Cross-cultural FASD: Brain Imaging (U24 Core)

跨文化 FASD：脑成像（U24 核心）

• 批准号: 6805722
• 负责人: ELIZABETH R SOWELL
• 金额: $ 16.68万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6805722
• 关键词: Internet; automated data processing; bioimaging /biomedical imaging; biomedical facility; brain imaging /visualization /scanning; brain morphology; clinical research; cooperative study; data collection methodology /evaluation; developmental neurobiology; embryo /fetus toxicology; fetal alcohol syndrome; human subject; image processing; magnetic resonance imaging; mathematics; method development; training

DESCRIPTION (provided by applicant): The overarching goal of this proposed Imaging Core is to understand better the effects of prenatal alcohol exposure on the structure and function of the developing brain by facilitating the use of advanced brain image processing tools by CIFASD members. One of the key limitations in understanding the role of severe prenatal alcohol exposure on the developing brain has been the limited number of subjects studied by any single research group. It is our intent to use this opportunity to pool structural brain imaging data across multiple research sites by standardizing the imaging protocols used to acquire image data, and standardizing image analysis tools used to compare individuals with fetal alcohol spectrum disorders (FASD) to controls. We will use our expertise to provide members of the Consortium with access to relatively simple automated image analysis tools that they can use in their laboratories to assess the shape and size of the corpus callosum (CC) and other regularly shaped brain structures. More specialized tools will be developed to assess differences in brain morphology in cortical and subcortical structures and to combine functional and structural MRI data for within-project functional-structural MRI studies. Specifically, our efforts will be directed towards: 1) the standardization of image acquisition protocols and validation of methods for controlling scanner specific geometric distortion through the use of human and mechanical phantom studies; 2) the adaptation of automated image analysis tools for distribution to CIFASD members; 3) adaptation and creation of more sophisticated tools for assessment of brain shape and tissue distribution abnormalities in cortical and subcortical regions, and the refinement of tools designed to facilitate the combination of functional and structural brain imaging data; and 4) the assessment of relationships between brain image data, and data collected by the other CIFASD projects and cores. Consortium members are proposing to collect either functional or structural (or both) brain imaging data from over 470 children and adolescents with FASD and 310 control subjects. The strategies and methods developed within the Imaging Core will for the first time allow the direct comparison of data collected at various sites, dramatically increasing our power to potentially outline diagnostic criteria from brain imaging data, and ultimately to help develop intervention and treatment approaches for FASD.

描述（由申请人提供）：该提出的成像核心的总体目标是通过促进CIFASD成员使用先进的大脑图像处理工具来更好地了解产前酒精暴露对发育大脑的结构和功能的影响。了解严重产前酒精暴露在发育中的大脑中的作用的关键局限性之一是任何单一研究小组研究的受试者数量有限。我们的意图是利用这一机会通过标准化用于获取图像数据的成像协议以及标准化图像分析工具来汇总多个研究站点的结构性脑成像数据，并标准化了用于比较胎儿酒精谱系障碍（FASD）的人与对照组的分析工具。我们将使用我们的专业知识为财团的成员提供相对简单的自动图像分析工具，可以在实验室中使用，以评估call体（CC）的形状和大小和其他定期形状的大脑结构。将开发更专业的工具来评估皮质和皮质下结构中脑形态的差异，并结合功能和结构MRI数据以进行项目内部功能结构MRI研究。具体而言，我们的努力将针对：1）图像采集方案的标准化以及通过使用人类和机械幻影研究来控制扫描仪特定几何变形的方法的验证； 2）适应自动图像分析工具，用于分发向CIFASD成员； 3）适应和创建更复杂的工具，以评估皮质和皮层下区域中的大脑形状和组织分布异常，以及旨在促进功能和结构脑成像数据组合的工具的完善； 4）评估大脑图像数据之间的关系以及其他CIFASD项目和核心收集的数据。财团成员提议收集470多名FASD儿童和青少年的功能或结构性（或两者）脑成像数据和310名对照对象。成像核心内开发的策略和方法将首次允许在各个站点收集的数据进行直接比较，从而极大地增加了我们从脑成像数据中概述诊断标准的能力，并最终帮助开发FASD的干预和治疗方法。