GENES OF HYPERTENSION IN AFRICAN AMERICANS

非裔美国人的高血压基因

• 批准号: 7375056
• 负责人: Theodore Kotchen
• 金额: $ 43.63万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375056
• 关键词: GENES; HYPERTENSION; AFRICAN; AMERICANS; GENES; HYPERTENSION; AFRICAN; AMERICANS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We hypothesize that we will be able to identify genes contributing to hypertension in African Americans by focusing on the physiological pathways that determine arterial pressure. We propose to extensively phenotype 500 hypertensive and 500 normotensive African American subjects to conduct a genetic association study, using a SNP genomic scan approach. Inclusion of phenotypes is based on their relevance to the pathophysiology of hypertension and prior evidence of "heritability". Candidate genes for SNP analysis will be based on QTLs previously identified by ourselves and others. A final goal of the project is to determine if distinct clusters of blood pressure-related phenotypes can be identified that will permit stratification of hypertensive individuals into distinct subgroups to facilitate the analysis of the genetic determinants of hypertension.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。我们假设我们将能够通过专注于确定动脉压的生理途径来识别有助于非裔美国人高血压的基因。我们建议使用SNP基因组扫描方法进行广泛的表型500高血压和500名非裔美国人受试者进行遗传关联研究。包括表型基于它们与高血压的病理生理学和先前的“遗传力”证据的相关性。用于SNP分析的候选基因将基于我们自己和他人先前确定的QTL。该项目的最终目标是确定是否可以确定与血压相关表型的不同簇，以允许高血压个体分层为不同的亚组，以促进对高血压的遗传决定因素的分析。