UHI COBRE: P3: GROUP A STREPT IN RELATION TO ACUTE RHEUMATIC FEVER IN HAWAII

UHI COBRE：P3：A 组链球菌与夏威夷急性风湿热相关

• 批准号: 7381988
• 负责人: GULIZ ERDEM
• 金额: $ 25.01万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381988
• 关键词: UHI; COBRE; P3; GROUP; STREPT

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Infections caused by group A streptococci (GAS) lead to a wide spectrum of diseases, ranging from relatively benign conditions to invasive diseases and serious nonsuppurative sequelae, such as acute rheumatic fever (ARF). While the incidence of ARF has declined dramatically in industrialized countries, ARF remains the leading cause of acquired heart disease among children in many developing countries. For unknown reasons, the annual incidence rate of ARF in Hawaii has continued to be 40-fold higher than that on the continental U.S., particularly among native Hawaiians and other Polynesian ethnic groups. Preliminary studies indicate that pharyngeal infection-associated GAS M protein serotypes (the so-called rheumatogenic types), which are known to be associated with ARF, are infrequently isolated from ARF patients in Hawaii. Instead, unusual M types of GAS have been identified in local patients with ARF or with invasive and non-invasive GAS diseases. The objective of this research project is to determine the molecular epidemiology and adhesion properties of GAS in native Hawaiians and other Polynesian groups. The central hypothesis is that pharyngeal carriage of skin-associated and unusual M types of GAS accounts for high-incidence ARF and other streptococcal diseases in Hawaii. The proposed five-year study will test our hypothesis by pursuing the following specific aims: 1. Characterize the GAS in Hawaii and evaluate the epidemiologic factors that correlate with the high incidence of ARF in native Hawaiians and other Polynesian ethnic groups. 2. Assess the GAS pharyngeal carrier status in different ethnic groups, as well as the adhesion properties of GAS in carriers and patients with ARF and invasive GAS disease in Hawaii. This project is innovative because it will provide new knowledge about the diversity of GAS M proteins and their association with ARF and other streptococcal diseases and their sequelae. Our full expectation at the conclusion of this project is that we will know the diversity of M types in Hawaii. This information will have a significant impact on the development of vaccines for ARF and invasive and non-invasive GAS diseases.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。 A 族链球菌 (GAS) 引起的感染会导致多种疾病，从相对良性的病症到侵袭性疾病和严重的非化脓性后遗症，例如急性风湿热 (ARF)。尽管 ARF 的发病率在工业化国家已大幅下降，但 ARF 仍然是许多发展中国家儿童获得性心脏病的主要原因。由于未知的原因，夏威夷 ARF 的年发病率持续比美国大陆高 40 倍，特别是在夏威夷原住民和其他波利尼西亚族群中。初步研究表明，已知与 ARF 相关的咽部感染相关 GAS M 蛋白血清型（所谓的风湿性类型）很少从夏威夷 ARF 患者中分离出来。相反，在当地患有 ARF 或患有侵袭性和非侵袭性 GAS 疾病的患者中发现了不寻常的 M 型 GAS。该研究项目的目的是确定夏威夷原住民和其他波利尼西亚群体中 GAS 的分子流行病学和粘附特性。核心假设是，咽部携带与皮肤相关的和不寻常的 M 型 GAS 是夏威夷 ARF 和其他链球菌疾病高发的原因。拟议的五年研究将通过追求以下具体目标来检验我们的假设： 1. 描述夏威夷的 GAS 特征并评估与夏威夷原住民和其他波利尼西亚族群中 ARF 高发病率相关的流行病学因素。 2.评估不同种族人群GAS咽部携带者状况，以及夏威夷ARF和侵袭性GAS疾病携带者和患者中GAS的粘附特性。 该项目具有创新性，因为它将提供有关 GAS M 蛋白多样性及其与 ARF 和其他链球菌疾病及其后遗症的关联的新知识。我们对该项目结束的全部期望是我们将了解夏威夷 M 类型的多样性。这些信息将对 ARF 以及侵袭性和非侵袭性 GAS 疾病疫苗的开发产生重大影响。