Metabolic Consequences of Substance Use in Adolescent Girls

青春期女孩吸毒的代谢后果

基本信息

批准号：
7657016
负责人：
LORAH Denise DORN
金额：
$ 22.5万
依托单位：
CINCINNATI CHILDRENS HOSP MED CTR
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-05-15 至 2011-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7657016
关键词：
Accounting Acute-Phase Reaction Address Adolescence Adolescent Adolescent Medicine Adrenal Glands Adult Affect African American Age Alcohol consumption Alcohol or Other Drugs use Alcohols Anti-Inflammatory Agents Anti-inflammatory Anxiety Area Attention Behavioral Body mass index Bone Density Bone Development Bone Mineral Contents Calcium Cardiovascular Diseases Caucasians Caucasoid Race Characteristics Chronic Contraceptive Agents Data Data Analyses Development Discipline of Nursing Disease Early identification Elderly Employee Strikes Endocrinology Enrollment Ethnic Origin Female Adolescents Figs - dietary Fracture Freezing Frequencies Funding Future Gender Goals Gray unit of radiation dose Health Hormones Hydrocortisone Immune System Diseases Immune system Individual Differences Inflammatory Bowel Diseases Inflammatory Response Inflammatory Response Pathway Interleukin-10 Interleukin-4 Interleukin-6 Intervention Intramural Research Program Investigation Laboratories Lead Leptin Life Link Longevity Longitudinal Studies Malignant Neoplasms Malignant neoplasm of lung Measures Mediating Mediator of activation protein Menarche Mental Health Metabolic Methodology Minerals Modeling Morbidity - disease rate Osteoporosis Osteoporosis prevention Outcome Parents Pathway interactions Pediatrics Physical activity Pituitary Gland Pituitary-Adrenal System Prevention Prevention strategy Preventive Intervention Process Psychology Puberty Public Health Race Reporting Research Risk Risk Behaviors Role Sampling Science Serum Smoke Smoker Smoking Smoking Status Social Class Social Problems Specimen Staging Stress System Teenagers Testing Theoretical model Time Tobacco smoking United States National Institutes of Health Visit Woman Women&apos s Health alcohol behavior alcohol consequences base biobehavior bone bone health bone mass boys critical period cytokine depression depressive symptoms experience girls immune function innovation lifestyle factors men mortality new technology novel osteoporosis with pathological fracture psychologic public health relevance reproductive response smoking cessation statistics

项目摘要

DESCRIPTION (provided by applicant): Osteoporosis is a major public health problem affecting over 10 million adults, primarily women. A key contributor to osteoporosis prevention is optimizing accrual of peak bone mass. Adolescence is a dynamic period for bone mass development as nearly 50% of mass is accrued primarily around puberty. Smoking, alcohol, & depression can negatively influence bone mass. Experimentation with substances begins and escalates in adolescence and in those more vulnerable, detrimental effects on health can occur across the lifespan. Depression also increases. There are differential rates and/or morbidity-mortality consequences by gender for substance use and depression with girls being more affected than boys. Compared to men, adult women have more difficulty in smoking cessation, are more likely to experience depression in cessation, and are more sensitive to negative consequences of alcohol. Further, depression is also linked with osteoporosis or low bone mass more so in women. No studies in adolescence have examined effects of substance use and depression on metabolic consequences, such as bone health. The R21 proposes to examine such issues in a biobehavioral conceptual model. Secondary analysis will be conducted in 264 girls (11-17 years) enrolled in a cross-sequential study for 3 annual visits (Dorn; PI; R01 DA16402). The sample reflects diversity in race/ethnicity (African-American 31.1%; Caucasian 63.3%) and social class. Retention is >90%. We include examination of alcohol use and analysis of frozen samples for cytokine activity and other hormones. Unique aims were added to examine the stress system and systemic inflammatory responses (cytokine activity) as potential mechanisms explaining the relationship of depression and substance use with bone health (bone mineral content). Aims are: (1) To examine characteristics of individual differences in developmental trajectories of bone health across 3 years by alcohol status. (2) To examine contextual effects of smoking and alcohol on the mediating pathway of stress system (HPA axis) activity on the relationship between symptoms of depression/anxiety and individual differences in developmental trajectories of bone health across 3 years. (3) To examine contextual effects of smoking and alcohol on the mediating pathway of the systemic inflammatory response (serum cytokine activity) on the relationship between depression/anxiety and individual differences in developmental trajectories of bone health across 3 years. Examining the impact of these factors has import for future intervention and prevention strategies in adolescence. The pathway to osteoporosis is multifactorial and begins early in life. Substance use and depression in adolescence may have long-term consequences for bone health (i.e. > risk of osteoporotic fracture). PUBLIC HEALTH RELEVANCE: Osteoporosis is a major public health problem. The pathway to osteoporosis is multifactorial and begins early in life. Puberty is a dynamic period of development for optimal bone accrual and a critical time where substance use and mental health problems emerge. We propose to examine the combined impact of timing of puberty, substance use, and depression/anxiety on bone health in adolescent girls. Focusing on the potential mechanism involved in this relationship including stress system hormones and cytokines, may enhance intervention and prevention efforts for poor bone health.

