Laser-Activated Collagen Adhesives for Herniorrhaphy

用于疝修补术的激光活化胶原粘合剂

• 批准号: 6551140
• 负责人: BARBARA Ann SOLTZ
• 金额: $ 9.89万
• 依托单位: CONVERSION ENERGY ENTERPRISES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6551140
• 关键词: adhesions; biomedical equipment development; collagen; gastrointestinal surgery; hernia; laboratory rat; lasers; method development; surgical wound; technology /technique development; tissue engineering; wound healing

DESCRIPTION (provided by applicant): Approximately 1 million inguinal herniorrhaphies are performed annually in the US. Laparoscopic approaches have been developed but clinical acceptance has been hampered by problems such as stability of the mesh fixation, inadequate peritoneal closure, adhesion formation and the probability of internal herniae development. Laser assisted tissue welding using a derivatized collagen solder for tissue/mesh attachment may avoid compression or tissue injury which frequently occurs with mechanical fixation and may offer the additional benefit of minimizing postoperative pain due to tissue ischemia and nerve entrapment syndromes. This study will investigate laser-activated collagen solders for mesh attachment and closure. Laser operating parameters will be optimized to promote strong solder crosslinks to gastrointestinal tissue. An integrated temperature feedback controller will be used to prevent peripheral tissue damage. The proposed study includes the accurate measurement of previously unknown values for inherent solder strength, repair strength and type of failure mode. A surgical handpiece will be modified for use in animal experiments. By comparing a conventional method for mesh fixation to laser attachment, weld integrity, tissue healing and inflammatory response will be defined.

描述（由申请人提供）：美国每年进行大约100万个腹股沟疝气。已经开发了腹腔镜方法，但是诸如网状固定的稳定性，腹膜闭合不足，粘附形成和内部疝气发育的可能性等问题已经阻碍了临床接受。使用衍生化的胶原蛋白焊料进行组织/网状附着的激光辅助组织焊接可能会避免压缩或组织损伤，这经常通过机械固定而发生，并且可能会为最大程度地减少由于组织缺血和神经侵入综合症而导致的术后疼痛的额外好处。这项研究将研究激光激活的胶原蛋白焊料，以进行网状附着和封闭。激光工作参数将被优化，以促进胃肠道组织的强焊点。集成的温度反馈控制器将用于防止外围组织损伤。拟议的研究包括对固有焊料强度，修复强度和故障模式类型的先前未知值的准确测量。手术手机将被修改用于动物实验。通过比较一种传统的网状固定方法与激光附着，焊缝完整性，组织愈合和炎症反应。

项目成果

Preliminary assessment of postoperative adhesion formation after laser-assisted mesh fixation to the peritoneal surface.

激光辅助网片固定腹膜表面后术后粘连形成的初步评估。

• DOI: 10.1089/lap.2005.15.105
• 发表时间: 2005
• 期刊: Journal of laparoendoscopic & advanced surgical techniques. Part A.
• 作者: Lanzafame,RaymondJ;Stadler,Istvan;Brondon,Philip;Soltz,BarbaraA;Devore,DaleP
• 通讯作者: Devore,DaleP

Acute tensile strength analysis of collagen solder for mesh fixation to the peritoneal surface.

用于将网固定到腹膜表面的胶原焊料的急性拉伸强度分析。

• DOI: 10.1007/s00464-004-8909-7
• 发表时间: 2005
• 期刊: Surgical endoscopy
• 作者: Lanzafame,RJ;Soltz,BA;Stadler,I;Soltz,MA;Soltz,R;DeVore,DP
• 通讯作者: DeVore,DP

Histologic assessment of mesh fixation following laser-assisted tissue soldering in a lapine model.

在兔模型中激光辅助组织焊接后的网片固定的组织学评估。

• DOI: 10.1002/lsm.20201
• 发表时间: 2005
• 期刊: Lasers in surgery and medicine.
• 作者: Lanzafame,RaymondJ;Brondon,Philip;Stadler,Istvan;DeVore,DaleP;Soltz,Robert;Soltz,BarbaraA
• 通讯作者: Soltz,BarbaraA