GENETICS OF BONE STRENGTH IN MEN

男性骨骼强度的遗传学

• 批准号: 7379055
• 负责人: MUNRO PEACOCK
• 金额: $ 5.45万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379055
• 关键词: GENETICS; BONE; STRENGTH; MEN

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Age-related osteoporotic fracture, particularly hip fracture, is a major health problem in the United States and worldwide. Age-related decrease in bone strength is a major risk factor for osteoporotic fracture. Components of bone strength are highly heritable, and in our studies using premenopausal sister pairs, we have detected linkage to several measures of both bone mass and bone structure. Heritability studies on measure of bone strength in men are very limited. Futhermore, studies in mice suggest that sex specific genes may underlie differences in bone strength between men and women. The hypothesis that will be tested in this study is that in men bone mass, bone structure , bone quality and bone turnover have components that are genetically determined and are similar in magnitude to those we have established in women. However, while many loci will be the same in both sexes, certain loci will be sex specific. The skeletal sites that are being measured by dual X-ray absorptiometry are right femoral neck, trochanter and wards, lumbar vertebrae L2 to L4 and total body. Radiographs of the lower pelvis with upper femura in 15 degrees internal rotation are taken on standard X-ray equipment. All structural measurements are made on the right hip (the same measured by DXA) using a digital caliper. Fasting blood and urine will be collected for measurement of calcium regulating hormones and biochemical markers of bone turnover. Anthropometrics are measured on dedicated instruments; total body lean and fat are measured by DXA. The questionnaires include personal, family and medical history, medication history, smoking, physical activity and dietary questionnaires. All questionnaires have been verified and have been use over the last five years in GCRC Protocol 578.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。与年龄相关的骨质疏松性骨折，特别是髋部骨折，是美国和全世界的一个主要健康问题。与年龄相关的骨强度下降是骨质疏松性骨折的主要危险因素。骨强度的组成部分具有高度遗传性，在我们使用绝经前姐妹对的研究中，我们发现了与骨量和骨结构的多种测量值之间的联系。关于男性骨强度测量的遗传性研究非常有限。此外，对小鼠的研究表明，性别特异性基因可能是男性和女性骨强度差异的基础。本研究将检验的假设是，男性的骨量、骨结构、骨质量和骨转换具有由基因决定的成分，并且其数量与我们在女性中建立的成分相似。然而，虽然许多基因座在两性中是相同的，但某些基因座将是性别特异性的。双X射线骨密度仪测量的骨骼部位是右股骨颈、转子和病房、腰椎L2至L4和全身。在标准 X 射线设备上拍摄下骨盆和上股骨 15 度内旋的射线照片。所有结构测量均使用数字卡尺在右髋部进行（与 DXA 测量的结果相同）。将收集空腹血液和尿液以测量钙调节激素和骨转换的生化标志物。人体测量是在专用仪器上测量的；全身瘦肉和脂肪通过 DXA 测量。调查问卷包括个人、家族和病史、用药史、吸烟、体力活动和饮食调查问卷。所有调查问卷均经过验证，并在过去五年中在 GCRC 协议 578 中使用。