Etiology and Consequences of Adolescent Drug Use(K05)

青少年吸毒的病因和后果（K05）

基本信息

批准号：
7388248
负责人：
JUDITH S BROOK
金额：
$ 12.67万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
1995
资助国家：
美国
起止时间：
1995-03-15 至 2010-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7388248
关键词：
Acculturation Achievement Acquired Immunodeficiency Syndrome Address Adolescence Adolescent Adult Affect African African American Age Aggressive behavior Agoraphobia Alcohol consumption Alcohol dependence Alcohol or Other Drugs use Alcohols Anger Anxiety Disorders Area Attention Attention deficit hyperactivity disorder Attenuated Attitude Behavior Behavioral Bipolar Disorder Brothers Buffers Characteristics Child Child Abuse and Neglect Child Rearing Childhood Church Cigarette Cigarette Smoker Climacteric Cognitive Collaborations Communities Community Participation Comorbidity Condition Conflict (Psychology)Coping Behavior County DSM-IV Daily Data Data Collection Data Set Demographic Factors Dependence Development Discipline Disease Disease regression Divorce Drug Addiction Drug Formulations Drug abuse Drug resistance Drug usage Eating Disorders Education Emotional Employment Ensure Environment Environmental Risk Factor Equation Ethnic Origin Ethnic group Etiology Event Factor Analysis Faculty Family Family Relationship Fathers Female Frequencies Friends Fright Funding Future Gender Generalized Anxiety Disorder Generations Genetic Goals Graph Growth HIV Health Home environment Illicit Drugs Impulsivity Income Individual Injection of therapeutic agent Intervention Interview Interviewer Investigation Knowledge Lead Legal Life Link Literature Logistics Longevity Longitudinal Studies Lung diseases Major Depressive Disorder Malaise Maps Marijuana Marriage Marriage Postponements Measures Mediating Mediator of activation protein Medical Students Mental Depression Mental disorders Mentors Methods Minority Modeling Mother-Child Relations Mothers Neighborhoods Neurobehavioral Manifestations Neurocognitive New York Nicotine Nicotine Dependence Nicotine Withdrawal Numbers Occupational Occupations Panic Disorder Paper Parent-Child Relations Parenting behavior Parents Participant Pathway interactions Pattern Performance Perinatal Personality Personality Disorders Personality Traits Pharmaceutical Preparations Phase Plant Roots Platelet Factor 4 Policy Research Population Positioning Attribute Pregnancy Prevention Prevention program Price Principal Investigator Probability Problem behavior Procedures Process Progress Reports Psychiatric Diagnosis Psychological adjustment Psychopathology Psychosocial Factor Public Policy Publications Publishing Puerto Rican Questionnaires Range Recording of previous events Regression Analysis Religion and Spirituality Research Research Personnel Respiration Disorders Risk Risk Behaviors Risk Factors Role Role playing therapy Running Sampling Schools Self-Administered Severities Siblings Smoke Smoking Sorting - Cell Movement Source Specific qualifier value Spouses Staging Structure Substance Addiction Substance Use Disorder Suicide Suicide attempt Symptoms Taxation Techniques Television Temperament Testing Time Tobacco Tobacco Use Cessation Tobacco use Toddler Training Unemployment Validity and Reliability Violence Work Youth adolescent drug abuse adolescent drug use adolescent smoking anti social base biological adaptation to stress career cigarette smoking cohort criminal behavior cultural values day deviant distilled alcoholic beverage drug abuser experience gene environment interaction high risk sexual behavior inner city instrument interest intergenerational male maternal cigarette smoking maternal drug use middle age neglect neurobehavioral next generation non-smoking optimism peer preadolescence prevent programs prospective protective effect psychosocial respiratory sex smoking cessation social suicidal behavior teenage mother theories transmission process tv watching young adult