描述（由申请人提供）：骨质疏松症是影响超过1000万成年人（主要是妇女）的主要公共卫生问题。预防骨质疏松症的关键因素是优化峰值骨骼质量的应计。青春期是骨质量发育的动态时期，因为近50％的质量主要是在青春期围绕的。吸烟，酒精和抑郁会对骨骼产生负面影响。在青春期开始并升级物质的实验，并且在那些更脆弱的情况下，整个生命周期可能会对健康产生不利影响。抑郁症也会增加。性别对药物使用和抑郁症的性别产生差异和/或发病率，女孩比男孩受到更大的影响。与男性相比，成年女性在戒烟方面有更多的困难，更有可能在戒烟方面遭受抑郁症，并且对酒精的负面后果更敏感。此外，抑郁症还与骨质疏松症或低骨量有关。青春期没有研究对药物使用和抑郁症对代谢后果（例如骨骼健康）的影响。 R21建议在生物行为概念模型中检查此类问题。次级分析将在参加3个年度访问的跨序列研究（DORN; PI; R01 DA16402）的264名女孩（11-17岁）中进行。该样本反映了种族/种族的多样性（非裔美国人31.1％；高加索人63.3％）和社会阶层。保留率> 90％。我们包括对酒精使用的检查以及对细胞因子活性和其他激素的冷冻样品的分析。添加了独特的目标来检查压力系统和全身性炎症反应（细胞因子活性），作为解释抑郁症和药物使用与骨骼健康的关系的潜在机制（骨矿物质含量）。目的是：（1）检验3年来通过酒精状态来检查骨骼健康发展轨迹的个体差异的特征。（2）检查吸烟和酒精对抑郁症/焦虑症症状与骨骼健康发展轨迹的症状之间的关系的介导途径（HPA轴）活性对骨骼健康症状之间的关系的上下文影响。（3）检查吸烟和酒精对全身性炎症反应（血清细胞因子活性）的介导途径的上下文影响对抑郁症/焦虑与个体差异之间的关系在3年中的骨骼健康发展轨迹中的关系。检查这些因素的影响有进口对未来的干预和青春期预防策略的进口。通往骨质疏松症的途径是多因素的，并从生命的早期开始。青春期药物使用和抑郁症可能会对骨骼健康产生长期后果（即>骨质疏松性骨折的风险）。公共卫生相关性：骨质疏松症是一个主要的公共卫生问题。通往骨质疏松症的途径是多因素的，并从生命的早期开始。青春期是最佳骨骼应计的动态发展时期，是出现物质使用和精神健康问题的关键时期。我们建议检查青春期女孩的青春期，药物使用和抑郁/焦虑对青少年女孩骨骼健康的综合影响。专注于这种关系中涉及的潜在机制，包括压力系统激素和细胞因子，可能会增强骨骼健康不良的干预和预防工作。