Organ Specific Project

器官特定项目

• 批准号: 10530895
• 负责人: Dhruv Singhal
• 金额: $ 125万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10530895
• 关键词: 3-Dimensional; Acquired Immunodeficiency Syndrome; Affect; American; Amyotrophic Lateral Sclerosis; Anatomy; Animal Model; Biological Markers; Blood capillaries; California; Cancer Survivorship; Clinical; Continuance of life; Data; Development; Dietary Fats; Drainage procedure; Early Diagnosis; Foundations; Future; Gender; Goals; Health; Human; Human BioMolecular Atlas Program; Image; Immune response; Indiana; Individual; Institution; Intervention; Israel; Knowledge; Libraries; Liquid substance; Lower Extremity; Lymph; Lymph Node Mapping; Lymphatic; Lymphatic Capillaries; Lymphatic Diseases; Lymphatic System; Lymphedema; Lymphoid Tissue; Magnetic Resonance Imaging; Medical center; Medicine; Molecular; Molecular Profiling; Morphology; Multiple Sclerosis; Muscular Dystrophies; Operative Surgical Procedures; Optics; Organ; Parkinson Disease; Patients; Pennsylvania; Peripheral; Persons; Pharmacology; Physical shape; Prevalence; Process; Prognosis; Sampling; Smooth Muscle Myocytes; Specimen; System; Technology; Therapeutic; Thoracic Duct; Three-Dimensional Imaging; United States; United States National Institutes of Health; Universities; Upper Extremity; Vascular System; Visual; Visualization; absorption; body system; cell type; healthy volunteer; imaging modality; improved; infancy; lymph nodes; lymphatic imaging; lymphatic vessel; molecular marker; prospective; racial and ethnic; radiological imaging; tissue mapping; transcriptome; transcriptomics

Abstract: Lymphatic disease affects over 10 million patients in the United States and are grossly understudied. Lymphedema, the most commonly occurring lymphatic disease, is considered one on of the most significant cancer survivorship issues in the United States. Of significant note, our primary understanding and mapping of the lymphatic system come from animal models. A comprehensive anatomic reference from the human lymphatic system does not currently exist. We propose the development of a lymphatic tissue mapping center (TMC) as a part of the NIH Human Biomolecular Atlas Program (HuBMAP). Specifically, through a consortium of institutions including the Beth Israel Deaconess Medical Center, University of Southern California, University of Pennsylvania, Stanford University, and Indiana University, we will acquire both lymphatic collectors and lymphatic capillaries in healthy individuals across the entire health spectrum and register each of these samples to the associated angiosome thereby allowing coordination with HuBMAP. These samples will undergo spatial transcriptome analysis. Moreover, we will perform 3D radiologic imaging of lymphatic collectors throughout the body. The spatial transcriptome analysis and 3D imaging data will be processed and transferred to the HuBMAP Integration, Visualization, and Engagement (HIVE) Collaborative. The lymphatic tissue mapping center, alongside HuBMAP, will provide fine detail anatomic precision of the lymphatic system better informing future surgical interventions. The spatial transcriptome analysis will provide potential targets for future pharmacologic therapeutics.

抽象的： 淋巴病在美国影响超过1000万患者，并且严重影响 研究了。淋巴水肿是最常见的淋巴病，被认为是一种 美国最重要的癌症生存问题。重要的是，我们的主要理解 淋巴系统的映射来自动物模型。来自 人类淋巴系统目前不存在。我们提出了淋巴组织的发展 映射中心（TMC）作为NIH人类生物分子图书馆计划（Hubmap）的一部分。具体来说， 通过包括贝丝以色列女执事医学中心的机构联盟 南加州，宾夕法尼亚大学，斯坦福大学和印第安纳大学，我们将获得 在整个健康范围内健康个体的淋巴收集器和淋巴毛细血管和 将这些样品中的每一个注册到相关的血管群，从而允许与 hubmap。这些样本将进行空间转录组分析。而且，我们将执行3D 整个体内淋巴收集器的放射学成像。空间转录组分析和3D 成像数据将被处理并转移到Hubmap集成，可视化和参与度 （Hive）协作。淋巴组织映射中心与Hubmap一起提供精美的细节 淋巴系统的解剖学精度可以更好地告知未来的手术干预措施。空间 转录组分析将为未来的药物治疗剂提供潜在的靶标。