinal nerve fiber layer (RNFL) and normal retinal tissue with the help of two non-invasive imaging techniques - scanning laser polarimetry (SLP) and optical coherence tomography (OCT). We will test two different hypotheses that might explain the vision loss - one is cytokine mediated optic neuropathy and the other is microvascular ischemia in the retina. The first specific aim of our study is to quantify RNFL defects by SLP, conventional OCT and high-resolution (HR) OCT in a cross-sectional and longitudinal study. RNFL defects are measured along a circumference around the optic nerve head in a manner analogous to studies in glaucoma research. The second specific aim is to quantify retinal defects throughout the posterior pole by HR-OCT in a cross-sectional and longitudinal study, as well. These retinal defects can occur throughout the retina and will be imaged by 3-D images. The third specific aim is correlate the RNFL and retinal defects detected with both imaging instruments with standard visual field function testing, short-wavelength automated perimetry and other structural and function data. Our research team encompasses a group of highly-qualified individuals with various expertise. Our team includes experts on retinal imaging, an expert in the study of HIV-related ocular complications, an expert in neurobehavioral research, and an expert on high-resolution optical coherence tomography.

描述（由申请人提供）：HIV疾病患者对高度激活的抗逆转录病毒疗法（HAART）的反应很好。但是，我们的研究小组和其他人表明，尽管CD4计数升高，视力丧失仍在继续。在这笔赠款中，我们计划借助两种非侵入性成像技术评估和量化对视网膜神经纤维层（RNFL）和正常视网膜组织的视网膜损伤 - 扫描激光极化（SLP）和光学相干断层扫描（OCT）。我们将检验两个可能解释视力丧失的假设 - 一种是细胞因子介导的视神经病变，另一种是视网膜中的微血管缺血。我们研究的第一个具体目的是在横截面和纵向研究中通过SLP，常规OCT和高分辨率（HR）OCT量化RNFL缺陷。 RNFL缺陷沿着视神经头周围的周长测量，类似于青光眼研究的研究。第二个具体目的是在横截面和纵向研究中通过HR-OCT量化整个后极的视网膜缺陷。这些视网膜缺陷可以在整个视网膜中发生，并将通过3-D图像成像。第三个具体目的是将与标准视野功能测试，短波长度自动化和其他结构和功能数据的Imaging Ingementments检测到的RNFL和视网膜缺陷相关联。我们的研究团队涵盖了一群具有各种专业知识的高度合格的人。我们的团队包括视网膜成像的专家，与HIV相关的眼部并发症研究专家，神经行为研究专家以及高分辨率光学相干断层扫描专家。