Fetal exposure to environmental toxins & infant outcome

胎儿接触环境毒素

• 批准号: 7028942
• 负责人: Enrique Mapua Ostrea
• 金额: $ 53.98万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7028942
• 关键词: atomic absorption spectrometry; behavior test; biomarker; blood chemistry; child physical development; child psychology; clinical chemistry; clinical research; cord blood; embryo /fetus toxicology; environmental exposure; environmental toxicology; feces; feces analysis; gas chromatography mass spectrometry; hair; human pregnant subject; infant human (0-1 year); metal poisoning; newborn human (0-6 weeks); pesticide biological effect; pesticide residues; preschool child (1-5); atomic absorption spectrometry; behavior test; biomarker; blood chemistry; child physical development; child psychology; clinical chemistry; clinical research; cord blood; embryo /fetus toxicology; environmental exposure; environmental toxicology; feces; feces analysis; gas chromatography mass spectrometry; hair; human pregnant subject; infant human (0-1 year); metal poisoning; newborn human (0-6 weeks); pesticide biological effect; pesticide residues; preschool child (1-5)

DESCRIPTION (provided by applicant): The exposure of pregnant women to environmental toxins is of major concern because of their potential harm on the fetus. However, the detection of fetal exposure to environmental toxins still remains a major challenge. We propose that meconium analysis is a promising tool to meet this challenge. Aims: (1) To compare the prevalence and amount of fetal exposure to environmental toxins through the analysis of meconium, cord blood and neonatal hair and to determine the degree of agreement among these three methods, (2) to determine the relationship between the prevalence and amount of maternal exposure to environmental toxins during pregnancy, as determined by serial analyses of maternal hair and blood, to the prevalence and amount of fetal exposure to environmental toxins as determined by meconium, cord blood and neonatal hair analyses, and (3) to compare adverse immediate (birth weight, length, head circumference, gestational age) and long term (postnatal growth and neurobehavioral development up to 2 yrs from enrollment) outcomes that are associated with antenatal exposure to environmental toxins as determined by maternal blood, maternal hair, meconium, cord blood and neonatal hair analyses. Study design: Pregnant women (n=750) will be recruited, at midgestation, from the Outpatient Clinic of the Bulacan Provincial Hospital, Philippines and their blood and hair will be obtained at the time of recruitment and at delivery. Umbilical cord blood, meconium and neonatal hair will also be obtained. The samples will be analyzed, by atomic absorption spectrometry, for lead, mercury and cadmium and by gas chromatography/mass spectrometry for the following pesticides and their metabolites: propoxur, transfluthrin, Malathion, DDT, chlorpyrifos, bioallethrin, pretilachlor, lindane, cyfluthrin and cypermethrin. Pertinent maternal and infant data will be obtained after birth. The infants will be subsequently followed up at scheduled intervals for 2 years, to study their physical growth and neurobehavioral development using a battery of tests. Data analysis: The relationship between the presence/amount of environmental toxins in meconium, maternal blood, maternal hair, cord blood or neonatal hair to the immediate and two year outcome in the infants will be studied, while controlling for potential confounders. The presence/amount of environmental toxins in maternal blood, hair, cord blood, meconium and neonatal hair will be also evaluated to determine which substrate (s) provide(s) the best index of exposure for a given toxin. Expected benefits: Meconium analysis may provide a powerful tool to study the prevalence and degree of fetal exposure to environmental toxins and its associated adverse effects. This project can also serve as a model for the study of environmental pollutant problems during pregnancy at a local, national or global level.

描述（由申请人提供）：孕妇暴露于 环境毒素是主要关注的，因为它们对 胎儿。但是，仍发现胎儿暴露于环境毒素 仍然是一个重大挑战。我们建议胎粪分析是一个有前途的 应对这一挑战的工具。目的：（1）比较 通过分析胎儿，脐带，胎儿暴露于环境毒素 血液和新生儿的头发，并确定其中的一致性程度 三种方法，（2）确定患病率和 怀孕期间母亲暴露于环境毒素的量 通过孕产妇的头发和血液的序列分析，以达到患病率和 胎粪确定的胎儿暴露于环境毒素， 脐带血和新生头发分析，（3）比较不良立即 （出生体重，长度，头围，胎龄）和长期 （产后生长和神经行为发育高达2年） 与产前暴露于环境毒素相关的结果 由母亲的血液，孕妇，胎粪，脐带血和新生儿确定 头发分析。研究设计：将招募孕妇（n = 750） 中间寄宿，从Bulacan省医院的门诊诊所， 菲律宾及其血液和头发将在 招聘和交货时。脐带血，胎粪和新生儿头发 也将获得。将通过原子吸收来分析样品 光谱法，用于铅，汞和镉以及气相色谱/质量 用于以下农药及其代谢物的光谱法：丙氧基， Truthrin，Malathion，DDT，Chlorpyrifos，Bioallethrin，Petililachlor， Lindane，Cyfluthrin和Cypermethrin。相关的母亲和婴儿数据将 出生后获得。婴儿随后将在 计划间隔2年，研究其身体成长和 使用一系列测试的神经行为开发。数据分析： 胎粪中环境毒素的存在/数量之间的关系， 母亲的血液，母亲的头发，脐带血或新生儿头发直接 将研究婴儿的两年结局，同时控制 潜在的混杂因素。母体中环境毒素的存在/数量 血液，头发，脐带血，胎粪和新生儿头发也将评估为 确定哪种底物为给定提供了最佳的暴露指数 毒素。预期的好处：胎粪分析可以为 研究胎儿暴露于环境毒素和 它相关的不利影响。该项目还可以作为模型 在当地，国家怀孕期间怀孕期间对环境污染物问题的研究 或全球水平。