GENETICS OF BONE LOSS AT THE HIP IN WOMEN

女性臀部骨质流失的遗传学

• 批准号: 7379056
• 负责人: MUNRO PEACOCK
• 金额: $ 3.23万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379056
• 关键词: GENETICS; BONE; LOSS; HIP; WOMEN

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Heritability of bone mass at the hip is high, but heritability of bone loss at the hip has not been studied. Heritability of bone strength has been measured in 760 pairs of sisters, and a 10cM genome screen has identified several chromosomal loci influencing strength. The hypotheses that will be tested is that the rate of bone loss at the hip in women is genetically determined. This will be achieved by remeasuring hip bone mass in 500 pairs of sisters that had participated in the GCRC Protocol 578 a minimum of 5 years ago. Using the Lunar DPX-L dual X-ray absorptiometry (DXA) the following sites will be measured: the right femoral neck, trochanter and wards, lumbar vertebrae L2 to L4 and total body. Radiographs of the lower pelvis with upper femura in 15 degree internal rotation will be taken on standard X-ray equipment. All structural measurements will be made on the same hip using a digital caliper. Volumetric Quantitative Computed Tomograph (CT) will be performed according to an established protocol. Fasting blood and urine will be collected for measurement of calcium regulating hormones and bone turnover markers. Anthropometrics will be collected on dedicated instruments, total body lean and fat are measured by DXA. Questionnaires will be administered which include personal, family and medical history, gynecological history, medication history, smoking, physical activity and diet. All questionnaires have been verified and have been in use over the last five years in the current sister study.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。髋部骨量的遗传力较高，但髋部骨质流失的遗传力尚未研究。已经测量了 760 对姐妹的骨强度遗传力，并且 10cM 基因组筛选已确定了几个影响强度的染色体位点。将要检验的假设是，女性臀部骨质流失的速度是由基因决定的。这将通过重新测量至少 5 年前参与 GCRC 协议 578 的 500 对姐妹的髋骨质量来实现。使用 Lunar DPX-L 双 X 射线吸收仪 (DXA) 将测量以下部位：右股骨颈、转子和病房、腰椎 L2 至 L4 和全身。将在标准 X 射线设备上拍摄下骨盆和上股骨 15 度内旋的射线照片。所有结构测量都将使用数字卡尺在同一个臀部进行。将根据既定方案进行体积定量计算机断层扫描 (CT)。将收集空腹血液和尿液以测量钙调节激素和骨转换标志物。人体测量数据将在专用仪器上收集，全身瘦肉和脂肪由 DXA 测量。将进行调查问卷，其中包括个人、家族和病史、妇科病史、用药史、吸烟、体力活动和饮食。所有问卷都经过验证，并且在过去五年中一直在当前的姊妹研究中使用。