SMOKING AND METABOLIC COMPLICATIONS

吸烟和代谢并发症

• 批准号: 7374522
• 负责人: LORAH Denise DORN
• 金额: $ 9.33万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7374522
• 关键词: SMOKING; METABOLIC; COMPLICATIONS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Adolescence is a time of vulnerability for youth where depression rates increase, particularly in girls, and smoking behaviors are also initiated. Increased morbidity and mortality in women who are smokers has been highlighted by recent statistics showing that women now have an increased rate of smoking over the last several decades. Morbidity and mortality is usually defined by cardiovascular and respiratory disorders. Less attention has been paid to the effect of smoking on aspects of health such as the relationship between smoking and depression and anxiety, and in turn, their combined effects on reproductive and bone health. No studies have examined such issues in puberty. The aims of this study are to examine: (1) baseline relationships between puberty, smoking status, depression anxiety, reproductive and bone health, (2) causal direction between smoking status and depression and anxiety across 3 years, (3) characteristics of individual differences in developmental trajectories of: (a) reproductive and (b) bone health (accrual of bone mineral content; BMC) across a 3 year period, (4) the systematic effects of timing of puberty, smoking status and depression and anxiety on individual differences in developmental trajectories of reproductive and bone health (accrual of BMC) across a 3 year period, (5) the relationship of individual differences in developmental trajectories of adolescent reproductive health with individual differences in developmental trajectories of bone health across a 3 year period, and (6) whether baseline levels of smoking status, depression, and pubertal timing predict the simultaneous developmental trajectories of reproductive and bone health. The study will include 252 girls, ages 11-17 years enrolled in a cross-sequential design for three annual visits. Measures include smoking status, depression and anxiety, pubertal timing, gonadal and adrenal hormones, menstrual cycle information, and accrual of BMC. Examining the combined impact of smoking, depression and anxiety, on timing of puberty has import for future intervention and prevention strategies. Any negative influence during this critical period, such as smoking or depression, may have significant long-term consequences for bone (i.e. increased risk of osteoporotic fracture) or reproductive health (i.e. menstrual irregularity & endocrine disruption, infertility, dysmenorrhea).

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。青春期是青少年的脆弱时期，抑郁症发病率增加，尤其是女孩，并且吸烟行为也开始出现。最近的统计数据突显了女性吸烟者发病率和死亡率的增加，显示过去几十年来女性吸烟率有所增加。发病率和死亡率通常由心血管和呼吸系统疾病来定义。人们很少关注吸烟对健康的影响，例如吸烟与抑郁和焦虑之间的关系，以及它们对生殖和骨骼健康的综合影响。没有研究探讨青春期的此类问题。本研究的目的是检查：(1) 青春期、吸烟状况、抑郁焦虑、生殖和骨骼健康之间的基线关系，(2) 三年内吸烟状况与抑郁和焦虑之间的因果关系，(3) 个体特征3 年期间以下方面发育轨迹的差异：(a) 生殖和 (b) 骨骼健康（骨矿物质含量的增加；BMC），(4) 青春期时间、吸烟状况以及抑郁和焦虑对个体的系统影响差异3年期间生殖和骨骼健康的发展轨迹（BMC的累积），（5）青少年生殖健康发展轨迹的个体差异与3年期间骨健康发展轨迹的个体差异的关系，以及(6)吸烟状况、抑郁和青春期时间的基线水平是否可以预测生殖和骨骼健康的同步发育轨迹。该研究将纳入 252 名年龄在 11 至 17 岁的女孩，参与交叉序列设计，每年进行 3 次访问。衡量指标包括吸烟状况、抑郁和焦虑、青春期时间、性腺和肾上腺激素、月经周期信息以及 BMC 累积。研究吸烟、抑郁和焦虑对青春期时间的综合影响对于未来的干预和预防策略很重要。在此关键时期的任何负面影响，例如吸烟或抑郁，都可能对骨骼（即骨质疏松性骨折的风险增加）或生殖健康（即月经不规律和内分泌干扰、不孕、痛经）产生重大的长期后果。