FAMILIAL DETERMINANTS OF HYPERTENSION

高血压的家族决定因素

• 批准号: 7375055
• 负责人: Theodore Kotchen
• 金额: $ 47.23万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375055
• 关键词: FAMILIAL; DETERMINANTS; HYPERTENSION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We hypothesize that we will be able to identify genes contributing to hypertension in African Americans by focusing on physiological pathways that determine arterial pressure. The design is a case-control study involving hypertensive and normotensive African Americans. This protocol involves a single outpatient visit during which the following are obtained: brief history, standardized blood pressure, anthropometric measurements; peripheral venous blood for a basic chemistry panel and DNA. Based on thie information, subjects satisfying inclusion criteria will be invited to participate in a related inpatient protocol, which involves more extensive phenotyping.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。我们假设我们将能够通过专注于确定动脉压的生理途径来识别有助于非裔美国人高血压的基因。该设计是一项涉及高血压和正常非裔美国人的病例对照研究。该协议涉及单一的门诊就诊，在此期间获得以下访问：简短的病史，标准化的血压，人体测量值；基本化学面板和DNA的外周静脉血。根据THIE信息，将邀请满足包含标准的受试者参加相关的住院方案，该方案涉及更广泛的表型。