Clinical System for Arterial Characterization

动脉表征临床系统

• 批准号: 7117186
• 负责人: STEPHEN FREDERICK FULGHUM
• 金额: $ 36.62万
• 依托单位: NEWTON LABORATORIES
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7117186
• 关键词: angiography; atherosclerotic plaque; bioengineering /biomedical engineering; biomedical equipment development; cardiovascular disorder diagnosis; cardiovascular imaging /visualization; clinical biomedical equipment; clinical research; colorimetry; diagnosis quality /standard; fiber optics; fluorescence spectrometry; human subject; peripheral blood vessel; reflection spectrometry; venous thrombosis; videotape /videodisc

DESCRIPTION (provided by applicant): Published studies indicate that visible wavelength reflectance and fluorescence spectroscopy are each promising techniques for clinically recognizing vulnerable plaque (VP) - a condition prone to rupture and produce arterial thrombosis. Reflectance is already visually accessible in normal angioscopy, and yellow lipid may be seen diffusely through an otherwise white fibrous cap, depending on its thickness, and form a qualitative indication for VP. Progress toward a clinically useful instrument for recognizing VP by quantified spectroscopy requires an arterial, optical-fiber based side-looking probe (SLP). It is a primary goal of the Phase-2 program to accomplish this by building on the Phase-1 tissue-probe-spectroscopy modeling, probe construction techniques developed, and probe - tissue measurements obtained. In the Phase-2 program three SLP designs will be produced and clinically tested in peripheral arteries. The data will be reduced to provide spectrally resolved diffuse reflectance and intrinsic fluorescence. Comparison will be made to results from concurrent Monte Carlo modeling, results from pathology, and results from the measurements of others with respect to characterizing the tissue and recognizing lesions with thin fibrous caps with a significant lipid core - hallmarks of VP. We expect that bringing together the colorimetry information with intrinsic fluorescence will produce results better than either alone.

描述（由申请人提供）：已发表的研究表明，可见波长反射率和荧光光谱法都是临床识别易损斑块（VP）的有前景的技术，易损斑块是一种容易破裂并产生动脉血栓的疾病。在正常血管镜检查中，反射率已经可以通过肉眼观察到，并且根据其厚度，可以通过其他白色纤维帽弥漫地看到黄色脂质，并形成 VP 的定性指示。通过量化光谱识别 VP 的临床有用仪器的进展需要基于动脉光纤的侧视探头 (SLP)。第二阶段计划的主要目标是通过建立第一阶段的组织探针光谱模型、开发的探针构建技术以及获得的探针组织测量来实现这一目标。在第二阶段计划中，将生产三种 SLP 设计并在外周动脉中进行临床测试。数据将被减少以提供光谱分辨的漫反射率和内在荧光。将与并发蒙特卡罗建模的结果、病理学结果以及其他测量结果进行比较，以表征组织和识别具有显着脂质核心（VP 标志）的薄纤维帽病变。我们期望将比色信息与内在荧光结合起来会产生比单独使用任何一种更好的结果。