EFFECT OF EXERCISE & SLEEP DEPRIVATION ON THE DEVELOPMENT OF CMI SYMPTOMS

运动的效果

• 批准号: 7376548
• 负责人: JENNIFER M GLASS
• 金额: $ 3.17万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-05 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376548
• 关键词: advertising; data collection; employee; ethnic group; exercise; fatigue; female; gait; heart rate; housing; information systems; interview; male; memory; pain; questionnaires; reading; saliva; sleep; sleep deprivation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Commitment to this study spans 24 days: 7 days of baseline, 10 days of a study assignment (exercise deprivation, sleep restriction, both, or nothing), and 7 days follow-up. To evaluate sleep/activity patterns, participants will wear an activity monitor for the duration of the study. It will prompt them to rate pain, fatigue and mood 3x throughout each day. For three days (3x/day) during baseline and following deprivation, subjects will collect saliva, using specifically designed kits. For one of these days, participants will wear a Holter (heart rate) monitor. To evaluate the influence of aerobic capacity on symptom development, participants will undergo a treadmill test at baseline, and at the end of their study assignment. Additionally, participants will complete self-report questionnaires, undergo several standardized cognitive (memory) tasks, and a pressure pain assessment. The population for this study includes healthy runners from Ann Arbor, MI and vicinity. All ethnic groups are eligible to participate, although the local population is predominately Caucasian, with equal male/female representation. Participants will be recruited via advertisements distributed among local running stores/clubs, gyms, and newspapers. Each of four study groups will contain 32 subjects with roughly equal numbers of males and females in each cell, for a total of 128 subjects. Once in the study, participants will be randomized: sleep deprivation, exercise deprivation, sleep+exercise deprivation, or normal activity. Identifying information will not be stored in the study databases, but will be housed in a secure data file on a limited access, non-networked, password-protected workstation. Prior to any data collection, participants will undergo an informed consent interview with a nurse practitioner. Participants will be given a copy of the consent document and ample time to read it, a verbal explanation of the protocol, and an opportunity to ask questions. Participants will then be asked to sign the informed consent document. An employee of UMHS with no direct involvement in the study will witness the signing of two copies of the informed consent document, one each for the participant and the study file. This file will be secured in a double-locked setting within the UMHS.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。对这项研究的承诺跨度为24天：基线的7天，学习任务的10天（运动剥夺，睡眠限制，或没有）和7天的随访。为了评估睡眠/活动模式，参与者将在研究期间佩戴活动监护仪。这将促使他们每天都要评估疼痛，​​疲劳和情绪3倍。在基线和剥夺之后，在三天（3倍/天）中，受试者将使用专门设计的工具包收集唾液。在这些日子中，参与者将佩戴Holter（心率）监测器。为了评估有氧运动能力对症状发展的影响，参与者将在基线和研究任务结束时进行跑步机测试。此外，参与者将填写自我报告问卷，执行几项标准化的认知（记忆）任务以及压力疼痛评估。 这项研究的人口包括来自安阿伯，密歇根州和附近的健康跑步者。尽管当地人口主要是高加索人，但男性/女性的代表性相同，但所有种族都有资格参加。参与者将通过在本地跑步商店/俱乐部，健身房和报纸上分发的广告招募。四个研究组中的每一个将包含32名受试者，每个细胞中的男性和女性数量大致相等，总共128名受试者。一旦研究，参与者将被随机分配：睡眠剥夺，运动剥夺，睡眠+运动剥夺或正常活动。识别信息将不会存储在研究数据库中，而是将其存储在有限的访问，非网络，密码保护工作站的安全数据文件中。在收集任何数据之前，参与者将接受护士从业者的知情同意采访。参与者将获得同意文件的副本，并有足够的时间阅读该文件，对协议的口头解释以及提出问题的机会。然后，将要求参与者签署知情同意文件。没有直接参与研究的UMHS的雇员将见证签署两份知情同意文件的副本，每份参与者和研究文件分别签署。该文件将在UMHS内的双锁定设置中固定。