CSRD Research Career Scientist Award Application

CSRD研究职业科学家奖申请

• 批准号: 10657600
• 负责人: Judith M Ford
• 金额: --
• 依托单位: VETERANS AFFAIRS MED CTR SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2029-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10657600
• 关键词: Address; Advocate; American; Anesthesiology; Animals; Anxiety; Appointment; Asthma; Attention; Auditory; Auditory Hallucination; Award; Behavior; Behavioral Sciences; Biological Psychiatry; Blood; Blood Vessels; Brain; Brain imaging; COVID-19; COVID-19 complications; COVID-19 impact; COVID-19 long hauler; COVID-19 survivors; Cerebellum; Chronic; Clinical; Clinical Medicine; Clinical Trials; Cognition; Cognitive; Cognitive deficits; Collaborations; Congresses; Conscious; Delusions; Diagnostic; Diet; Distress; Doctor of Philosophy; Educational process of instructing; Electroencephalography; Elements; Emotions; Environment; Esthesia; Event; Family; First Degree Relative; Foundations; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Grant; Group Meetings; Hallucinations; Human; Hypertension; International; Judgment; Ketones; Leadership; Learning; Life; Link; Long COVID; Longevity; Lung; Magnetic Resonance Imaging; Major Depressive Disorder; Malignant Neoplasms; Medicine; Mental Depression; Mental Health; Mentors; Metabolic syndrome; Methods; Mind; Mindfulness Training; Morbidity - disease rate; Motor; Neurobiology; Neurosciences; Obesity; Parietal; Participant; Patients; Perception; Persons; Phase; Physicians; Pontine structure; Population; Psychiatrist; Psychiatry; Psychological Tests; Psychologist; Psychoses; Qualifying; Radiologic Health; Radiology Specialty; Research; Research Personnel; Residual state; Review Committee; Role; Sampling; Schizophrenia; Scientist; Sensory; Severities; Signal Transduction; Smoking; Societies; Stimulus; Structure; Symptoms; System; Talents; Thinking; Translating; United States National Institutes of Health; Veterans; Work; Youth; biomarker identification; body system; career; clinical risk; clinically significant; college; coronavirus disease; cost; deficit syndrome; disability; editorial; experience; functional magnetic resonance imaging/electroencephalography; high risk; imaging modality; information processing; ketogenic diet; long term consequences of COVID-19; meetings; member; mindfulness; mortality; neural; neural network; neuroimaging; neuropsychopharmacology; operation; post SARS-CoV-2 infection; programs; radiologist; recruit; response; rumination; schizophrenia spectrum disorder; virtual

Dr. Ford is an established investigator in neuroscience and psychiatry, with a PhD in neuroscience and life-long appointments in mental health/psychiatry. She uses electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), to investigate the neurobiology of schizophrenia (SZ) and major depressive disorder (MDD). And now, she is adding COVID19 “long haulers” to the conditions she studies with brain imaging methods. SZ. Dr. Ford’s work in SZ was focused on an elemental neural system that dampens neural responses to self- generated stimuli compared to stimuli arising from the environment. It is thought to reflect the operation of an efference copy/corollary discharge mechanism involving signaling from motor to sensory regions, preparing sensory regions for self-generated sensory events. This mechanism is ubiquitous across all animal species, and her work in translating this mechanism to a human paradigm has uncovered a fundamental deficit in sensory information processing in people on the psychosis spectrum. With NIH R01 funding, she has shown deficiencies in these mechanisms are linked to auditory hallucinations and delusions. With current NIH R03 funding, she is now asking about the role of the thalamo-pontine-cerebellar circuit in the successful operation of this system. Two of Dr. Ford’s VA trainees are now extending this work to a new sample of people with psychosis, their 1st degree relatives, youth at clinical risk for developing psychosis, and non-affected control participants. They are finding connectivity between cerebellum and pons is related to the action of the efference copy/corollary discharge mechanism. With a more recently funded NIH R03 grant, she is asking whether EEG-assessed slowed perception has upstream effects on cognition and contributes to clinical features of psychosis in the schizophrenia spectrum. With a to-be-funded mechanistic clinical trial (NIH R21) involving a VA psychiatrist, a VA radiologist, and a UCSF cardiologist, she is asking whether a ketogenic diet can restore neural network stability in SZ, thereby addressing both cognitive deficits and metabolic syndrome, associated with poor function and a shortened life span, respectively. MDD/SZ. About 4 years ago, she added MDD to the clinical populations she studies and is asking about the negative consequences of rumination and whether they can be rescued by a mindfulness approach to life. Rumination is an internal cognitive state characterized by recursive thinking of self-distress and negative events focusing on the causes and consequences of distress rather than solutions. It cuts across diagnostic boundaries: It is associated with symptom severity and chronicity in both MDD and SZ. Mindfulness is associated with less distress from auditory hallucinations in SZ and fewer residual symptoms in MDD. It involves attending to present moment experiences and sensations and allowing emotions and thoughts to enter and leave consciousness without judgment, thereby avoiding a downward spiral into rumination. Compared to simple mind wandering, mindfulness recruits an attention network including parietal and prefrontal structures while mind wandering only recruits the default mode network. Long-COVID19. The newest population she is studying is the so-called ‘long-haulers’ following COVID19 infection. While the lungs are ground zero, COVID19 tears through organ systems from brain to blood vessels. Some who recover complain of ongoing problems, including lingering cognitive problems, depression, and anxiety. Dr. Ford has joined forces with both Lab Medicine and Radiology at SFVAMC to use psychological testing, neuroimaging methods, and markers in the blood signaling damage in the brain. A close look at these problems is timely and imperative if we are to understand the pathophysiology of “COVID brain” and prepare for down-stream problems.

