Cognitive Function & Executive Control in Fibromyalgia

认知功能

• 批准号: 6660769
• 负责人: JENNIFER M GLASS
• 金额: $ 7.65万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-20 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6660769
• 关键词: behavior test; behavioral /social science research tag; chronic pain; clinical research; cognition; cognition disorders; computer program /software; disease /disorder etiology; fatigue; fibromyalgia; functional ability; human middle age (35-64); human subject; longitudinal human study; major depression; neuropsychological tests; rheumatoid arthritis; short term memory; young adult human (21-34)

DESCRIPTION (provided by applicant): Fibromyalgia (FM) is a disorder characterized by widespread musculoskeletal pain and the presence of tender points. Other symptoms, including fatigue, sleep disturbance and neuropsychological complaints contribute significantly to the morbidity associated with FM. One of the most prominent complaints in patients with FM is impaired cognitive ability. However, there is limited data on actual cognitive function in FM. Nonetheless, these cognitive complaints interfere with work and disrupt the lives of FM patients. The data available from our current work on cognitive function in FM and from other research, point toward a deficit in executive control of cognitive processes, especially working memory. Two experiments are proposed that will investigate various aspects of executive control and task-switching ability. The design includes standard neuropsychological tests as well as techniques developed in cognitive psychology. The latter techniques involve manipulation of experimental factors such as delay between encoding and recall that affect particular cognitive processes, such as decay from memory. This type of design allows a detailed view of the specific cognitive processing mechanisms that are affected in FM. Because FM is associated with other symptoms that could impact cognitive function, two special control groups are included in the design in addition to healthy controls. A group of rheumatoid arthritis patients will provide a control for the attentional demands of managing chronic pain. A group of depressed patients will provide a control for depression in FM, since patients with FM frequently report more depressive symptoms than healthy controls. We hypothesize that FM is associated with cognitive dysfunction that cannot be explained solely on the basis of pain or depression. This research will lead to a better understanding of the characterization of cognitive dysfunction in FM, as well as the potential causes of this dysfunction. The emphasis on executive control processes is important because these are critical in many demanding work and life situations.

描述（由申请人提供）：纤维肌痛（FM）是一种疾病，其特征是肌肉骨骼疼痛和嫩点的存在。其他症状，包括疲劳，睡眠障碍和神经心理上的抱怨，对与FM相关的发病率显着贡献。 FM患者中最突出的抱怨之一是认知能力受损。 但是，FM中实际认知功能的数据有限。尽管如此，这些认知抱怨会干扰工作并破坏FM患者的生活。我们目前关于FM和其他研究中认知功能的工作可获得的数据，指出了对认知过程的执行控制，尤其是工作记忆的不足。提出了两个实验，这些实验将研究执行控制和任务切换能力的各个方面。该设计包括标准的神经心理学测试以及认知心理学中开发的技术。后一种技术涉及操纵实验因素，例如影响特定认知过程的编码和回忆之间的延迟，例如记忆的衰减。这种类型的设计允许详细了解FM中受影响的特定认知处理机制。由于FM与可能影响认知功能的其他症状相关，因此除了健康对照组外，设计中还包括两个特殊的对照组。一组类风湿关节炎患者将控制控制慢性疼痛的注意力需求。一组抑郁症患者将为FM提供抑郁症的控制，因为FM患者经常报告的抑郁症状比健康对照组更多。我们假设FM与认知功能障碍有关，而这些功能障碍不能仅根据疼痛或抑郁而解释。这项研究将更好地理解FM认知功能障碍的表征，以及该功能障碍的潜在原因。对执行控制过程的强调很重要，因为这些工作对于许多苛刻的工作和生活状况至关重要。