Laser Activated Ophthalmic Adhesive
激光激活眼科粘合剂
基本信息
- 批准号:7352743
- 负责人:
- 金额:$ 36.52万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2005
- 资助国家:美国
- 起止时间:2005-04-01 至 2010-10-31
- 项目状态:已结题
- 来源:
- 关键词:AdhesionsAdhesivesAnastomosis - actionAnimal ExperimentsAnimal ModelAnimalsAreaBiocompatible MaterialsBiodegradationBiologicalBlindnessBlood VesselsBlunt TraumaBullaCataractCataract ExtractionChemistryClinicalClinical TrialsClosureCollagenConjunctival PterygiumCorneaCorneal InjuryCorneal UlcerCross-Linking ReagentsCyanoacrylatesDataDevelopmentDoctor of PhilosophyDrug FormulationsEnd PointEnsureExcisionExtracapsularEyeEye diseasesFilmFoundationsFundingGlaucomaGluesGoalsGrantHandHumanImpairmentIn SituIn VitroInstitutesInvestigationKeratitisKeratoplastyLaboratory ResearchLacerationLamellar KeratoplastyLaser In Situ KeratomileusisLasersLeadMeasuresMechanicsMedical ElectronicsMembraneMethodsModelingNational Eye InstituteObject AttachmentOperative Surgical ProceduresOutcomePatientsPenetrating KeratoplastyPhasePhase I Clinical TrialsPhase II Clinical TrialsPhysiologic Intraocular PressurePostoperative PeriodPreparationPrincipal InvestigatorProceduresProcessPropertyProteinsPsychological reinforcementRadial KeratotomyRateReactionReagentResearchResearch PersonnelRetinalRiskRuptureSamplingSecureSiteSmall Business Funding MechanismsSmall Business Innovation Research GrantSolutionsStandards of Weights and MeasuresSterilitySterilization for infection controlStrabismusSurgical FlapsSurgical ModelsSurgical incisionsSurgical suturesSurvivorsSystemTechniquesTechnologyTemperatureTensile StrengthTestingThickTimeTissue AdhesivesTissuesTraumaUnited States Dept. of Health and Human ServicesUnited States Food and Drug AdministrationUnited States National Institutes of HealthVisionVisual DiscomfortWeldingWorkanterior chamberarticular cartilagebasebiomaterial compatibilitycell injurycommercializationconjunctivacorneal surgerydesignexperienceimprovedin vitro Modelin vivoinnovationpre-clinicalpressureprotein crosslinkreconstructionrepairedresearch studyresponsesealsensorskillstissue glueingtissue solderingtissue weldingwound
项目摘要
DESCRIPTION (provided by applicant): The significance of this project is the development of a laser assisted tissue welding technique to close corneal wounds, provide a foundation for innovative treatment of eye disease and demonstrate the unique properties of a laser cured collagen adhesive to repair ophthalmic tissue with superior strength and stability. Millions of ophthalmic procedures are performed annually, most incorporating sutures to close and seal wounds. Yet this method can cause severe complications, can weaken the integrity of the eye and may pose a risk for ocular rupture in the case of blunt trauma. Other techniques to close wounds, including the use of tissue glues or grafting, can be even more problematic. Phase I studies were conducted to measure the biostability of solder formulations, evaluate tissue bonding strategies and compare wound stability as a function of intrachamber pressure in four in vitro models of clinical corneal surgery: radial keratotomy, LASIK flaps, penetrating keratoplasty and cataract excision. The results confirmed that the laser solder approach is superior to standard sutures with no evidence of tissue shrinkage. The strength of the soldered repair was dependent upon reaching a precise temperature set by choice of laser, solder composition and film thickness. Solder biostability is increased by reaction with a standard cross linking reagent. The specific aim for Phase II is to optimize solder processing, laser techniques and surgical outcome in survivor animal surgical models. Task descriptions include preparation of sterile solder under stringent process controls, design and assembly of a compact preclinical laser systems, optimization of a laser hand piece and perform ex vivo and in vivo experiments on a lapine model. Surgical endpoints will include the quality of the wound seal, the extent, if any, of collateral thermal tissue damage, solder stability and biocompatibility. The current methods for closing ocular incisions, similar to other body tissue, require placing sutures to bring tissue edges in apposition. The presence of sutures in the cornea leads to patient discomfort, visual distortions, risk for bacterial proliferation and keratitis. The use of a biological tissue adhesive, with sufficient sealing properties to resist sudden changes in intraocular pressure for a prolonged time, may be of great benefit for the synthesis of corneal wounds, caused either by trauma or induced by surgery.
描述(由申请人提供):该项目的重要性是开发激光辅助组织焊接技术以关闭角膜伤口,为眼部疾病的创新治疗提供了基础,并证明了激光固化的胶原蛋白粘合剂的独特特性,可修复眼科眼科。具有优势强度和稳定性的组织。每年进行数百万个眼科手术,大多数缝合缝合线以关闭和密封伤口。然而,这种方法会引起严重的并发症,可以削弱眼睛的完整性,并可能在钝性创伤的情况下构成眼部破裂的风险。闭合伤口的其他技术,包括使用组织胶或嫁接,可能会更有问题。进行了I期研究以测量焊料制剂的生物稳定性,评估组织键合策略并比较伤口稳定性与四种体外临床角膜手术模型中的伤口稳定性:径向角膜切开术,lasik瓣,穿透性角膜造成术和性切除术。结果证实,激光焊料方法优于标准缝合线,没有组织收缩的证据。焊接维修的强度取决于通过选择激光,焊料组成和膜厚度达到精确的温度。通过与标准的交叉连接试剂反应提高焊料生物稳定性。 II期的具体目的是优化幸存者动物外科手术模型中的焊料加工,激光技术和手术结果。任务描述包括在严格的过程控件下制备无菌焊料,紧凑的临床前激光系统的设计和组装,优化激光手工片并在Likine模型上执行离体和体内实验。手术终点将包括伤口密封的质量,即侧外热组织损伤,焊料稳定性和生物相容性的程度(如果有)。与其他身体组织相似的当前关闭眼切口的方法需要放置缝合线以将组织边缘带入置换。角膜中缝合线的存在导致患者不适,视觉扭曲,细菌增殖的风险和角膜炎。生物组织粘合剂的使用具有足够的密封特性,可抵抗长时间的眼内压力变化,对于由创伤或手术引起的角膜伤口的合成可能有很大的好处。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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BARBARA Ann SOLTZ其他文献
BARBARA Ann SOLTZ的其他文献
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{{ truncateString('BARBARA Ann SOLTZ', 18)}}的其他基金
Laser Activated Collagen Solder for Ophthalmic Surgery
用于眼科手术的激光激活胶原焊料
- 批准号:
6934023 - 财政年份:2005
- 资助金额:
$ 36.52万 - 项目类别:
Laser-Activated Collagen Adhesives for Herniorrhaphy
用于疝修补术的激光激活胶原粘合剂
- 批准号:
6880582 - 财政年份:2002
- 资助金额:
$ 36.52万 - 项目类别:
Laser-Activated Collagen Adhesives for Herniorrhaphy
用于疝修补术的激光活化胶原粘合剂
- 批准号:
6551140 - 财政年份:2002
- 资助金额:
$ 36.52万 - 项目类别:
Laser Assisted Cartilage Repair Using Collagen Adhesives
使用胶原蛋白粘合剂进行激光辅助软骨修复
- 批准号:
6486277 - 财政年份:2002
- 资助金额:
$ 36.52万 - 项目类别:
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