Mechanistic-Based Non-Invasive Assessment of Retinal Damage in HAART Era

HAART时代基于机制的视网膜损伤无创评估

• 批准号: 8154961
• 负责人: Dirk-Uwe G Bartsch
• 金额: $ 57.42万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8154961
• 关键词: 3-Dimensional; Algorithms; Appearance; Back; Biological Assay; Blindness; CD4 Lymphocyte Count; Characteristics; Clinic; Collection; Computational algorithm; Data; Data Set; Databases; Defect; Detection; Development; Dimensions; Disease; Drusen; Engineering; Exhibits; Eye; Goals; Grant; HIV; HIV Infections; HIV Seropositivity; Healed; Image; Laboratories; Lasers; Maps; Measures; Methods; Nervous System Trauma; Neuraxis; Neurologic; Neuropsychological Tests; Noise; Ophthalmoscopes; Optics; Patients; Phase; Process; Reporting; Research; Resolution; Retinal; Retinal Defect; Scanning; Signal Transduction; Testing; Thick; Tomogram; Vision; Work; adaptive optics; antiretroviral therapy; base; cotton wool spots; data acquisition; digital imaging; healing; improved; neurobehavioral; physical science; research study; retinal damage; statistics

DESCRIPTION (provided by applicant): Patients with HIV-disease continue to be treated with highly activated antiretroviral therapy (HAART). However, our research group and others have shown that vision loss and neurological loss continues to occur despite elevated CD4 counts. We have previously shown that we are able to visualize subtle retinal changes associated with healed cotton-wool spots (CWS) up to 16 years after the active phase. In this grant we plan to study the group of subjects that continue to exhibit neurological changes and retinal damage. Our hypothesis is that retinal damage is associated with neurological changes. Our first specific aim is to quantify retinal damage by high-resolution adaptive- optical corrected OCT. Our second specific aim is to develop a computer algorithm to map the defects associated with healed CWS. Our results have indicated that healed CWS demonstrate a characteristic restructuring of the retinal layers. This restructuring can be mapped in 3-D OCT images. The third specific aim is to correlate structural retinal defects with neurological markers collected by our collaborators at the UCSD's HIV Neurobehavioral Research Center. A possible correlation might help us by using retinal structural markers as indicators for neurological damage. Our team of collaborators includes experts on retinal imaging, computer processing, and neurobehavioral research. PUBLIC HEALTH RELEVANCE: This grant will create a method of automatically mapping the presence of retinal damage associated with HIV infection. A high-resolution eye camera will be used to systematically image the back of the eye. The study will compare structural information to functional information to find a possible correlation.

描述（由申请人提供）：HIV疾病患者继续接受高度活化的抗逆转录病毒疗法（HAART）治疗。但是，我们的研究小组和其他人表明，尽管CD4计数升高，视力丧失和神经系统丧失仍在继续。我们以前已经表明，我们能够可视化与活动相后16年的愈合棉毛斑点（CW）相关的微妙的视网膜变化。在这笔赠款中，我们计划研究继续表现出神经系统变化和视网膜损害的受试者组。我们的假设是视网膜损伤与神经系统变化有关。我们的第一个具体目的是通过高分辨率自适应光学校正OCT来量化视网膜损伤。我们的第二个具体目的是开发计算机算法以绘制与治愈CW相关的缺陷。我们的结果表明，治愈的CWS证明了视网膜层的特征重组。该重组可以在3-D OCT图像中映射。第三个具体目的是将结构性视网膜缺陷与我们在UCSD的HIV HIV神经行为研究中心收集的神经系统标记相关联。可能的相关性可能会通过使用视网膜结构标记作为神经系统损害的指标来帮助我们。我们的合作者团队包括视网膜成像，计算机处理和神经行为研究的专家。 公共卫生相关性：该赠款将创建一种自动映射与HIV感染相关的视网膜损害的方法。高分辨率的眼镜摄像头将用于系统地对眼睛的背面形象。该研究将将结构信息与功能信息进行比较，以找到可能的相关性。