MAPPING INTERACTIVE CANCER SUSCEPTIBILITY GENES IN PROSTATE CANCER

绘制前列腺癌中相互作用的癌症易感基因图谱

• 批准号: 7716644
• 负责人: THEODORE G KRONTIRIS
• 金额: $ 0.12万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-20 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716644
• 关键词: Alleles; Biological Factors; Blood; Brothers; Cancer-Predisposing Gene; Candidate Disease Gene; Computer Retrieval of Information on Scientific Projects Database; Development; Disease; Funding; Genes; Genetic; Genetic Epistasis; Genetic Risk; Grant; Human Genome; Inherited; Institution; Laboratory Study; Malignant Neoplasms; Malignant neoplasm of prostate; Maps; Patients; Purpose; Research; Research Personnel; Resources; Risk; Role; Source; Structure; Testing; United States National Institutes of Health; Variant; anticancer research; cancer risk; genetic risk factor; research study; statistics

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research study is to collect blood from pairs of brothers with prostate cancer in order to do laboratory studies. These laboratory studies will look for genes (factors that can be inherited) that might influence the risk of prostate cancer. Cancer researchers have recently identified several biological factors that may be important in the development of prostate cancer. Researchers will determine the role of more than two dozen genetic factors in cancer research. We will also specifically study whether there is any relationship between any of these genetic factors and the risk of developing prostate cancer. Cancer researchers have come to appreciate that the risk of getting cancer may be increased because of inherited genes. Sometimes the risk can be very strong; sometimes the risk is relatively weak. We are studying whether many genes with weak contributions to cancer risk can interact to produce a strong risk. The purpose of this study is to gather allele-sharing statistics at approximately 25 candidate loci throughout the human genome most likely to influence genetic risk of prostate cancer, to perform fine structure multipoint analysis for candidate genes/regions showing suggestive evidence for linkage, to perform a marker-guided strategy for testing gene x gene interactions in disease and to identify disease variants within candidate genes in appropriate patient subsets.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 这项研究的目的是收集患有前列腺癌的兄弟的血液，以便进行实验室研究。这些实验室研究将寻找可能影响前列腺癌风险的基因（可遗传的因素）。 癌症研究人员最近发现了几种可能在前列腺癌发生过程中起重要作用的生物因素。 研究人员将确定二十多个遗传因素在癌症研究中的作用。我们还将专门研究这些遗传因素与患前列腺癌的风险之间是否存在任何关系。癌症研究人员已经认识到，遗传基因可能会增加患癌症的风险。有时风险可能非常大；有时风险相对较弱。我们正在研究许多对癌症风险影响较弱的基因是否可以相互作用产生很强的风险。 本研究的目的是收集整个人类基因组中最有可能影响前列腺癌遗传风险的大约 25 个候选基因座的等位基因共享统计数据，对显示连锁证据的候选基因/区域进行精细结构多点分析，以执行一种标记引导策略，用于测试疾病中的基因 x 基因相互作用，并识别适当患者子集中候选基因内的疾病变异。