CONNECTIONS OF LIMBIC SYSTEM & HYPOTHALAMUS

边缘系统的连接

• 批准号: 7369371
• 负责人: LARRY W SWANSON
• 金额: $ 1.02万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7369371
• 关键词: CONNECTIONS; LIMBIC; SYSTEM; HYPOTHALAMUS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The hypothalamus and limbic system are widely thought to provide the neural substrates for motivation and emotion, although the organization of its connections, and indeed the definition of what structures should even be included within the limbic system, is poorly understood and controversial. The long range goal of our work on this topic, which is now in its twentieth year of funding, is to determine with neuroanatomical methods (combined pathway tracing and histochemistry for neurotransmission-related molecules) the precise topographical organization of pathways that interconnect the various nuclei of the hypothalamus, of pathways that innervate the hypothalamus from medial regions of the telencephalon (such as the amygdala and hippocampus), and of pathways that descend from the hypothalamus to brainstem and spinal cord to initiate various classes of instinctive, goal-oriented behavior (e.g., ingestive, reproductive, and defensive).

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。人们普遍认为下丘脑和边缘系统为动机和情感提供神经基质，尽管人们对其连接的组织以及边缘系统中应包含哪些结构的定义知之甚少且存在争议。我们在这一主题上的工作目前已进入资助的第二十个年头，其长期目标是通过神经解剖学方法（神经传递相关分子的路径追踪和组织化学相结合）确定互连各个细胞核的路径的精确拓扑组织。下丘脑的通路、从端脑内侧区域（例如杏仁核和海马体）支配下丘脑的通路以及从下丘脑下降到脑干和脊髓，启动各种本能的、以目标为导向的行为（例如，摄取、生殖和防御）。