Laser Assisted Cartilage Repair Using Collagen Adhesives

使用胶原蛋白粘合剂进行激光辅助软骨修复

• 批准号: 6486277
• 负责人: BARBARA Ann SOLTZ
• 金额: $ 9.84万
• 依托单位: CONVERSION ENERGY ENTERPRISES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-17 至 2002-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6486277
• 关键词: articular cartilage; biomaterial development /preparation; biomedical equipment development; collagen; histology; laser therapy; limb injury; miniature swine; orthopedics; surgery material /equipment

Articular cartilage damage affects millions of people. This condition is exacerbated by an ageing but increasingly more active population. The two portentous independent variables associated with inferior treatment of articular cartilage lesions are healing response and cartilage regeneration. Laser-assisted welding using a derivatized collagen solder may aid in the prevention of progressive degenerative joint disease and may augment or ultimately replace total joint arthroplasty. We have assembled a multi-disciplinary team to investigate the efficacy of laser activated collagen formulations as an adhesive and as an acellular graft that permits and/or promotes cell invasion. Laser operating parameters will be optimized to promote strong solder crosslinks to cartilage. An integrated temperature controller will be used to prevent peripheral tissue damage. A laser handpiece will be modified for use in the animal studies. Custom designed equipment will be used to accurately measure previously unknown values for inherent solder strength, strength of the repair and type of failure mode. Histology will assess the potential to promote cell invasion and synthesis of new extracellular matrix. It is anticipated that the Phase I results will lay the foundation for further animal studies and clinical trials in subsequent Phase II and Phase III projects. PROPOSED COMMERCIAL APPLICATIONS: The development of laser procedures to repair full thickness articular defects will benefit the millions of people who are suffering from osteoarthritis. This technology may provide orthopaedic surgeons with new techniques which can reduce operating time, convalescence and hospital stays.

关节软骨损害会影响数百万的人。这种情况会因衰老而越来越活跃的人群加剧。与关节软骨劣质治疗相关的两个端积自变量是愈合反应和软骨再生。使用衍生化的胶原焊料进行激光辅助焊接可能有助于预防进行性退行性关节疾病，并可能增加或最终替代总体关节置换术。我们组装了一个多学科团队，以研究激活的胶原蛋白制剂的功效，作为粘合剂和允许和/或促进细胞侵袭的细胞移植物。激光工作参数将被优化，以促进强焊点到软骨。集成的温度控制器将用于防止外围组织损伤。激光手机将用于动物研究中。定制设计的设备将用于准确测量以前未知的值，以实现固有的焊料强度，维修强度和故障模式的类型。组织学将评估促进细胞浸润和合成新的细胞外基质的潜力。预计I期结果将为进一步的动物研究和随后的II期和III期项目奠定基础。拟议的商业应用：开发激光程序以修复完全厚度的关节缺陷将使数百万患有骨关节炎的人受益。该技术可能会为骨科医生提供新技术，这些技术可以减少工作时间，康复和住院。