A Personal Sampler for Assessing Inhaled Nanoparticle Exposures

用于评估吸入纳米颗粒暴露的个人采样器

• 批准号: 7449478
• 负责人: John Volckens
• 金额: $ 7.15万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7449478
• 关键词: Personal; Sampler; Assessing; Inhaled; Nanoparticle

DESCRIPTION (provided by applicant): Elucidation of potential nanoparticle exposure-disease relationships requires the development of an adequate exposure assessment method, as exposure assessment provides key input into subsequent epidemiologic and toxicological investigation. The absence of a personal exposure assessment method for nanoparticle aerosols prevents progress towards understanding potential nanoparticle exposure-disease relationships. The goal of this work is to develop an accurate, sensitive, and specific method to assess personal exposures to engineered nanoparticles. The method will assess the inhalation route of exposure, and hence, the measurement of nanoparticle concentrations in air. To quantify concentrations of airborne nanoparticles, a measurement must be able to segregate the aerosol by size (to capture only particles smaller than 100 nm) and count these particles following size-segregation. Also, because inhaled nanoparticles enter strictly through the oral/nasal route, the method should be oriented to measure breathing zone concentrations within the vicinity of the upper torso. Finally, and perhaps most importantly, the method must be able to distinguish engineered nanoparticles from other incidental nanoparticles (i.e., ultrafine particles) that are ubiquitous in workplace and ambient air. Relevance Successful completion of this research will establish a method to estimate human exposures to engineered nanoparticles in workplace environments. Such a method is critical to the establishment of nanoparticle dose- response relationships, as current methods lack both specificity and sensitivity. Results from this research can also be translated to the larger realm of health-related air pollution outside of the workplace (e.g., indoor air, ambient air pollution), both nationally and internationally.

描述（由申请人提供）：阐明潜在的纳米颗粒暴露 - 疾病关系需要发展适当的暴露评估方法，因为暴露评估提供了对随后的流行病学和毒理学研究的关键输入。没有针对纳米颗粒气溶胶的个人暴露评估方法阻止了了解潜在的纳米颗粒暴露 - 疾病关系。这项工作的目的是开发一种准确，敏感和特定的方法来评估对工程纳米颗粒的个人暴露。该方法将评估接触的吸入途径，因此，测量空气中的纳米颗粒浓度。为了量化机载纳米颗粒的浓度，测量必须能够按大小分离气溶胶（仅捕获小于100 nm的颗粒），并在尺寸分离后计数这些颗粒。同样，由于吸入的纳米颗粒严格通过口服/鼻腔途径进入，因此应将该方法定向以测量上部躯干附近呼吸区浓度。最后，也许最重要的是，该方法必须能够将工程的纳米颗粒与其他在工作场所和环境空气中无处不在的偶然纳米颗粒（即超铁颗粒）区分开。这项研究的成功完成将建立一种方法，以估计人类在工作场所环境中对工程纳米颗粒的暴露。这种方法对于建立纳米粒子剂量响应关系至关重要，因为当前方法既缺乏特异性和灵敏度。这项研究的结果也可以转化为工作场所以外（例如，室内空气，环境空气污染）在国家和国际上的更大的空气污染领域。