Metabolic Consequences of Substance Use in Adolescent Girls

青春期女孩吸毒的代谢后果

基本信息

批准号：
7657016
负责人：
LORAH Denise DORN
金额：
$ 22.5万
依托单位：
CINCINNATI CHILDRENS HOSP MED CTR
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-05-15 至 2011-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7657016
关键词：
Accounting Acute-Phase Reaction Address Adolescence Adolescent Adolescent Medicine Adrenal Glands Adult Affect African American Age Alcohol consumption Alcohol or Other Drugs use Alcohols Anti-Inflammatory Agents Anti-inflammatory Anxiety Area Attention Behavioral Body mass index Bone Density Bone Development Bone Mineral Contents Calcium Cardiovascular Diseases Caucasians Caucasoid Race Characteristics Chronic Contraceptive Agents Data Data Analyses Development Discipline of Nursing Disease Early identification Elderly Employee Strikes Endocrinology Enrollment Ethnic Origin Female Adolescents Figs - dietary Fracture Freezing Frequencies Funding Future Gender Goals Gray unit of radiation dose Health Hormones Hydrocortisone Immune System Diseases Immune system Individual Differences Inflammatory Bowel Diseases Inflammatory Response Inflammatory Response Pathway Interleukin-10 Interleukin-4 Interleukin-6 Intervention Intramural Research Program Investigation Laboratories Lead Leptin Life Link Longevity Longitudinal Studies Malignant Neoplasms Malignant neoplasm of lung Measures Mediating Mediator of activation protein Menarche Mental Health Metabolic Methodology Minerals Modeling Morbidity - disease rate Osteoporosis Osteoporosis prevention Outcome Parents Pathway interactions Pediatrics Physical activity Pituitary Gland Pituitary-Adrenal System Prevention Prevention strategy Preventive Intervention Process Psychology Puberty Public Health Race Reporting Research Risk Risk Behaviors Role Sampling Science Serum Smoke Smoker Smoking Smoking Status Social Class Social Problems Specimen Staging Stress System Teenagers Testing Theoretical model Time Tobacco smoking United States National Institutes of Health Visit Woman Women&apos s Health alcohol behavior alcohol consequences base biobehavior bone bone health bone mass boys critical period cytokine depression depressive symptoms experience girls immune function innovation lifestyle factors men mortality new technology novel osteoporosis with pathological fracture psychologic public health relevance reproductive response smoking cessation statistics

项目摘要

DESCRIPTION (provided by applicant): Osteoporosis is a major public health problem affecting over 10 million adults, primarily women. A key contributor to osteoporosis prevention is optimizing accrual of peak bone mass. Adolescence is a dynamic period for bone mass development as nearly 50% of mass is accrued primarily around puberty. Smoking, alcohol, & depression can negatively influence bone mass. Experimentation with substances begins and escalates in adolescence and in those more vulnerable, detrimental effects on health can occur across the lifespan. Depression also increases. There are differential rates and/or morbidity-mortality consequences by gender for substance use and depression with girls being more affected than boys. Compared to men, adult women have more difficulty in smoking cessation, are more likely to experience depression in cessation, and are more sensitive to negative consequences of alcohol. Further, depression is also linked with osteoporosis or low bone mass more so in women. No studies in adolescence have examined effects of substance use and depression on metabolic consequences, such as bone health. The R21 proposes to examine such issues in a biobehavioral conceptual model. Secondary analysis will be conducted in 264 girls (11-17 years) enrolled in a cross-sequential study for 3 annual visits (Dorn; PI; R01 DA16402). The sample reflects diversity in race/ethnicity (African-American 31.1%; Caucasian 63.3%) and social class. Retention is >90%. We include examination of alcohol use and analysis of frozen samples for cytokine activity and other hormones. Unique aims were added to examine the stress system and systemic inflammatory responses (cytokine activity) as potential mechanisms explaining the relationship of depression and substance use with bone health (bone mineral content). Aims are: (1) To examine characteristics of individual differences in developmental trajectories of bone health across 3 years by alcohol status. (2) To examine contextual effects of smoking and alcohol on the mediating pathway of stress system (HPA axis) activity on the relationship between symptoms of depression/anxiety and individual differences in developmental trajectories of bone health across 3 years. (3) To examine contextual effects of smoking and alcohol on the mediating pathway of the systemic inflammatory response (serum cytokine activity) on the relationship between depression/anxiety and individual differences in developmental trajectories of bone health across 3 years. Examining the impact of these factors has import for future intervention and prevention strategies in adolescence. The pathway to osteoporosis is multifactorial and begins early in life. Substance use and depression in adolescence may have long-term consequences for bone health (i.e. > risk of osteoporotic fracture). PUBLIC HEALTH RELEVANCE: Osteoporosis is a major public health problem. The pathway to osteoporosis is multifactorial and begins early in life. Puberty is a dynamic period of development for optimal bone accrual and a critical time where substance use and mental health problems emerge. We propose to examine the combined impact of timing of puberty, substance use, and depression/anxiety on bone health in adolescent girls. Focusing on the potential mechanism involved in this relationship including stress system hormones and cytokines, may enhance intervention and prevention efforts for poor bone health.

