UHI COBRE: P3: GROUP A STREPT IN RELATION TO ACUTE RHEUMATIC FEVER IN HAWAII

UHI COBRE：P3：A 组链球菌与夏威夷急性风湿热相关

• 批准号: 7171207
• 负责人: GULIZ ERDEM
• 金额: $ 26.31万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171207
• 关键词: Hawaii; Pacific Islands; clinical research; communicable disease transmission; emerging infectious disease; human papillomavirus; human subject; molecular pathology

DESCRIPTION (provided by applicant): In response to a regional resurgence of infectious diseases and consistent with a high-priority institutional initiative to establish the Asia-Pacific Institute for Tropical Medicine and Infectious Diseases, this application proposes to develop the Pacific Center for Emerging Infectious Diseases Research at the University of Hawai'i at Manoa. By drawing on the complementary strengths and expertise within the John A. Burns School of Medicine, the Pacific Biomedical Research Center, and the Cancer Research Center of Hawai'i, as well as the State of Hawai'i Department of Health, the new Center will be anchored by the tenets of trans-disciplinary research. Projects will be linked by a unifying research focus on the molecular epidemiology and pathogenesis of infectious diseases, which are of local and regional relevance and which disproportionately affect under-served ethnic minority communities in Hawai'i and the Asia-Pacific region. Specifically, studies will be conducted on the natural history of human papillomavirus infection in heterosexual men, the immunopathogenesis of dengue fever, and the molecular epidemiology and adhesion properties on group A streptococci in relation to high-incidence acute rheumatic fever in Hawai'i. Newfound knowledge from these research projects will provide improved strategies for prevention and control of these regionally important infectious diseases. The overall objectives of the proposed Center will be achieved by the following specific aims: 1. Build institutional capacity by mentoring a cadre of promising young faculty to conduct research on infectious diseases of medical importance to the Asia-Pacific region. 2. Improve research competitiveness by enhancing the capacity for mentoring and expanding the capability of the technical support infrastructure. 3. Diversify the research breadth and trans-disciplinary scope of the Center through targeted recruitment and retention of funded faculty with complementary expertise and through centralization of laboratory space and research-support operations.

描述（由申请人提供）： 为了应对传染病的区域复兴，并与建立亚太地区热带医学和传染病研究所建立高优先级的机构倡议一致，该申请旨在开发太平洋新兴的传染病中心。 '我在马诺阿。通过利用约翰·A·伯恩斯医学院，太平洋生物医学研究中心和夏威夷癌症研究中心以及夏威夷卫生部的互补优势和专业知识，新中心将由跨学科研究的宗旨锚定。统一的研究重点是传染病的分子流行病学和发病机理，这些研究将与局部和区域相关性的分子发病机理联系起来，这些项目将与夏威夷和亚太地区和亚太地区的少数民族社区的不成比例产生不成比例。具体而言，将对异性恋男性的人类乳头瘤病毒感染的自然史，登革热的免疫发作以及A组的分子流行病学和粘附特性在Hawai'i中与高收入性急性流风湿发烧有关。这些研究项目的新知识将为预防和控制这些重要的传染病提供改进的战略。拟议中心的总体目标将通过以下特定目的实现： 1。通过指导有前途的年轻教师的干部来建立机构能力，以研究对亚太地区的医学重要性的传染病研究。 2.通过提高指导和扩大技术支持基础设施能力的能力来提高研究竞争力。 3.通过有针对性的招聘和保留资助的教师的互补专业知识以及实验室空间和研究支持操作的集中化，通过有针对性的招聘和保留资助的教职员工来多样化研究中心的广度和跨学科范围。