Neural and cognitive consequences of COVID-19 survival.

COVID-19 生存对神经和认知的影响。

• 批准号: 10595562
• 负责人: Judith M Ford
• 金额: --
• 依托单位: VETERANS AFFAIRS MED CTR SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-10-01 至 2025-09-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10595562
• 关键词: Age; Aging; Amyloid beta-Protein; Anxiety; Attention; Auditory; Behavioral; Biological; Biological Assay; Biological Markers; Blood; Blood Vessels; Brain; Brain imaging; COVID-19; COVID-19 complications; COVID-19 impact; COVID-19 pandemic; COVID-19 survivors; Cells; Cessation of life; Clinic; Clinical; Cognition; Cognitive; Cognitive deficits; Collaborations; Data; Diabetes Mellitus; Electroencephalography; Event; Event-Related Potentials; Functional Magnetic Resonance Imaging; Functional disorder; HIV; Healthcare; Hemorrhage; Impaired cognition; Infection; Inflammation; Inflammatory; Internet; Laboratories; Laboratory Study; Light; Lung; Magnetic Resonance Imaging; Measures; Memory; Mental Depression; Methods; Myelin; Nerve Degeneration; Nervous System Trauma; Neural Cell Adhesion Molecule L1; Neurocognitive; Neurocognitive Deficit; Neurologic; Neuronal Dysfunction; Neurons; Neurophysiology - biologic function; Neuropsychology; Obesity; P300 Event-Related Potentials; Parents; Pathologic; Patient Recruitments; Peripheral; Persons; Pilot Projects; Plasma; Precipitation; Premature aging syndrome; Proteins; Psychological Tests; Reporting; Rest; SARS-CoV-2 infection; SARS-CoV-2 positive; San Francisco; Signal Transduction; Smoking; Techniques; Time; Translating; Veterans; Work; body system; cell injury; cognitive function; comorbidity; computerized; cytokine; experience; experimental study; extracellular vesicles; gray matter; high risk; long-term sequelae; magnetic resonance imaging/electroencephalography; neural; neurofilament; neuroimaging; neuroinflammation; neurophysiology; novel coronavirus; post SARS-CoV-2 infection; response; tau Proteins; white matter

The SARS-CoV-2 pandemic has been going on for over a year worldwide, with 115,000,000 confirmed cases and over 2,500,000 deaths (as of Mar 3, 2021). We are seeing people recover from the initial COVID19 infection with complaints of ongoing problems. An increasing number of people are complaining of cognitive deficits and depression/anxiety. Veterans are at a higher risk of COVID19 infection as well as suffering complications due to a number of co-morbidities. Veterans with neurocognitive complications may experience premature aging and neurodegeneration that could manifest as a huge burden for health care. We have brought together two laboratories studying neurocognitive impairment using an EEG, MRI, and behavioral approach as well as laboratory-based data. The Ford lab proposes to query neuropsychological function in Veterans using a computerized internet-based neuropsychological battery, EEG-based measures, functional MRI (connectivity) and structural MRI (gray and white matter volumes, myelin, micro-bleeds). The Pulliam lab has preliminary data to show a continued increase in plasma cytokines in COVID19 survivors. Plasma isolated neuronal enriched extracellular vesicles (nEVs) showed an increase in amyloid beta, neurofilament light and pT181- Tau, all proteins associated with neurodegeneration. The Overall Aim is to determine the extent of the cognitive, clinical, and neurological damage in people recovered from COVID19. The Specific Aims are to: 1) characterize neuropsychological function in COVID19 survivors, 2) assess EEG and MRI data in COVID19 survivors, 3) determine whether peripheral inflammation and markers of neuroinflammation, aging, and neurodegeneration persist in nEVs, and 4) explore relationships between neurodegenerative and inflammatory blood markers and EEG/MRI/NP measures while considering pre-existing co-morbidities and complications of COVID19.

SARS-CoV-2 大流行已在全球范围内持续一年多，感染人数已达 1.15 亿 确诊病例和死亡人数超过250万人（截至2021年3月3日）。我们看到人们康复了 从最初的新冠病毒感染到持续存在的问题的投诉。越来越多的 人们抱怨认知缺陷和抑郁/焦虑。退伍军人面临更高的风险 感染了新冠肺炎 (COVID19) 的患者，以及由于多种并发症而出现的并发症。 患有神经认知并发症的退伍军人可能会过早衰老 神经退行性疾病可能会给医疗保健带来巨大负担。 我们汇集了两个使用脑电图研究神经认知障碍的实验室， MRI、行为方法以及基于实验室的数据。福特实验室提出质疑 使用计算机化的基于互联网的神经心理学来研究退伍军人的神经心理功能 电池、基于脑电图的测量、功能性 MRI（连接性）和结构性 MRI（灰白色） 物质体积、髓磷脂、微出血）。普利亚姆实验室的初步数据显示， COVID19幸存者血浆细胞因子增加。血浆分离神经元富集 细胞外囊泡 (nEV) 显示β淀粉样蛋白、神经丝光和 pT181- 增加 Tau，所有与神经退行性变相关的蛋白质。总体目标是确定程度 新冠肺炎康复者的认知、临床和神经损伤。 具体目标是：1) 表征 COVID19 幸存者的神经心理功能，2) 评估 COVID19 幸存者的脑电图和 MRI 数据，3) 确定周围炎症是否存在 以及神经炎症、衰老和神经变性的标志物在 nEV 中持续存在，4) 探索 神经退行性和炎症血液标志物与 EEG/MRI/NP 之间的关系 采取措施的同时考虑到新冠肺炎 (COVID19) 先前存在的合并症和并发症。