GAS-II

气体-II

• 批准号: 7609609
• 负责人: GULIZ ERDEM
• 金额: $ 1.57万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7609609
• 关键词: Acute; Acute Pharyngitis; Adhesions; Antibodies; Antibody Formation; Bacteria; Blood; Cardiac Myosins; Child; Clinical; Computer Retrieval of Information on Scientific Projects Database; Consent; Control Groups; Data; Disease; Doctor of Philosophy; Follow-Up Studies; Funding; Grant; Human; Incidence; Institution; Invasive; Methodology; Oklahoma; Pathogenesis; Patients; Pharyngeal structure; Pharyngitis; Property; Protocols documentation; Purpose; Research; Research Ethics Committees; Research Infrastructure; Research Personnel; Resources; Rheumatic Fever; Schools; Screening procedure; Serum; Source; Staging; Streptococcus; Streptococcus pyogenes; Students; Testing; United States National Institutes of Health; Universities; streptococcal M protein

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This will be a follow up study to the previously approved study entitled, Epidemiologic and Adhesion Properties of Group A Streptococci in a Region with a High Incidence of Acute Rheumatic Fever (CRC Protocol #2002-04, HPH IRB RP#02-59). In the former study, 955 school children, grades K-12, from 11 public and private schools on Oahu, were screened between April 2003 and October 2003 for pharyngeal carriage of group A streptococcus. Of these 955 students, 32 of them tested positive for group A streptococcus. These students are potential carriers of this bacterium. The streptococcal isolates from these children are emm/M typed. We have identified rather unusual emm/M types from these students similar to the data obtained from patients with pharyngitis or invasive disease. We would like to conduct this follow-up study for several purposes: 1. To repeat throat cultures from these carriers in order to find if they still carry the same type of streptococcus. 2. To obtain sera from these carriers to study. We would like to collect blood (12 ml.) from consenting subjects to study ASO titers, anti-streptococcal M protein and anti-human cardiac myosin antibodies. The last two antibodies will be studied at the University of Oklahoma by a study collaborator who has extensive research on the pathogenesis of acute rheumatic fever (Madeleine Cunningham, PhD). 3. To include a control group of 80 patients with acute pharyngitis to compare antibody responses. We estimate screening 80 patients in order to obtain at least 35 patients who have a positive throat culture for group A streptococcus. Specific antibody responses are probably the only known methodology that can accurately differentiate the carrier stage from acute pharyngitis patients. Therefore, these studies are necessary to perform further analysis of the carriers. CRC infrastructure support, including ancillary funds, use of the clinical facility, and research personnel support, are requested in order to conduct this study.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 这将是对先前批准的研究的后续研究，标题为急性风湿热发病率高的地区A组链球菌的流行病学和粘附特性（CRC协议＃2002-04，HPH IRB RP＃02-59 ）。 在以前的研究中，2003年4月至2003年10月在2003年4月至2003年10月在A组的A链球菌运输的955名K-12年级的K-12年级，来自瓦胡岛的11个公立和私立学校。 在这955名学生中，其中32名对A组链球菌的测试呈阳性。 这些学生是该细菌的潜在携带者。 来自这些儿童的链球菌分离株是EMM/M键入的。 我们已经从这些学生那里发现了相当不寻常的EMM/M类型，类似于从咽炎或侵入性疾病患者中获得的数据。 我们想为了几个目的进行这项后续研究： 1。从这些载体中重复喉咙培养物，以查找它们是否仍携带相同类型的链球菌。 2。从这些载体中获取血清进行研究。 我们想从同意的受试者中收集血液（12毫升），以研究ASO滴度，抗链球菌M蛋白和抗人类心脏肌球蛋白抗体。 最后两种抗体将在俄克拉荷马大学进行研究，该研究合作者对急性风湿热的发病机理进行了广泛的研究（Madeleine Cunningham，PhD）。 3。包括一个由80例急性咽炎患者组成的对照组，以比较抗体反应。 我们估计80名患者，以便至少获得35例对A组链球菌具有阳性喉咙培养的患者。 特异性抗体反应可能是唯一可以将载体阶段与急性咽炎患者进行准确区分的方法。 因此，这些研究对于对载体进行进一步分析是必要的。 为了进行这项研究，请求CRC基础设施支持，包括辅助基金，临床设施的使用以及研究人员支持。