福特博士是神经科学和精神病学领域的既定研究者，拥有神经科学和终身的博士学位 心理健康/精神病学的任命。她使用脑电图（EEG）和功能磁性 共振成像（fMRI），研究精神分裂症（SZ）和主要抑郁症的神经生物学 （MDD）。而现在，她正在用大脑成像研究的条件添加了Covid19的“长途运输器” 方法。 SZ。福特博士在SZ的工作重点是一种元素神经系统，该系统对自我的神经反应 与环境产生的刺激相比，产生的刺激。人们认为它反映了 涉及从电机到感觉区域的信号传导的效率副本/推论放电机制，准备 自我生成的感官事件的感觉区域。在所有动物物种中，这种机制无处不在， 她将这种机制转化为人类范式的工作发现了感官的根本赤字 精神病范围内的人的信息处理。有了NIH R01资金，她表现出缺陷 在这些机制中，与听觉幻觉和妄想有关。有了当前的NIH R03资金，她是 现在询问丘脑 - 甲状腺脉电流电路在该系统成功操作中的作用。 福特博士的两名VA受训者现在将这项工作扩展到新的精神病患者的样本，他们的第一名 学位亲戚，患有精神病的临床风险的年轻人以及未受到影响的对照参与者。他们是 查找小脑和PON之间的连通性与效果副本/推论的作用有关 放电机制。有了最近资助的NIH R03赠款，她询问脑电图是否受到评估 观念放缓对认知有上游影响，并有助于精神病的临床特征 精神分裂谱。由涉及VA精神科医生的机械临床试验（NIH R21）， VA放射科医生和UCSF心脏病专家，她正在询问生酮饮食是否可以恢复神经网络 SZ的稳定性，从而解决了认知定义和代谢综合征，与功能差有关 分别缩短了寿命。 MDD/SZ。大约4年前，她在她学习的临床人群中添加了MDD，并询问 反省的负面后果以及是否可以通过正念的生活方法来挽救它们。 反省是一种内部认知状态，其特征是递归思考自我仪式和负面事件 专注于困扰而不是解决方案的原因和后果。它跨越了诊断边界： 它与MDD和SZ的症状严重程度和慢性有关。正念与更少有关 SZ听觉幻觉的困扰，MDD中的残留症状较少。它涉及参加礼物 时刻的经历和感觉，让情绪和思想进入并留下意识 没有判断力，从而避免了螺旋式的反省。与简单的思维游荡相比 正念招募了一个注意网络，包括顶叶和前额叶结构，同时仅徘徊 招募默认模式网络。 Long-Covid19。她研究的最新人口是Covid19之后的所谓“长途旅行者” 感染。虽然肺部为零，但CoVID19通过器官系统从大脑到血管的撕裂。 一些人收回有关持续问题的抱怨的人，包括挥之不去的认知问题，抑郁和 焦虑。福特博士已在SFVAMC携带实验室医学和放射学，以使用心理 测试，神经影像学方法和大脑血液信号损害中的标记。仔细看看这些 如果我们要理解“ Covid Brain”的病理生理并为问题做准备，那么问题是及时的 下游问题。