Lung Deposition Sampler for Inhalable Aerosol

吸入气溶胶肺沉积采样器

• 批准号: 7294810
• 负责人: John Volckens
• 金额: $ 6.45万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7294810
• 关键词: Lung; Deposition; Sampler; Inhalable; Aerosol

DESCRIPTION (provided by applicant): The goal of this research is to develop a more powerful exposure assessment tool that directly measures the deposition of inhaled particles within the human lung. Inhaled particles do not always deposit in the lung. Therefore, a device that estimates the size-specific deposition of inhaled particles in the human lung will improve the power of risk assessment by providing a more physiologically-relevant measure of dose, and hence, inhalation hazard in the workplace. This research will build on a wide-body of existing literature on aerosol inhalation and lung deposition. By integrating this technology into an existing inhalable sampling cassette, (i.e., the IOM sampling cassette) we will be able to reproduce both aerosol inhalability and deposition, allowing for more realistic and reliable hazard assessment. Such integration will aid industry acceptance of our device, being both inexpensive and requiring no purchase of additional sampling technologies. Additionally, the use of a previously validated housing precludes the need for costly aspiration efficiency tests typically associated with aerosol sampler development. The significance of the proposed research is the establishment a more physiologically relevant metric of inhaled aerosol dose. A measurement more closely related to dose will increase our ability to associate the onset of occupational respiratory diseases with specific exposures, which, in turn, will allow for more efficient intervention and control strategies targeted to reduce specific toxic components of workplace atmospheres. Enhancing the predictive power of occupational epidemiology and risk assessment will help regulating agencies better prioritize the long list of existing and emerging aerosol hazards and allow them to establish targeted, health-based exposure standards. Results from this research can also be translated to the larger realm of health-related air pollution outside of the workplace (e.g., indoor air, ambient air pollution), both nationally and internationally in developing countries.

描述（由申请人提供）：这项研究的目的是开发一种更强大的暴露评估工具，该工具直接测量人类肺中吸入颗粒的沉积。吸入颗粒并不总是沉积在肺中。因此，一种估计人肺中吸入颗粒的大小特异性沉积的设备将通过提供更相关的剂量量度，从而提高风险评估的能力，从而在工作场所中的吸入危险。这项研究将基于有关气溶胶吸入和肺部沉积的广泛文献的基础。通过将该技术集成到现有的吸入采样盒中（即IOM采样盒），我们将能够重现气溶胶吸入性和沉积，从而可以进行更现实和可靠的危险评估。这种整合将有助于行业接受我们的设备，既便宜又不需要购买其他采样技术。此外，使用先前验证的外壳的使用排除了通常与气溶胶采样器开发相关的昂贵抽吸效率测试的需求。拟议的研究的意义在于吸入气溶胶剂量的生理上相关的度量标准。与剂量更紧密相关的测量方法将提高我们将职业呼吸道疾病发作与特定暴露的能力相关联，这反过来又可以实现更有效的干预和控制策略，以减少工作场所气氛的特定有毒成分。增强职业流行病学和风险评估的预测能力将有助于调节机构更好地优先考虑现有和新兴气溶胶危害的长期清单，并允许它们建立有针对性的，基于健康的敞口标准。这项研究的结果也可以转化为在工作场所以外（例如，室内空气，环境空气污染）在国家和国际发展中国家，在发展中国家之外的健康相关空气污染领域。