描述（由申请人提供）：骨质疏松症是影响超过 1000 万成年人（主要是女性）的主要公共卫生问题。预防骨质疏松症的一个关键因素是优化峰值骨量的累积。青春期是骨量发育的动态时期，近 50% 的骨量主要是在青春期左右累积的。吸烟、饮酒和抑郁会对骨量产生负面影响。对物质的实验在青春期开始并逐步升级，对于那些更脆弱的人来说，对健康的有害影响可能会在整个生命周期中发生。抑郁症也会增加。药物使用和抑郁症的发病率和/或发病率-死亡率后果因性别而异，女孩比男孩受到的影响更大。与男性相比，成年女性戒烟更困难，戒烟时更容易出现抑郁症，对酒精的负面后果更敏感。此外，抑郁症还与骨质疏松症或低骨量有关，在女性中尤其如此。尚无青春期研究探讨物质使用和抑郁对代谢后果（例如骨骼健康）的影响。 R21 建议在生物行为概念模型中研究此类问题。将对参加每年 3 次访问的交叉序列研究的 264 名女孩（11-17 岁）进行二次分析（Dorn；PI；R01 DA16402）。样本反映了种族/民族（非裔美国人 31.1%；白种人 63.3%）和社会阶层的多样性。保留率 >90%。我们包括酒精使用检查以及冷冻样本的细胞因子活性和其他激素分析。添加了独特的目标来检查压力系统和全身炎症反应（细胞因子活性），作为解释抑郁和物质使用与骨骼健康（骨矿物质含量）关系的潜在机制。目的是： (1) 通过酒精状况检查 3 年内骨骼健康发育轨迹的个体差异特征。 (2) 考察吸烟和饮酒对压力系统（HPA 轴）活动的介导途径对抑郁/焦虑症状与 3 年骨骼健康发育轨迹个体差异之间关系的影响。 (3) 考察吸烟和饮酒对全身炎症反应（血清细胞因子活性）介导途径的背景影响，以及抑郁/焦虑与3年骨骼健康发育轨迹个体差异之间的关系。检查这些因素的影响对于未来的青春期干预和预防策略很重要。骨质疏松症的发病途径是多因素的，并且从生命早期就开始了。青春期的药物使用和抑郁可能会对骨骼健康产生长期影响（即 > 骨质疏松性骨折的风险）。公共卫生相关性：骨质疏松症是一个主要的公共卫生问题。骨质疏松症的发病途径是多因素的，并且从生命早期就开始了。青春期是最佳骨质增生的动态发育时期，也是出现药物滥用和心理健康问题的关键时期。我们建议研究青春期时间、药物滥用和抑郁/焦虑对青春期女孩骨骼健康的综合影响。关注这种关系中涉及的潜在机制，包括应激系统激素和细胞因子，可能会加强对骨骼健康不良的干预和预防工作。