Fetal Exposure to Environmental Toxicants and Child Outcome

胎儿接触环境毒物和儿童结局

基本信息

批准号：
7458238
负责人：
Enrique Mapua Ostrea
金额：
$ 57.88万
依托单位：
WAYNE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-04-01 至 2013-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7458238
关键词：
Address Adolescence Adverse effects Affect Age Age-Years Alcohols Andro-Diane Animals Area Attention Behavior Behavioral Biological Markers Birth Blood Brain Carbamates Caregivers Chemicals Child Child Development Childhood Class Cognition Cohort Studies Collaborations Condition Data Data Analyses Detection Developed Countries Developing Countries Development Discipline Doctor of Medicine Doctor of Philosophy Drug usage Environment Etiology Evaluation Evolution Exhibits Exposure to Family Study Filipino Funding Goals Growth Hair Health Sciences High Prevalence Home environment House Dust Household Human Illicit Drugs Infant Insecticides Institution Intelligence Interdisciplinary Study International Laboratories Lead Learning Letters Life Long-Term Effects Longitudinal Studies Mass Fragmentography Measurement Measures Meconium Memory Mercury Methods Michigan Monitor Motor Skills Neurodevelopmental Deficit Neurodevelopmental Problem Neurotoxins Newborn Infant Numbers Nursery Schools Oregon Outcome Outcome Measure Outcome Study Parents Participant Performance Perinatal Exposure Pesticides Philippines Population Study Positioning Attribute Pregnancy Pregnant Women Prevalence Prevention intervention Propoxur Psychologist Psychopathology Public Health Range Rate Recording of previous events Research Research Personnel Sample Size Sampling School-Age Population Score Secondary to Site Social support Socioeconomic Status Staging System Testing Toxic Environmental Substances Toxic effect Umbilical Cord Blood United States United States National Institutes of Health Universities University Hospitals Violence Virginia Xenobiotics bioallethrin carbamate insecticide cohort critical developmental period cyfluthrin cypermethrin design drug testing early childhood executive function experience follow-up human study in utero innovation insight interest member mental development method development neurobehavioral neurobehavioral test neurodevelopment neurotoxic pesticide exposure postnatal prenatal prenatal exposure pyrethroid self help skills success tool

项目摘要

DESCRIPTION (provided by applicant): There is widespread use and exposure of pregnant women and their infants to pesticides but limited data is available on the long term effects of these neurotoxicants on the growth and neurodevelopment of the children. We propose to continue the longitudinal study (up to age 6 years) of our cohort (N=754) of infants, a high percentage of whom were antenatally exposed to propoxur, bioallethrin, cyfluthrin and cypermethrin (heretofore referred to as pesticides). We have tested these infants up to 2 years of age using the Fagan Test of Infant Intelligence and Griffiths' Mental Development Scales. At 2 years, neurobehavioral testing revealed a significant decrease in Griffiths performance in association with prenatal exposure of the infants, particularly to propoxur. We intend to study the progress of these deficits and to uncover any delayed neurotoxic effects of pesticide exposure in these children. AIMS: (1) To examine the relationship between antenatal exposure to pesticides and neurobehavioral development of children at 4 and 6 years of age, (2) To examine the relationship between postnatal exposure to pesticides, as measured by analysis of house dust and children's hair, and neurobehavioral development of children at 4 and 6 years, and (3) To examine the relationship between prenatal and postnatal exposure to pesticides and neurobehavioral development at 4 and 6 years. We hypothesize that there will be more neurodevelopmental deficits associated with prenatal or postnatal exposure to pesticides compared to the unexposed group and the deficits will be more pronounced with both pre- and postnatal exposures. METHODS: At 4 and 6 years of age, hair from children in our ongoing study cohort, as well as house dust from their homes, will be collected and analyzed for pesticides by gas chromatography/ mass spectrometry to detect ongoing exposure. The children will be tested at 4 and 6 years with a battery of tests which assess: (1) General cognition, (2) Attention & executive function, (3) Memory, (4) Behavior and (5) Self help. These tests explore the domains and functions of the brain that are affected by pesticides in animal and human studies. DATA ANALYSIS: The outcome measures from these tests will be correlated, after adjustment for confounders, to pre- and/or postnatal exposure to pesticides. PUBLIC HEALTH RELEVANCE: This study utilizes a large cohort of infants for whom we have data on prenatal and early childhood pesticide exposure, as well as assessments of growth and neurodevelopment from birth up to 2 years of age, with a 95% follow up rate. The study is important and relevant to public health since it will provide important and much needed information on the longitudinal, adverse effects on the growth and neurodevelopment of children of carbamates and pyrethroids, which are now widely used. The study is important and relevant to public health since it will provide important and much needed information on the longitudinal, adverse effects on the growth and neurodevelopment of children of carbamates and pyrethroids, which are now widely used.

描述（由申请人提供）：孕妇及其婴儿广泛使用和暴露于农药中，但这些神经毒性对儿童的生长和神经发育的长期影响有限。我们建议继续对我们的队列（n = 754）进行纵向研究（长达6岁）的婴儿，其中很大一部分是在产前暴露于丙氧基，生物塞瑞氏蛋白，cyfluthrin和cypermethrin（源自称为橄榄球）的。我们已经使用Fagan的婴儿智力和格里菲斯的心理发展量表对这些婴儿进行了测试，该婴儿最高2岁。在2年的时间里，神经行为测试表明，与婴儿的产前暴露，特别是对丙氧基术的产前暴露，格里菲斯的表现显着下降。我们打算研究这些缺陷的进展，并发现这些儿童中农药暴露的任何延迟的神经毒性作用。目的：（1）检查4至6岁时儿童产前暴露于农药和神经行为之间的关系，（2）检查出生后暴露于农药之间的关系，通过分析房屋粉尘和儿童头发的分析，以及在4和6岁之间的儿童和（3）的关系，以及（3）的关系，以及（3），以及（3），以及（3）的关系。 4到6年的神经行为发展。我们假设与未暴露的组相比，与产前或产后暴露与农药相比，会有更多的神经发育缺陷，而在产前和产后暴露会更明显。方法：在4岁和6岁的时候，我们正在进行的研究队列中的儿童以及他们家中的房屋灰尘将通过气相色谱/质谱法对农药进行分析，以检测正在进行的暴露。儿童将在4年和6年的测试中进行一系列测试，以评估：（1）一般认知，（2）注意力和执行功能，（3）记忆，（4）行为和（5）自助。这些测试探讨了在动物和人类研究中受农药影响的大脑的域和功能。数据分析：调整了混杂因素后，这些测试的结果度量将与产前和/或产后接触农药相关。公共卫生相关性：这项研究利用了大量的婴儿，我们为他们提供了有关产前和幼儿农药暴露的数据，以及对从出生到2岁的生长和神经发育的评估，随访95％。这项研究与公共卫生很重要，并且与公共卫生有关，因为它将提供有关龙骨和拟除虫菊酯儿童的生长和神经发育的纵向，不利影响的重要信息，这些信息现在已被广泛使用。这项研究与公共卫生很重要，并且与公共卫生有关，因为它将提供有关龙骨和拟除虫菊酯儿童的生长和神经发育的纵向，不利影响的重要信息，这些信息现在已被广泛使用。