项目摘要

DESCRIPTION (provided by applicant): This is a resubmission of a competing continuation application for a SSA. The major goals are to extend research on: (1) risk and protective factors involved in adult tobacco and drug use/abuse/dependence, extending into early mid-life; (2) testing models of pathways to tobacco and drug use/abuse/dependence; (3) interactive effects of risk and protective factors; and (4) consequences of tobacco and drug use on adolescent and adult functioning. To achieve this, I wilt expand prior research by: (1) including samples of inner-city youngsters and parental drug abusers; (2) comparing the etiologies of tobacco and drug use/abuse/dependence, and their relation to psychopathology; (3) studying the intra- and intergenerational transmission of drug-prone characteristics; (4) examining cultural factors associated with tobacco and drug use/abuse/dependence; (5) studying the interaction of genetic and environmental factors on drug use/abuse/dependence; and (6) examining factors related to AIDS transmission behavior and coping with AIDS. In order to achieve these goals, an integrated program of research is underway, involving five funded large-scale projects: Studies 1A and 1B: Longitudinal studies of 976 children from ages 1-10 to early mid-life and their mothers; Studies 2A and 2B: Studies of African-American and Puerto Rican inner city youth and their mothers; Study 3: A multigenerational study of 324 offspring of the original study children in Study 2A; Study 4: A study of Black and White South African adolescents, age 12-17; Study 5: A study of 500 male HIV+ and HIV- injection drug-using fathers and their children; Study P1: A study of childhood factors for drug use/abuse extending into early mid-life, and Study P2: A study of gene-environment interactions related to drug use. The major significance of this program of integrated research is that it addresses many critical issues in the field of substance use (e.g., what are the risks for tobacco and drug use throughout the developmental span of childhood to adulthood; what can protect against these risks in different populations, including those implicated in the spread of AIDS; how can one break the transmission of risk from one generation to the next; and what are the factors associated with cessation of tobacco and drug use.) The K05 will enable me to devote my time and energy to research goals such as substantive and methodological development, mentoring activities (30% time), including guidance of medical students and junior faculty, and my own career development.

描述（由申请人提供）：这是SSA竞争连续申请的重新提交。主要目标是扩展对：（1）成人烟草和毒品使用/滥用/依赖的风险和保护因素，并延伸到中期早期；（2）测试烟草和药物使用/滥用/依赖的途径模型；（3）风险和保护因素的交互作用；（4）烟草和吸毒对青少年和成人功能的后果。为了实现这一目标，我通过以下方式扩展了先前的研究：（1）包括内城年轻人和父母滥用药物的样本；（2）比较烟草和药物使用/滥用/依赖的病因及其与精神病理学的关系；（3）研究易药特征的内部和代际传播；（4）检查与烟草和药物使用/滥用/依赖性相关的文化因素；（5）研究药物使用/滥用/依赖性遗传和环境因素的相互作用；（6）检查与艾滋病传播行为和应对艾滋病有关的因素。为了实现这些目标，正在进行一项综合研究计划，涉及五个资助的大规模项目：研究1A和1B：对976名1-10岁至中年早期及其母亲的976名儿童的纵向研究；研究2a和2b：非裔美国人和波多黎各内城青年及其母亲的研究；研究3：研究2a中最初研究儿童的324个后代的多代研究；研究4：对南非黑人青少年的研究，年龄12-17岁；研究5：对500名男性HIV+和HIV注射药物的父亲及其子女的研究；研究P1：对延伸到中期早期的药物使用/滥用童年因素的研究，并研究P2：研究与药物使用相关的基因环境相互作用的研究。该集成研究计划的主要意义是它解决了物质使用领域的许多关键问题（例如，在整个儿童期到成年期间，烟草和吸毒的风险是什么；什么可以防止这些免受这些风险不同的人口，包括与艾滋病的传播有关的人群；时间和精力进行研究目标，例如实质性和方法论发展，指导活动（30％的时间），包括医学生和初级教师的指导以及我自己的职业发展。